health promo_genetic
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| Gene | show 🗑
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| show | processes to correct defective genes by either replacing, repairing or regulating the defective gene.
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| Genetics | show 🗑
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| Genome | show 🗑
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| show | the study of genomes, including interaction between genes, between genes and environment & looks at total DNA structure
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| show | study of inherited differences in drug metabolism response
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| Pharmacogenomics | show 🗑
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| Phenotype | show 🗑
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| Proteomics | show 🗑
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| Public Health Genomics (PHG) is defined as | show 🗑
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| show | All humans are 99.9% identical at the DNA level.
The environment causes most genetic mutations.
Public health nurses need to be able to identify the elements that may cause genetic mutations.
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| show | uses new methods of molecular analysis to better manage a patient’s disease or predisposition toward a disease. It aims to achieve optimal medical outcomes by helping physicians and patients choose the disease management approaches likely to work best in
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| Personalized Health Care continued | show 🗑
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| show | Goal = improve safety, quality and effectiveness of health care.
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| show | Demonstrate basic knowledge of the role that genomics plays in the development of disease.
Identify limits of his or her genomic expertise.
Make appropriate referrals to those with more genomic expertise.
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| Competencies identified by National Coalition of Health Professional Education in Genetics (NCHPEG) | show 🗑
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| Human genome project | show 🗑
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| show | Determine the sequence of 3 billion chemical base pairs that make up DNA.Improve tools available for data analysis. Transfer genetic technology to the private sector. Research the ethical, legal and social implications on genetic testing and research.
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| single nucleotide polymorphism (SNP) | show 🗑
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| IMPACT ON NURSING | show 🗑
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| show | Thiopurine agent, 6 –mercaptopurine = drug and
Thiopurine methyltransferase = enzyme needed to inactivate drug. Kids with nonfunctioning TMPT alleles suffer sever toxicity to Thiopurine (need 1/10 dose)
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| show | .1st drug in history to include pharmacogenomic instructions on its label. Prescriptions are tailored to the genetic make-up of the child
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| Gene therapy: | show 🗑
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| gene therapy goal | show 🗑
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| Gene therapy humulin insulin | show 🗑
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| show | DNA extracted from blood sample, and applied to CYP450 genetic results sends results to MD or NP or place on a smart card for you to keep in your wallet.
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| Roche Amplichip Cytochrome P450 Genotype testing available now –continue | show 🗑
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| show | The easiest tool to use is the PEDIGREE
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| genetic risk assessment | show 🗑
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| show | Healthy People 2020: G-2 increase the proportion of persons with newly diagnosed colorectal cancer who receive gentic testing. G-1 breast or ovarion receives genetic counseling
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| ETHICAL, LEGAL AND SOCIAL ISSUES IN GENETIC AND GENOMIC PRACTICE | show 🗑
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| show | Tuskegee - syphillis - longitudal study - following men with syphillis at first no antibiotec then one came out but did not treat the men in the longitudal study. Nurse in the study blew the whistle.
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| show | eugenics->Encouraged “fit” to reproduce and “unfit” to not. Segregation of the genetically unfit into institutions. 1900-10 -forced sterilizations. 1927-MR sterlized. Nazi movement.
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| Unsavory past of genetic testing | show 🗑
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| Sickle cell testing | show 🗑
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| show | Deciding whether to restrict a study to a specific racial/ethnic group involves the ethical principle of justice.
NIH Health Revitalization Act of 1993 is US Federal law which requires that results of clinical trials include women and minorities.
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| show | If a “bad gene” is discovered in an ethnic group, specific communities may suffer discrimination and stigmatization.This brings into affect the ethical principles related to group harm.
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| Discrimination and stigmatization In pharmacogenomics | show 🗑
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