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Chapter 28-31

Cholineserase Inhibitors

QuestionAnswer
donepezil (Aricept) dementia due to AD, S/E headache, nausea, diarrhea, insomnia, muscle cramps
memantine (Namenda) moderate to severe AD, S/E dizziness,headache, confusion
rivastigmine (Exelon) demntia of AD, Parkinson's Disease, S/E nausea, vomiting, diarrhea, dyspepsia, anorexia, insomnia, fatigue, dizziness, headache
tacrine (Cognex) mild to moderate AD dementia, S/E nauea, vomiting, diarrhea, dizziness, headache, eleveated liver function
carbidopa (Lodosyn) Used with levodopa in the treatment of Parkinson’s disease, S/E None by its self; adverse reactions are those of levodopa
carbidopa/levodopa (Sinemet, Sinemet CR, Parcopa, Carbilev) Parkinson’s disease, S/E Anorexia, nausea, vomiting, abdominal pain, dysphagia, dry mouth, mental changes, headache, dizziness, increased hand tremor, choreiform or dystonic movements
benztropine (Cogentin) Parkinson’s disease, drug-induced EPS, S/E Dry mouth, blurred vision, dizziness, nausea, nervousness, skin rash, urinary retention, dysuria, tachycardia, muscle weakness, disorientation, confusion
entacapone (Comtan) As adjunct to levodopa/carbidopa in Parkinson’s disease, S/E Dyskinesia, hyperkinesia, nausea, diarrhea, urine discoloration
pramipexole (Mirapex) Parkinson’s disease, S/E Dizziness, somnolence, insomnia, hallucinations, confusion, nausea, dyspepsia, syncope
phenytoin (Dilantin) Tonic-clonic seizures, status epilepticus, prophylactic seizure prevention, S/E Ataxia, CNS depression, headache, hypotension, nystagmus, mental confusion, slurred speech, dizziness, drowsiness, nausea, vomiting, gingival hyperplasia, rash
valproic acid (Depakote, Depakene) Epilepsy, migraine headache, mania, S/E , somnolence, dizziness, tremor, nausea, vomiting, diplopia
diazepam (Valium, Diasta) Status epilepticus, seizure disorders (all forms), anxiety disorders, alcohol withdrawal, S/E Drowsiness, depression, ataxia, anorexia, diarrhea, constipation, dry mouth, palpitations, visual disturbances, rash
lorazepam (Ativan) Status epilepticus, preanesthetic, S/E Drowsiness, depression, ataxia, anorexia, diarrhea, constipation, dry mouth, palpitations, visual disturbances, rash
phenobarbital (Luminal) Status epilepticus, cortical focal seizures, tonic-clonic seizures S/E Somnolence, agitation, confusion, ataxia, CNS depression, nervousness, nausea, vomiting, constipation, diarrhea, rash
carbamazepine (Tegretol, Carbatrol, Epitol, Equetro) Epilepsy, bipolar disorder, trigeminal/postherpetic neuralgia, S/E Dizziness, nausea, drowsiness, unsteady gait, aplastic anemia and other blood cell abnormalities
carisoprodol (Soma) Relief of discomfort due to acute, painful musculoskeletal conditions, S/E Dizziness, drowsiness, tachycardia, nausea, vomiting
cyclobenzaprine (Flexeril, Amrix) Relief of discomfort due to acute, painful musculoskeletal conditions, S/E : Drowsiness, dizziness, dry mouth, nausea, constipation
diazepam (Valium) Relief of skeletal muscle spasm, spasticity due to cerebral palsy, epilepsy, paraplegia, anxiety, S/E Drowsiness, sedation, sleepiness, lethargy, constipation, diarrhea, bradycardia, tachycardia, rash
colchicine Relief of acute attacks of gout, prevention of gout attacks, S/E Nausea, vomiting, diarrhea, abdominal pain, bone marrow depression
allopurinol (Zyloprim) Management of symptoms of gout, S/E Rash, exfoliative dermatitis, Stevens-Johnson syndrome, nausea, vomiting, diarrhea, abdominal pain, hematologic changes
methotrexate (MTX) (Rheumatrex) RA, cancer chemotherapy, S/E Nausea, stomatitis, alopecia
hydroxychloroquine (Plaquenil) RA, antimalarial, Irritability nervousness, retinal and corneal changes, anorexia, nausea, vomiting, hematologic effects
adalimumab (Humira) RA, other autoimmune disorders, S/E Irritation at injection site, increased risk of infections
ibandronate (Boniva) Postmenopausal osteoporosis, S/E Abdominal pain, nausea, diarrhea
alendronate (Fosamax) Treatment and prevention of postmenopausal osteoporosis; glucocorticoid-induced osteoporosis; osteoporosisin men; Paget’s disease, S/E Abdominal pain, esophageal reflux
Created by: steffieca
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