rad bio U5
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| What are the names of the 2 frenchmen that performed tests to try and discover why cells reacted differently to radiation? | bergonia and tribondeau
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| What is the law that defines sensitivity in terms of specific characteristics of cells studied? | the law of bergonia and tribondeau
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| What are the two parts of the study of this law? | mitotic activity and differentiation
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| What is this law based on? | the inherent cellular characteristics and not on radiation
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| What is the exception to this law? | lymphocytes
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| The more often a cell goes through mitosis the more sensitive it is because, the cell is more sensitive while it is reproducing is called? | mitotic activity
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| A differentiated cell is one which is specialized in functionally and/or morphologicallly(structured) | differentiation
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| the more differentiated a cell is the | more radio resistent it is
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| Describe why the male reproductive organ is listed as radiosensitive organ but sperm is radioresistant | The sperm starts out as the spermatagonia A which is very radsensitive because it is very undifferentiated and if you destroy that cell you will destroy future cells because the sperm cells will never develop because you have taken out the ancestral cells
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| What type of cell is an erythrocyte? | a differentiated cell when it mature and is radioresistant
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| What type of cell is an erythroblast? | radiosensitive
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| What does cellular sensitivity depend on | understanding the characteristics of various cell population
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| list the 5 caterories of cell population | Vegatative intermitotic cells(VIM),Differentiating intermitotic ells(DIM),Multi potential connective cells,reverting posrmitotic cells(RPM), fixed postmitotic cells(FPM)
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| Give the descriptin of VIM cells | rapidly dividing, indifferentiated and most sensitive group
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| Give the description of DIM cells | produced by the division of VIM, actively mitotic, more differentiate than VIM, and less sensitive than VIM
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| Give examples of VIM | basal cells of epidermis, crypts cells, type A spermatogonia, and erythroblast
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| give example of DIM cells | type B spermatogonia
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| give description of multi potential connective cells | cells divide irregularly, more differentiated than VIM and DIM, intermediate in senstivity
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| Give example of multi potential cannective cells | endothelial cells(lines blood vessels) and fibroblasts(connective tissue)
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| give the description of the RPM cells | normally do not undergo mitosis but can divide under special conditions, more differentiated than the other 3, relatively radioresistant
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| give example of RPM cells | mature lymphocytes(radiosensitive) and liver cells
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| give description of FPM cells | do not divde, highly differentiated and most resistant to radiation
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| give examples of FPM | nerve cells, muscle cells, erythrocytes and spermatozoa
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| What the most sensitive to radiation cells | lymphocytes, spermatogonia,erythroblasts, and intestinal crypt cells
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| what are intermediate radiation sensitive cells | endothelial cells, osteoblats, spermatids, and fibroblasts
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| what are low radiation sensitive cells | muscle, nerve and chondrocyte cells
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| What are the two compartments that the tissue and organs are made of | parenchyma and stromal
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| contains cells characteristics of that individual tissue or organ | parenchyma
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| the connective tissue and vasculature which supports the organ | stromal
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| These can be directly destroyed | parenchyma
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| these can be constricted or destroyed which supplies parenchyma | vascular(Stroma)
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| loss of cells is called | hypoplasia
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| These are the high radiosenstive organs | lymphiod organs, bone marrow, testes, ovaries, and intestine
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| these are the fairly high radiosenstive organs | skin and other organs with epithelial call lining(cornea, oral cavity, esophagus,rectum, bladder, vigina,, cervix, ueters) optic lens, stomach
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| These are the medium radio sensitive organs | growing cartilage, fine vasculation, growing bone
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| These are the fairly low radiosensitive organs | mature cartilage or bone, salivarly glands, respiratory organs, kidneys, liver, pancreas, thyroid, adrenal and pituitary glands
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| These are the low radiosenstive organs | muscle, brain, spinal cord
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| modification of radiation reponse by external factors and give example | conditional sensitivity; chemicals
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| what is the amount of days of life lost on each:smoking, overwieght by 20%,all accidents, average alchol use, natural background and 1rem/yr | (DAYS)2370,850, 435, 130, 8, 30
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