Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

318: Ch 73 Gout

Drugs for Gout

QuestionAnswer
what are 2 characteristic traits of Gout? Gout is a recurrent inflammatory disorder characterized by HYPERURICEMIA and episodes of SEVERE JOINT PAIN
what are 2 potential causes for Gout? (1) Excessive production of uric acid. (2) Impaired excretion of uric acid (kidney dysfunction)
Name 4 s/s of gout. pain, swelling, redness, warmth (HOT)
what lab values do you look at to distinguish Gout from cellulitis? Uric acid vs WBC
When do you use short term/long term gout drugs? LONG TERM >3 attacks/year. SHORT TERM <3 attacks per year
What 3 NSAIDs are used for Gout? Indomethacin, Naproxen, Voltaren
When glucocorticoids are used for gout, what are the administration routes? PO [Prednisone] or IM
Are glucocorticoids used for acute gouty attacks in gout or long term? Glucocorticoids are used for acute gouty attacks
who should NOT take glucocorticoids? Diabetics (hyperglycemia)
What is the name of the drug that is SPECIFIC for gout? Colchicine
What is special about Colchicine? Colchicine is an anti-inflammatory agent that is ONLY SPECIFIC for GOUT!
is Colchicine used for acute gouty attacks or as prophylaxis? BOTH!!! large doses relieve gouty attacks. lower doses can decrease frequency/intensity of acute flair ups.
What are the adverse effects of Colchicine? GI toxicity (principle adverse effect) n/v/d/abdominal pain. if GI symptoms develop, DC the drug IMMEDIATELY! [risks include bone marrow suppression, renal failure, hepatic necrosis, seizures and death]
By what route is Colchicine administered? IV or PO (readily absorbed PO)
Colchicine and pregnancy? probably not. [Oral = Category C. IV = Category D]
which drugs are used for acute gouty attacks? NSAIDs(first line), Glucocorticoids, colchicine
What is the uric acid level in a gout pt? men/women men >7. women >6
what drugs are used for prophylactic treatment of gout? Allopurinol [Zyloprim], Febuxostat [Uloric]
What is the drug of choice for chronic tophaceous gout? Allopurinol [Zyloprim]
What is the mechanism of action for Allopurinol? Inhibits uric acid formation. Reverses hyperuricemia (Decreases the risk for nephropathy from deposition of urate chrystals in the kidneys)
What is Allopurinol used for? Prophylactic treatment for gout
What are the side effects of Allopurinol? Hypersensitivity syndrome (rash, fever, eosinophillia, dysfunction of liver/kidneys, n/v/d, Neuro effects (drowsiness, headache, metallic taste) PROLONG use -> Cataracts
route of administration for ALlopurinol: oral
drug interactions for allopurinol Allopurinol inhibits hepatic drug-metabolizing enzymes and can DELAY THE INACTIVATION OF OTHER DRUGS (PARTICULAR CONCERN FOR WARFARIN)
what is the mechanism of action for Febuxostat [Uloric] lowers urate levels by inhibiting XO
after starting Febuxostat [Uloric], what should patients be on? Patients should receive prophylactic NSAIDs or colchicine for up to 6 months after starting this treatment.
What are the adverse effects of Febuxostat []Uloric] Liver function abnormalities, n, arthralgia, rash
administration frequency of Febuxostat 1x/day
Created by: 1398660434
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards