anesthesia occurs when a “critical region” volume is sufficiently changed. Anesthesia binding to sites on cell mem cause an expansion of the bilayer
What is ED95
ED95= 1.3 MAC of any volatile anesthetic has been found to prevent movement in 95% of patients
Increasing the concentration will _____ the rate of equilibrium of the agent
Speed
Stage I
Amnesia occurs with induction and LOC, no pain remembrance, lightest stage, patient still feels pain
What is MH
Fulminant HYPERMETABOLIC state of skeletal muscle induced by volatile anesthetics, succinylcholine, and, perhaps by stress and exercise
What is compound A
formed from the reaction between Sevo and soda lime, Compound A is a renal toxin, and large amounts are produced at low gas flow ratesRecommended FGF of 2 or more liters, little evidence of harm unless low flows or long exposure
FGF
determined by the vaporizer and flowmeter settings
Factors Affecting Wake Up
Agent used Length of procedure Patient age, mental state, medical conditions, other medications(benzo’s, opiates, neuroleptics, intoxicants)Obesity
Receptor Theory
Enhancement of GABA receptor is thought to be a target in the CNS GABA-A & GABA receptors with a alpha-5-sub-unit.
