Cardiovascular system pharmacology- Drugs used in Heart Failure
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Objectives of Long Term Management of Chronic Cardiac Failure: | show 🗑
|
||||
| show | Reduced force of contraction
Decreased CO
Increased total peripheral resistance
Inadequate organ perfusion
Edema
Decreased exercise tolerance
IHD
Sudden death
Ventricular remodeling and decreased function
🗑
|
||||
| What are the non-pharmacologic treatments of Heart Failure? | show 🗑
|
||||
| show | Diuretics
Aldosterone receptor antagonists
Angiotensin-converting enzyme inhibitors
Angiotensin receptor blockers
Beta blockers
Cardiac glycosides
Vasodilators
Beta agonists
Bipyridines
Natriuretic peptide
🗑
|
||||
| show | They mostly treat the congestive symptoms
Decrease BP and increase K+ loss
Can be used in combination with digitalis
🗑
|
||||
| show | IV
🗑
|
||||
| What are the causes of diuretic resistance in HF? | show 🗑
|
||||
| show | Reduce A II levels
Increase bradykinin
Decreased NE release and upregulation of B1 receptors
Reduction of afterload and preload
Reduce myocyte & fibroblast GFs
Decrease aldosterone causing decreased fluid retention, K+ loss, and arrhythmias
🗑
|
||||
| What is the therapeutic value of ACEIs? | show 🗑
|
||||
| What are the different preparations of ACEIs? | show 🗑
|
||||
| show | Hypotension - First dose phenomenon
Renal Impairment - Proteinurea
K+ retention
Cough
🗑
|
||||
| show | Losartan
Candesartan
Valsartan
Irbesartan(Approvel)
Telmisartan(Micardis)
🗑
|
||||
| When are ARBs used? | show 🗑
|
||||
| show | Negative inotropic
Not useful in refractory HF
Slowing of HR, decreased cardiac work and consequently decreased myocardial O2 consumption and enhanced efficiency lessen the frequency of ischemic events and arrhythmias
🗑
|
||||
| How can Beta blockers improve myocardial contractility? | show 🗑
|
||||
| How are Beta blockers administered? | show 🗑
|
||||
| Examples of Beta blockers: | show 🗑
|
||||
| When are beta blockers contraindicated? | show 🗑
|
||||
| show | By increasing intracellular cardiac Ca++ concentration
🗑
|
||||
| Examples of Cyclic AMP Independent Agents: | show 🗑
|
||||
| Examples of Cyclic AMP Dependant Agents: | show 🗑
|
||||
| show | Inhibits Na/K ATPase
🗑
|
||||
| Action of Pimobendan: | show 🗑
|
||||
| show | Digitalis purpura
Digitalis lanata
Strophanthus
🗑
|
||||
| Further action of Digitalis glycosides: | show 🗑
|
||||
| Effects of Digitalis Toxicity: | show 🗑
|
||||
| Pharmacological and toxic effects are greater in | show 🗑
|
||||
| show | K+-depleting diuretics
🗑
|
||||
| show | Reduce or stop the drug
Cardiac pacemeker for heart block
Digitalis antibodies
Arrhythmias may be converted to normal sinus rhythm by K+
Antiarrhythmic drugs, such as lidocaine, phenytoin, procainamide, or propranolol, used when K+ conc is high
🗑
|
||||
| show | Only useful in CCHF with supraventricular arrhythmia
Might decrease morbidity
🗑
|
||||
| Examples of B-adrenergic agonists (which are cAMP dependent agents): | show 🗑
|
||||
| show | Amrinone
Inamrinone
Milrinone
Vesanirone
Sildenafil
Adorable Ideas Meet Slimy Verbs
🗑
|
||||
| show | All increase myocardial oxygen consumption, may be used (IV) for short term or in acute heart failure
🗑
|
||||
| show | In cardiogenic shock, but caused severe vasospasm and gangrene
🗑
|
||||
| When is Ep used? | show 🗑
|
||||
| show | Widely used in cardiogenic shock
🗑
|
||||
| Low doses of dopamine cause: | show 🗑
|
||||
| show | Positive inotropic actions by working on B1 receptors
🗑
|
||||
| show | Stimulation of α receptors leading to vasoconstriction and elevation of blood pressure
🗑
|
||||
| Side effects of dopamine: | show 🗑
|
||||
| What is dobutamine? | show 🗑
|
||||
| When is dobutamine used? | show 🗑
|
||||
| General function of phosphodiesterase inhibitors: | show 🗑
|
||||
| Phosphodieserase inhibitors are generally used for: | show 🗑
|
||||
| Examples of phosphodiesterase inhibitors: | show 🗑
|
||||
| Toxicity, as a result of phosphodiesterase inhibitors leads to: | show 🗑
|
||||
| show | Affect preload and/or afterload without directly affecting contractility
Consequently can decrease myocardial ischemia, enhance coronary blood flow and decrease MVO2
🗑
|
||||
| When are vasodilators used? | show 🗑
|
||||
| show | Decrease mortality
Reducing remodeling of the heart
🗑
|
||||
| show | ACEI, diuretics and digitalis
🗑
|
||||
| show | Nitroglycerin
Isosorbide dinitrate
🗑
|
||||
| Mixed action vasodilators: | show 🗑
|
||||
| Atrial dilators: | show 🗑
|
||||
| show | Nitroglycerin
Isosorbide dinitrate
🗑
|
||||
| Examples of Nitric oxide donors used for vasodilators | show 🗑
|
||||
| show | Captopril
Enalapril
Lisinopril
🗑
|
||||
| show | Losartan
candesartan
🗑
|
||||
| show | Milrinone
Inamrinon
🗑
|
||||
| show | Hydralazine
Minoxidil
🗑
|
||||
| show | Doxazosin
Prazosin
🗑
|
||||
| show | Phentolamine
🗑
|
||||
| B1-adrenergic antagonists used for vasodilators : | show 🗑
|
||||
| Ca2+ channel blockers used for vasodilators | show 🗑
|
||||
| show | Binds to receptors in the vasculature, kidney, and other organs, producing potent vasodilation with rapid onset and offset of action by increasing levels of cGMP
🗑
|
||||
| BNP is secreted by: | show 🗑
|
||||
| Niseritide is used for the treatment of: | show 🗑
|
||||
| Action of niseritide: | show 🗑
|
||||
| show | Reduction in preload and afterload
🗑
|
||||
| show | Hypotension
🗑
|
||||
| show | Improper dosage of diuretics
Failure to consider long term therapeutic goals
Underprescribing ACEIs
Use of potentially harmful drugs
Failure to use hydralazine-isosorbide combination
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
Ulaisl
Popular Pharmacology sets