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CNS Antipsychotics
Top 200 section 1
| Brand | Generic/Available | Class | ADR's | Counseling Points | Dosing | MOA | Indications | CI's/BBWs/Pregnancy Class |
|---|---|---|---|---|---|---|---|---|
| Ritalin/Concerta | Methylphenadate | Indirect sympathomimetic | Insomnia, Headache OD effects • Excessive Sympathomimetic Effects and CNS stimulation | Requires Medication Guide, Chewable Tablets must be taken with adequate water, May sprinkle capsules on applesauce, do not chew or crush, Food can increase absorption, Avoid Alcohol, Apply patch hours before desired affect.Do NOT cut patch | Adult: Agitation, Autism, Bipolar, Depression, Mania, Schizophrenia | • Block catecholamine (DA and NE) reuptake competitively • Stimulates cerebral cortex and subcortical structures similar to amphetamines | ADHD, Narcolepsy | • Hypersensitivity • Idiosyncratic reactions to sympathomimetics • Marked anxiety • Tension • Agitation • Glaucoma • Hyperthyroidism • MAO Inhibitors BBW Drug Dependency, Pregnancy Class C, |
| Cymbalta | Duloxetine | SNRI, Antidepressant | • CNS: Somnolence, HA, Dizziness, Insomnia, Fatigue • GI: Nausea, Xerostomia; Constipation, Diarrhea, ↓Appetite OD Effects • Coma • Hypotension, HTN • Serotonin Syndrome • Seizures • Syncope • Tachycardia • Vomiting • Somnolence | • Dispense with Medication Guide • Swallow whole; do not crush; (enteric coated) • Avoid alcohol • Diabetics should monitor BG; can ↑ glycemic levels | Adult: 60mg Ped: Not approved | • Potent Inhibitor of Serotonin and Norepinephrine Reuptake and Weak inhibitor of Dopamine Reuptake • No MAO Inhibition activity; insignificant Muscarinic, H1-Histaminergic, and α-2-Adrenergic activities. | Acute/Maintenance Tx of Major Depressive Disorder (MDD) Generalized Anxiety Disorder (GAD) Diabetic Neuropathy Pain Fibromyalgia | • MAO Inhibitors (w/in 2 wks or concomitant use) • Uncontrolled Narrow-Angle Glaucoma BBW Suicide Ideation Pregnancy Class C |
| Dexedrine | Dextroamphetamine | Stimulant | CV HTN, Palpitation, Tachycardia, Cardiomyopathy CNS Aggression, Dizziness, Dyskinesia, Dys/Euphoria, HA, Insomnia, Mania, Restlessness,Overstimulation Psychosis GI:Constipation, Diarrhea, Xerostomia, Weight Loss | Take 30 minutes AC and at least 6 hrs before bedtime Drugs may cause physical/psychological dependence Avoid alcohol, caffeine, or OTC stimulants Diabetics should monitor BG; may alter antidiabetic med requirements No breastfeeding | Adult: 10 mg/day, may ↑ 10 mg increments weekly; max 60 mg Peds 3-5 years: 2.5 mg/day, ↑ 5 mg increments weekly; max 40 mg Peds >= 6 years: 5 mg QD-BID; ↑ 5 mg/day increments; 5-20 mg (usual dose); max 40 mg/day | • Noncatecholamine (Sympathomimetic amines) that promote release of catecholamines, mainly dopamine and norepinephrine, from their storage sites in the presynaptic nerve terminals • Minor blockage of reuptake of catecholamines by competitive inhibition | ADHD Narcolepsy | • Hypersensitivity • Advanced arteriosclerosis • Symptomatic CV disease • Moderate-Severe HTN • Hyperthyroidism • Glaucoma • Agitated states • Drug abuse • MAO Inhibitor Tx (w/in 14 days) BBW CV Events Drug Abuse Pregnancy Class C |
| Elavil | Amitriptyline | TCA | CV: Hypotension, Tachycardia, , AV conduction changes, MI, stroke, arrhythmia, HTN, palpitation CNS: Restlessness, Dizziness, Insomnia, Sedation, Fatigue, Anxiety, Cognitive Impairment, Seizure, EPSEs, Coma, Hallucinations, Confusion, HA, Nightmares | |||||
| Fioricet/Esgic | Butalbital/APAP/Caf | Barbiturate | ||||||
| Imitrex | Sumatriptan | 5HT and DA Agonist | ||||||
| Lunesta | Eszoplicone | Hypnotic | ||||||
| Lyrica | Pregabalin | Analgesic, Anticonvulsant | ||||||
| Provigil | Modafinil | Stimulant | ||||||
| Strattera | Atomoxetine | SNRI | ||||||
| Synvisc | Hyaluronate | Antirheumatic, Opthalmic, Viscoelastic, and Skin and Mucous Membrane agent | ||||||
| Valium | Diazepam | Benzo | ||||||
| Vyvanse | Lisdexamfetamine Dimesylate | Stimulant | ||||||
| Wellbutrin/Zyban | Bupropion | Antidepressant | ||||||
| Xanax | Alprazolam | Benzo | ||||||
| Abilify | Aripiprazole | Atypical Antipsychotic | Headache, Agitation, insomnia, Anxiety, Akathisia, Sedation, EPSE, Weight Gain, N/V, Constipation, Dyspepsia OD Effects: Akathisia, EPSE's Somnolence, Tremor, Vomiting | Do not stop abruptly, Avoid Alcohol, Breastfeeding or Pregnancy, Diabetics may cause hyperglycemia, drink fluids, Do not open til ready to take | Adult:10mg-30mg PO qd; max dose 30 mg PO qd Ped:Adolescents: max dose 30 mg PO qd for schizophrenia and bipolar; 15 mg PO qd for autism >= 10 years: 30 mg PO qd for bipolar; 15mg PO qd for autism 6-9 years :15 mg PO qd for autism | While active at both dopamine and serotonin receptors like other antipsychotics, aripiprazole is a partial agonist at the dopaminergic D2 and at the serotonergic 5-HT1A receptors and is an antagonist at the serotonergic 5-HT2A receptor | Agitation, Autism, Bipolar, Depression, Mania, Schizophrenia | Hypersensitivity, Increased Mortality in Dementia Patients, Suicide Ideation, Pregnancy Category C |
| Adderall | Amphetamine Mix | Stimulant | ||||||
| Ambien | Zolpidem | Sedative/Hypnotic | ||||||
| Ancef | Cefazolin | Cephalsporin Antibiotic | ||||||
| Ativan | Lorazepam | Benzodiazapine | ||||||
| Buspar | Buspirone | Anxiolytic(non-benzo) |
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