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Ch. 44
Antiinflammatory and Antigout
| Question | Answer |
|---|---|
| What properties do NSAIDs have | analgesic, antipyretic, antiinflammatory, antirheumatic |
| What is released in response to injury to begin response | arachidonic acid which causes pain, headache, fever, inflammation |
| what is MOA of analgesia | block prostaglandin pathway and lipoxygenase pathway, limit inflammation |
| what is MOA of antipyretic | inhibit prostaglandin E2 in brain that controls temp |
| what are chemical categories of NSAIDs | salicylates acetic acid derivatives cyclooxygenase-2 (COX-2)inhibitors enolic acid derivatives propionic acid derivatives |
| what do salicylates also have and name one | antiplatelet activity aspirin, diflunisal(Dolobid) |
| Name some acetic acids | indocin toradol voltaren clinoril tolectin lodine ponstel |
| Name a Cox-2 inhibitor | Celebrex- arthritis, dysmenorrhea(painful period) |
| Name Enolic acid derivatives | piroxicam(Feldene) meloxican (Mobic) namumetone(Relafen) |
| Name some propionic acids | Nalfon, Ansaid, Motrin, Advil, Naprosyn, Aleve, Daypro |
| What is Gout | inappropriate uric acid metabolism; underexcretion/overproduction uric acid crystals are deposited in tissues, joint give pain |
| antigout drugs "Cold compress" | allpurinol(Zyloprim)-prevent uric acid production colchicine-reduce inflammation probenecid(Benemid), sulfinpyrazone(Anturane)- incr excretion of uric acid in urine |
| NSAID adverse effects what drug helps with effects | dyspepsia- indigestion, GI bleeding, mucosal lesions misoprostol(Cytotec)- reduce effects, induce labor |
| what is the best kidney fx test | creatinine clearance test- how well creatine is cleared from your blood to go to urine |
| Aspirin toxicity | tinnitus, ototoxicity, hyperventilation, CNS effects, levels above 40-60mg/dl, metabolic acidosis, resp. alkalosis |
| NSAIDs interact with | anticoagulants, aspirin, corticosteroids, ulcerogenic(ulcer forming)drugs, protein bound drugs, diuretics, ACE inhibitors |
| What is to be noted about antirheumatoid drugs | slow onset of action, 3-6 mos, more toxic effects, known as DMARDs(disease-modifying antifreumatic drugs) |
| Name some DMARDs | auranofin, aurothioglucose, gold sodium thiomalate (weekly injection), leflunomide |
| what herbal products act as NSAIDs | Glucosamine & Chondroitin enhance warfarin, incr insulin resistance |
| why do you not give salicylates to children and teens | Reye's syndrome, encephalopothy, liver shutdown |
Created by:
palmerag
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