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Random Pharm Exam4
Pharm 1 - Fall 2011
Question | Answer |
---|---|
Volume depletion involving third-space sequestration? | -Fracture -Acute Pancreatitis -Crush injury -Intest obstrux |
Muscle wkness can be caused by? | Hypo or Hyperkalemia |
Polyuria and Polydipsia can be caused by? | Hyperglycemia or severe hypokalemia |
Lethargy, confusion, seizures, and coma can be d/t? | HypoNa+, HyperNa+, Hyperglycemia |
Rate of repletion for severe volume depletion or hypovolemic shock? | 1-2L NS as quick as poss! (to restore tiss perfusion) -Then: Fluid repletion is continued at rapid rate until clinical signs normalize |
Rate of repletion for mild to mod hypovolemia? | 50-100mL/hr in excess of continued losses |
What is the estimated insensible loss per hr? | 30-50mL/hr |
Overly rapid correction of which substance may lead to irreversible neuro damage? | Plasma Na+ Concentration |
If pt on IV fluids for long pd...remember to monitor? | Ca, Cl, P, Mg (and vitamins and proteins) |
Hypotonic soln may cause what in the very ill or when used for prolonged pd of time? | Hyponatremia |
Replacement of insensible losses should be with? | Hypotonic Saline or 5% dextrose |
1L of IV fluid weighs? | 1 kg |
Excess mg can cause? | Diarrhea |
Excess Ca, Al can cause? | Constipation |
Drug interax w/ Cimetidine? | (Is an H2RA) -CYP450 Inhib (^Cp of anticoags, theophylline, phenytoin) |
What is a ?able RF for NSAID-induced PUD? | Cig smoking |
Does Ibuprofen or Naproxen have a higher GI toxicity? | Naproxen |
How to prevent NSAID-induced ulcers in those at high risk? | Px w/ Misoprostol or PPI (works as well as misoprotol, but better tolerated) |
Std doses of a PPI and a non-selective NSAID are just as effective as a what in reducing the risk of NSAID-induced ulcers and upper GI complications? | Cox-2 inhibs |
What do H2RAs prevent and what don't they (in NSAID-induced ulcers)? | Prevent duodenal ulcers, NOT gastric ulcers |
Sucralfate and Antacids are not effective for prevention of? | NSAID-induced ulcers |
How long does it usually take for an ulcer to heal? | ~4wks (gastric ulcers take longer to heal vs duodenal ulcers) |
If have an ulcer and NSAID must be continued,what is the tx of choice? | PPI |
H2RA and PPI provide symptomatic relief at what point after starting them for an ulcer? | ~1 wk |
Relief of ulcer pain DOES NOT directly correlate with? | Ulcer healing |
Pt presents w/ ulcer-like sxs...what are alarm sxs? | Bleeding, wt loss, anemia |
Drugs that decrs LES tone? | CCBs, Estrogens, Theophylline, Nitrates, Narcotics, Nicotine, Progesterone, Ethanol, Caffeine |
Meals rich in what are recommended for those with GERD that can augment the LES tone? | Protein-rich meals |
Water and electrolyte losses during acute diarrhea are what kind of losses? | Isotonic losses (so should be replaced as "isotonic") |
Types of diarrhea? | Secretory, osmotic, exudative, Altered intest transit |
If someone is infected w/ E.coli, why should you not kill the pathogen? | Killing it will cause it to release its toxins and cause even worse problems |
Why shouldn't you eat solids when have diarrhea? | If have a pathogen, don't want to keep it in there |
MC bacterial pathogens of AOM from MC to LC? | S.pneumo>H.flu>M.cat |
35% of S.pneumo of AOM is resistant d/t what? | Altered PBP sites |
Resis S.pneumo is espec prev in who? (for AOM) | Kids <2yo, in daycare, receivd abx therapy in last 3 mo's |
H.flu of AOM may present concominantly with? | Conjunctivitis |
A dx of AOM requirs? | 1. Hx of acute onset of sx/signs 2. MEE 3. Signs/sx of midd ear inflamm |