Biochemistery of Hemoglobin; Bronchospasm Therapy Medications
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| What are the two(2) CYCLIC NUCLEOTIDES that interact within BRONCHIAL SMOOTH MUSCLE CELLS? | cAMP (adenyl cyclase) & cGMP (guanyl cyclase)
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| What is cAMP and cGMP net physiologic effect on Bronchial Smooth Muscle? | cAMP-B2 andrenergic recepror sites are stimulated, uses Mg2+ to convert ATP to cAMP to result in Bronchodilation.cGMP - A-andrenergic receptors stimulated , coverts guanosine triphosphate (GTP) to cyclic GMP
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| What does the A-andrenergic blockade drugs do? | Influences the biochemical event of preventing guanyl cyclase activation which PREVENTS bronchoconstriction
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| What does B2-andrenergic stimulation drugs do? | influences the biochemical event of adenyl cyclase activation causing brochodilation
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| What is the purpose of a Phosphodiestrase inhibition medications? | influences the biochemical event prevents dehydration of cyclic AMP to 5-AMP, thus keeping it active longer which PREVENTS the chance of bronchoconstriction.
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| Whis is the main use of cholinerginergic stimulation medications? | influences the biochemical event guanyl cyclase activation resulting in bronchoconstriction.
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| Describe the significance of antigen-antibody reactions on the surface of the mast cell? | When exsposure of an appropriate antigen occurs (2 IgE molecules) of the same specificity, the antibody reaction triggers the biochemical sequence that leads to mast cell degranulation.
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| ALBUTEROL( Ventolin,Proventil) | B2 stimulation; adenyl cyclase activation, increase in cyclic AMP
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| BITOLTEROL(Tornalate) | B2 stimulation; adenyl cyclase activation, increase in cyclic AMP
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| PIRBUTEROL(Maxair) | B2 stimlation; adenyl cyclase activation, increase cyclic AMP
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| TERBUTALINE(Brenthine,Brieanyl) | B2 stimulation; adenyl cyclase activation, increase in cyclic AMP
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| EPINEPHRINE(Adrenaline) | B2 stimulation(cardiac);adenyl cyclase activation, increase in cyclic AMP
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| IPRATROPIUM BROMIDE(Atrovent) | Cholinergic Blockade;prevents guanyl cyclase activation,decrease cGMP
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| OXYTOPIUM BROMIDE(Spiriva) | cholinergic blockade; prevents guanyl cyclase activation,decreses in cGMP
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| PHENTOLAMINE | A-BLOCKADE(CARDIAC); PREVENTS guanyl cyclase, Deacrease cGMP
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| TOLAZOLINE(priscoline) | A-BLOCKADE;PREVENTS guanyl cyclase, decrease cGMP
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| ZAFIRLUKAST(Accolate) | LEUKOTRIENE MODIFIER;ANTI-INFLAMMATION,BRONCHODILATION
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| MONTELUKAST(Singulair) | LEUKOTRIENE MODIFIER; ANTI-INFLAMMATION, BRONCHODILATION
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| ZILEUTON(zyflo) | LEUKOTRIENE MODIFIER; 5' lipoxygenase inhibitor
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| CROMOLYN SODIUM(Intal) | BLOCKS ANTIGEN-ANTIBODY REACTION; PREVENTS MAST CELL DEGRANULATION AND MEDIATOR RELEADE
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| NEDOCROMIL(Tilade) | BLOCKS antigen-antibody reaction; PREVENTS mast cell degranulation and mediator release
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| METHYLXANTHINES(Theophyline,caffene,Theobromide,Aminophylline) | PHOSPHODIESTERASE inhibition; prevents degradation of cyclic AMP to 5'- AMP; increases cAMP
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| ATROPINE | BLOCKS cholinergic-induced bronchospasm,bronchodilatory action
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| TERBUTALINE | B2 agonist stimlation during a bronchospasm
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| Relate the utility of cromolyn for the treatment of asthma. | non-steriodal medication (anti-inflammatory) can reduce the need for quick relivers and reduce bronchial hyperrespnsiveness. also can improve morning peak flow and decrease symptoms of nocturnal asthma
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| Describe the make-up of methemoglobin? | Ferrous ion (Fe2+) in the heme portion of hemoglobin becomes oxidized to the ferric state (Fe3+);tyrosine substitutes histidine in either A or B chain in the Globin protion of the hemeglobin molecule. tyrosine causes ferrous ion to oxidize to ferric state
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| How does mehemoglobin affect tissue oxygenation? | I
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| Oxygen attachment on hemoglobin? | Pyrrole Ferrous ion(heme portion)
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| Attachment od CO2 on hemoglobin? | Teminal Amine group Globin portion
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| Attachment of H+ on hemoglobin? | imidazole group on deoxygenated hemoglobin
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| Discuss how coperativity enhances the binding of oxygen to hemoglobin at the lungs and how it facilitates the release of oxygen to the cells at the tissues? | Cooperativity ehances bonding of oxygen by increasing bonding potentional. Conversely, at the tissue level the unloading of oxygen molecule facilitates the release at oxygen at the other sited
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| 4 factors that inflence oxygen- hemoglobin affinity? | body temp. , PaCO2, Arterial pH, 2-3-DPG
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| Define Bohr Effect: | Effect of Carbon Dioxide or (H+) pn uptake and relase of oxygen from the hemoglobin(effect mild)
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| Define Haldane Effect: | influence of CO2 binding and unbinding on the release and uptake of oxygen , respectively, by the hemoglobin molecule
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