Coagulation Drugs
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| show | Heparin
LMWH- low molecular weight heparin
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| LMWH drugs | show 🗑
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| show | Aspirin (Bayer, Ecotrin)
Dipyridamole (Persantine)
Cilostazo (Pletal)
Ticlopidine (Ticlid)
Clopidogrel (Plavix)
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| show | Abciximab (Repro)- monoclonal antibody
Eptifibatide (Integrilin)- cyclicpeptide
Tirofibam (Aggrastat)- nonpeptide
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| show | Urokinase
Tissue plasminogen activators (t-PA, rt-PA)
Streptokinase
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| show | Ind: tx and prevention of thromboembolic disorders
MOA: binds to antithrombin III and exposes antithrombin II site; inactivates II, VII, IX, X and plasmin and prevents the conversion of fibrinogen to fibrin. Works in the blood
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| Heparin ADR | show 🗑
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| show | Active bleeding, hemophilia, ulcers, thrombocytopenia, intercranial hemorrhage, visceral carcinoma, during or before lumbar puncture or regional anesthetic blocks, following brain, spinal cord, or eye surgery
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| show | aPTT (6-8 hrs after start and following any change in rate) platelet counts, H&H, person's own heparin levels
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| LMWH MOA | show 🗑
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| show | thrombocytopenia, hemorrhage, local irritation, bruising
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| When administerin LMWH, what must be monitored? | show 🗑
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| show | Pts with epidural or spinal anesthesia.
If administered to someone with an epidural catheter, the catheter should be removed prior to the next dose.
May cause bleeding or hematomas to form on the spinal column and may lead to paralysis.
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| Lovenox | show 🗑
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| High-Risk patients to be considered for Lovenox tx after abdominal surgery | show 🗑
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| show | LMWH
Dalteparin
Ind: Prevention of DVT following abdominal surgery, hip or knee replacement, prevention of ischemic complications with acute coronary syndromes.
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| show | LMWH
Ardeparin
Ind: Prevention of DVT following knee replacement surgery
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| show | LMWH
Coumadin
Ind: Prophylaxis and tx of thromboembolic disorders: a.fib w risk of embolism; prophylaxis of systemic embolism after MI; prevention of recurrent TIA/stroke.
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| show | hemorrhage, skin necrosis, alopecia, N/V, mouth ulcers
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| Warfarin MOAs | show 🗑
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| Drug interactions that increase Warfarin response | show 🗑
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| Drug interactions that decrease Warfarin response | show 🗑
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| show | INR 2-3 (2.5-3.5 in valve replacement)
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| show | Protamine sulfate
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| Antidote of Warfarin | show 🗑
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| show | Antiplatelet drug
Ind: prophylaxis of MI, TIA/stroke
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| Aspirin MOA | show 🗑
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| Aspirin dose for pts with low risk for embolism following AMI | show 🗑
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| Aspirin dose for pts with unstable angina | show 🗑
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| Aspirin dose for pts with clinical or laboratory evidence of CAD or stable angina | show 🗑
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| Aspirin dose for men or women 50 or older with at least one risk factor for CAD | show 🗑
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| show | 50-325 mg/day
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| Persantine | show 🗑
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| show | Pletal
Antiplatelet
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| Antiplatelet (persantine and pletal) MOA | show 🗑
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| Antiplatelet (ticlid and plavix) MOA | show 🗑
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| Ticlid | show 🗑
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| Plavix | show 🗑
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| show | Reduction of atherosclerosis events (MI, stroke) in patients with atherosclerosis documented by recent MI, stroke, or extablished peripheral arterial disease; Use after interventional cardiac catheterization to prevent platelet aggregation.
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| Ticlopidine ADR | show 🗑
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| Clopidogrel ADR | show 🗑
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| Glycoprotein IIb-IIIa inhibitors Ind | show 🗑
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| Eptifibatide (Integrilin) MOA | show 🗑
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| What is the anticoagulation DOC for pregnant women? | show 🗑
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| Abciximab (Repro) MOA | show 🗑
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| show | Tirofiban
Glycoprotein IIb-IIIa inhibitor
Nonpeptide
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| show | Abciximab
Glycoprotein IIb-IIIa inhibitor
monoclonal antibody
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| Integrilin | show 🗑
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| Abboinase | show 🗑
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| show | Tissue plasminogen activators, Ateplase, t-PA
Fibrinolytics that activate fibrin bount plasminogen
Ind: tx of coronary artery thrombosis (MI), PE, and stroke
VERY EXPENSIVE
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| Kabikinase | show 🗑
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| Fibrinolytics | show 🗑
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