Inclusion bodies and anomalies
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| How do you do a corrected WBC count? | show 🗑
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| What does an NRBC look like? | show 🗑
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| Why is it important to note the presence of NRBCs? | show 🗑
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| show | residual rRNA.
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| show | New Methylene blue
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| show | When a person is being treated for anemia and hemolytic anemias.
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| What are Howell-Jolley bodies composed of? | show 🗑
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| What organ usually removes them and why would it cease to do this function? | show 🗑
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| What disease processes could result in this howell-jolly inclusions? | show 🗑
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| show | Lead poisoning.
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| show | Spontaneous aggregation of ribosomal RNA; Wright's stain
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| show | bluish compared to regular RBCs and also slightly larger
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| show | Iron
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| show | Prussian blue
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| show | Iron
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| show | Pappenheimer bodies
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| show | Hemoglobinopathies, hemolytic anemias, sideroblastic anema, post-splenectomy
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| show | Heinz bodies are composed of denatured hb. They are large and rigid and cause distortion of the RBC
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| What diseases can cause Heinz bodies? | show 🗑
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| What stain shows the heinz bodies? | show 🗑
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| show | they look like funny shaped rbcs...almost like unevenly distributed burr cells.
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| Cabot rings look like what under the wright's stain? | show 🗑
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| show | Arginine rich histones and non-hgb iron.
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| show | homozygous thalassemia, megaloblastic anemias, post-splenectomy; the cause of their formation is unknown.
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| What stain is used to visualize malaria? And what is this considered for malaria diagnosis? | show 🗑
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| show | A serious bacterial infection. Vacuoles are not usually seen in neutrophils.
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| When you see toxic granules and Dohle bodies in the neutrophils what does that indicate? | show 🗑
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| Toxic granules and Dohle bodies are considered? | show 🗑
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| show | Yes and they're graded.
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| What condition would cause toxic vacuolization? | show 🗑
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| show | glycogen and rER.
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| What conditions are associated with Dohle bodies? | show 🗑
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| Define leukocytosis. | show 🗑
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| show | Bacterial infections
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| show | Leukamoid reaction.
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| What causes a white cell count greater than 100,000? | show 🗑
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| show | The white cell count as well as the amount of immaturity. In leukemia there is a shift to the left and immature cells are seen within the bloodstream. Also leukamoid rxn is transient and will disappear once the stimulus is removed.
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| show | Vigorous exercise, temp increase, labor/delivery, intense emotional distress.
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| show | HIV+ pt's
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| Define hypersegmented. What causes them? | show 🗑
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| show | Megaloblastic anemia, pernicious anemia, folic acid deficiency
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| show | Azurophilic granular materials
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| show | A reddish rod found in myeloid blasts; AML
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| show | it is the irreversible condensation of chromatin in the nucleus undergoing cell death or apoptosis.
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| show | Mononucleosis.
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| show | Increased count plus reactive lymphs
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| show | Treponema pallidium, Epstein-Barr Virus, CMV, Toxoplasmosis, S. agalactiae, Hep C, Hantavirus
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| show | Chronic lymphoid leukemia; the b-cell (it's a mature B-cell neoplasm)
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| Ehrlichia is transmitted by? What does it look like on a smear? | show 🗑
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| What has PAS-positive vacuoles and what condition is associated with it? | show 🗑
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| What are five factors associated with acquired neutropenia? | show 🗑
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| What is characteristic of aplastic anemia? | show 🗑
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| Name the defect classifications of qualitative neutrophil disorders. | show 🗑
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| Why is Chediak-Higashi syndrome so severe? What are the symptoms? | show 🗑
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| What causes CGD? | show 🗑
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| What are the symptoms of CGD? | show 🗑
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| show | nitroblue tetrazolium test (NTB) or by measuring the resp. burst activity via flow cytometry
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| What is characteristic of Pelger-Huet anomaly? Is this condition severe? | show 🗑
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| What is an Alder-Reilly inclusion body? What is it associated with? | show 🗑
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| What is a May-Heglin body composed of? How can it be differentiated from a Dohle body? | show 🗑
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| show | An inborn error involving apolipoprotein E which leads to abnormal lipid metabolism. It causes an accumulation of glycosphingolipids in the histiocytes. It can be visualized by using May Grunwald staining (bm or spleen aspirations).
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| What is a major symptom of Gaucher's disease? | show 🗑
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| show | It is an inherited disease which causes a deficiency in an acid called beta-glucosidase which makes the marcophages unable to breakdown the lipids they ingest from phagocytosis.
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| show | Caused by a missing enzyme: sphingomyelinase which normally breaks down lipids. It causes foamy macrophages which are easy under the microscope.
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| What are the symptoms of Niemann-Pick disease? | show 🗑
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| What is an easy way to tell if lymphocytes are part of a malignant disorder or reacting to viral infection? | show 🗑
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| show | Mono heterophile antibodies
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| show | Toxoplasma gondii; serological antibody tests; It can cause problems for the fetus (hydrocephalic); can get infected by cat feces or undercooked meat.
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| show | CLL, ALL, CMV, infectious lymphocytosis, Bordetella pertussis, lymphocytic leukamoid rxn.
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| show | AIDS, SCIDS, Digeorge syndrome, Sex-linked agammaglobulinemia
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| Symptoms of plasmacytosis. Where are they found in this condition? | show 🗑
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| What is basophilia associated with? | show 🗑
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| WHat is monocytosis associated with? | show 🗑
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| What can neutropenia be caused by? | show 🗑
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| What is agranulocytosis caused by and what is the count like? | show 🗑
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| WHen is leukoerythroblastic reaction occur? | show 🗑
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| What does a person with myeloperoxidase deficiency lose the ability to do? | show 🗑
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| MPO deficiency is commonly seen is people with? | show 🗑
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| How can you tell the difference between an acute and chronic leukemia based on the blood smear? | show 🗑
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