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PG Biomarkers
PG Biomarkers Table handout
Question | Answer |
---|---|
UGT1A1 | Irinotecan & Nilotinib |
UGT1A1*28 | Severe diarrhea, neutropenia |
TPMT | 6-MP inactivation;Increased systemic drug exposure; low/absent = severe life-threatening myelotoxicity(myelosupression) |
CYP3A4/3A5 | Cyclophosphamide; variability in efficacy; enhanced toxicity |
CYP2D6 | Tamoxifen (active metabolite = endoxifen); deficiency leads to reduction of endoxifen and may change toxicity |
ABCB1(MDR1)/ABCB2(MDR2) | Paclitaxel; over expression = drug resistance; wild type = decrease neuropathy |