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Ziance1.7Cholinergic

DrugMOAIndicationADRContraindicationsNotesDrug interactions
Pilocarpine(Isopto-Carpine Salagen) Muscarinic receptor agonist, cross BBB Glaucoma: open angle and closed angle;Reverse drug induced mydriasis;Miotic for eye surgery;Xerostomia associated with Sjogren’s syndrome Mushroom poisoning symptoms,Confusion, agitation (cevimeline and pilocarpine are 3° amines) • Decreased night vision • Hypersalivation ● Diaphoresis • Bradycardia, cardiac arrhythmia • Hypotension Uncontrolled asthma Antimuscaricins
Physostigmine AChE inhibitor reversible crosses BBB
organophosphates, inse AChE inhibitor irreversible crosses BBB ANS-miosis blurred vision sweating,salivation,bronchospasm bronchial secretion,diarrhea arrhythmiahypoten. CNS-agitation confusion seizures coma Death respiratory paralysis cardiac arrest DFP, Tabun, Malathion, Parathion
Varenicline Chantix Varenicline (Chantix) ▪ agonist of presynaptic α4β2 receptors increases DA release in N. Accumbens. ▪ antagonist prevents binding of nicotine presynaptic α4β2 nAChR receptors. ● prevents stimulation or the reward pathway. Smoking cessation aid Nausea ● Sleep disturbance, suicide, psychosis Nicotine receptor agonist and antagonist
Nicotine Nicorette Commit • Peripheral ▫stimulate Nn receptors of ANS ganglia plus adrenal medulla • CNS ▫ agonist of presynaptic α4 β2 nicotinic receptors (Nα4 β2) in N. Accumbens Smoking cessation Nausea Sleep disturbances
Bethanechol(Urecholine) Muscarinic receptor agonist dont cross BBB Postoperative ileus and/or urinary retention Mushroom poisoning symptoms,Confusion, agitation (cevimeline and pilocarpine are 3° amines) • Decreased night vision • Hypersalivation ● Diaphoresis • Bradycardia, cardiac arrhythmia • Hypotension Uncontrolled asthma selective agonist of muscarinic receptors Antimuscaricins
Carbachol(Isopto-Carbachol) Muscarinic receptor agonist Dont cross BBB Glaucoma: open angle and closed angle Mushroom poisoning symptoms,Confusion, agitation (cevimeline and pilocarpine are 3° amines) • Decreased night vision • Hypersalivation ● Diaphoresis • Bradycardia, cardiac arrhythmia • Hypotension Uncontrolled asthma a nonselective agonist of muscarinic and nictotinic receptors Antimuscaricins
Cevimeline (Evoxac) Muscarinic receptor agonist, cross BBB Xerostomia associated with Sjogren’s syndrome Mushroom poisoning symptoms,Confusion, agitation (cevimeline and pilocarpine are 3° amines) • Decreased night vision • Hypersalivation ● Diaphoresis • Bradycardia, cardiac arrhythmia • Hypotension Uncontrolled asthma Antimuscaricins
Edrophonium(Tensilon) Neostigmine(Prostigmin) AChE inhibitor reversibledoes not cross BBB involving skeletal muscle;Myasthenia gravis increase stimulation of available functional Nm receptors of NMJ
Created by: 727138192
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