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Hyperbili/Jaundice
Question | Answer |
---|---|
what does unconjugated bilirubin bind to | albumin |
what is bilirubin conjugation catalysed by | glucuronyl transferase |
in what form is bilirubin excreted in the feaces | stercobilin |
why do neonates get jaundice | immature liver and intestinal processes have decreased glucuronyl transferase |
what is jaundice | a states of hyperbilirubinaemia in excess 250umol/l |
how much bilirubin does a neonate produce on a daily basis | 8-10mg/kg |
what are the three main contributors to jaundice | polycythaemia, enzyme deficiency, diminished liver capacity |
what is the total serum bilirubin level less than for physiological jaundice | 221 umol/l |
what is non-physical jaundice | appears < 24hrs, unconjugated serum bilirubin >250 umol/l |
what are the risk factors for iso-immunisation | syntometrine miscarriage APH |
what is kernicterus | acute or chronic bilirubin encephalopathy |
what is photo-isomerisation | when bilirubin changes shape because its exposed to light |
at what level can bilirubin absorb light | 420-520nm |
what is important to monitor when giving light therapy | temp hydration eye protection |
in what circumstances is an exchange transfusion necessary | when the serum bilirubin indicates it or if acute bilirubinaemia is suspected |