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Diagnostic Lab resul
| Question | Answer |
|---|---|
| What is the purpose of laboratory tests? | Results guide diagnosis, prognosis, and treatment. |
| How do you create a reference interval? | Test samples from at least 30-40 healthy animals. Analyze results to see if normally distributed. A RI includes only 95% of results. 5% of healthy animals will have a result that falls outside RI. |
| Does using a more diverse population tested make the RI wider or narrower? | Wider. |
| Should RI be transferred between labs? | NO |
| What is analytical specificity? | The ability of a test to identify patients that do not have a particular disease. The percentage of TN results. It is a confirmatory test. |
| A test with high specificity will have a relatively low percentage of what kind of results? | False Positives |
| What is analytical sensitivity? | The ability of a test to identify diseased subjects. The percentage of TP results. |
| A sensitive test will pick up most animals that do or do not have the disease? | DO have the disease. It will have a low percentage of false negative results. It is a screening test. |
| What is accuracy? | How close to the true answer the new test is giving you. Can compare new results to an old test that has been proven accurate. |
| What is precision? | Reproducibility. IF an analyte is measured repeatedly in the lab, how close will the results be to one another? |
| What is the importance of a diagnostic cut-off level | It is often advantageous to set the cut-off level to get the best combination of sensitivity vs. specificity. If you put cut off too far, might give you false results. |
| What is the positive predictive value? | The percentage of patients with a positive or abnormal test result that are actually diseased. |
| The PPV is higher in a population with a ___ incidence of the disease in question? | HIGH |
| Does using multiple tests increase or decrease the PPV? | Increases |
| What is the negative predictive value? | The percentage of patients with a negative or normal test result that are actually free of disease |
| Doing multiple tests in parallel increases or decreases the NPV? | Increases |
| What are some sources of inaccuracy in test results? | Patient factors, Sample handling factors, sample quality factors, laboratory errors, reporting errors |
| What is the importance of good quality control procedures? | Should be used to detect and minimize laboratory errors |
Created by:
bazkb4
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