anti-anxiety
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| Benzodiazepines are most commonly used ____________ medication | anti-anxiety
🗑
|
||||
| They are also grouped in ____________ medication | sedative-hypnotic
🗑
|
||||
| They are also classified as centrally mediated ____________ ____________ | muscle relaxants
🗑
|
||||
| Mechanism of action: CNS depression specific to the areas in ____________, _________ and ______ system of the brain | hypothalamic, thalamic, limbic
🗑
|
||||
| Indications | anxiety relief, sedation, anticonvulsant, muscle relaxants, appetite stimulant, retrograde amnesia
🗑
|
||||
| Sedative effects through depression of | limbic system
🗑
|
||||
| Muscle relaxing effect via inhibiting of the ______ at the spinal level | internunical neurons
🗑
|
||||
| There are two major inhibitory amino acid neuro transmitters in the CNS= | glycine and gamma-amino-butyric acid (GABA)
🗑
|
||||
| _______ performs inhibitory function in the spinal cord, brain stem and retina. | glycine.
🗑
|
||||
| GABA is found in the __________ and _________ | cerebrum and cerebellum
🗑
|
||||
| Benzodiazepines action is through _________ of specific (BZ) receptors | stimulation
🗑
|
||||
| There are as many as __________ variations of BZ receptors | 6
🗑
|
||||
| How many categories of action can be identified | 3
🗑
|
||||
| Agents which _________ _________ bindings and - induced ___________ current are known agonist. | increases GABA, chloride
🗑
|
||||
| Drugs that reduce ______ ______ binding and induce _______ _______ are known as inverse agonists. | both GABA, chloride influx
🗑
|
||||
| Drugs that reduce both GABA and induce Chloride influx are known as | inverse agonists
🗑
|
||||
| inverse agonists are responsible for | anxiety, convulsion and analeptic properties
🗑
|
||||
| The third group the genuine antagonist of both agonist and inverse agonist are drugs that bind but have no efficacy at the site, _________ is a drug of this type | flumazenil
🗑
|
||||
| How many types of GABA receptors are found at pre and post synaptic site | 2
🗑
|
||||
| what are the GABA type of receptors found at pre and post synaptic site. | A & B
🗑
|
||||
| Important to remember is that Benzodiazepines potentates the action of __________ and increases the frequency of _________ channel opening. | GABA, Chloride (Cl)
🗑
|
||||
| Benzodiazepines derivatives are | Diazepam, Midazolam, Chloradiazepoxide, Lorazepam, Alprazolam, Clonazepam, Zolazepam, Chlodiazepam.
🗑
|
||||
| Which Benzodiazepines are used in Veterinary Medicine | Diazepam, Midazolam, Zolazepam, Chlodiazepam
🗑
|
||||
| What are the common names for BZ used in Veterinary Medicine | Valium, Versed, Zolazepam, Chlodiazepam
🗑
|
||||
| How many BZs are we learning about | 8
🗑
|
||||
| How many BZs are used in Veterinary Medicine | 4
🗑
|
||||
| What is the acronym for the BZs use in Vet Med. | DMZC
🗑
|
||||
| Name for Diazepam | Valium
🗑
|
||||
| Name for Midazolam | Versed
🗑
|
||||
| Name for Chloradiazepoxide | Librium
🗑
|
||||
| Name for Lorazepam | Ativan
🗑
|
||||
| Name for Alprazolam | Xanax
🗑
|
||||
| Name for Clonazepam | Klonopin
🗑
|
||||
| This drug is insoluble in water, solution contains solvent propylene glycol, ethanol and sodium benzoate in benzoic acid | Diazepam
🗑
|
||||
| IV injection of __________ can cause thrombophlebitis. | Diazepam
🗑
|
||||
| Can Diazepam be used orally? | Yes
🗑
|
||||
| Which of these can Diazepam pass through? the blood-brain barrier or placental barrier | Both
🗑
|
||||
| What percent of Diazepam is protein bound | almost 90%
🗑
|
||||
| Diazepam's half life is | 6 to 21 hours
🗑
|
||||
| How is diazepam metabolized | in the liver by demethylation and hydroxylation
🗑
|
||||
| In the liver diazepam is demthylated and hydroxylated to how many forms | 3
🗑
|
||||
| what are the active forms of diazepam demethylated and hydroxylated by the liver | N-demethyldiazepam, 3-hydroxydiazepam and oxazepam
🗑
|
||||
| Diazepam metabolites are conjugated to ________ by the liver. | glucuronide
🗑
|
||||
| Glucuronide is excreted by | Kidneys
🗑
|
||||
| Is the toxcity of Diazepam low or high | low
🗑
|
||||
| How do you treat an overdose of Diazepam | with flumazenil
🗑
|
||||
| Clinical Uses for Diazepam include | convulsion control, used in dog, cat, horse to prevent post-op convulsion caused by use of contrast media into spinal cord for radiography, premedication for sedation, etc
🗑
|
||||
| Diazepam has been used as muscle relaxation with what other drugs to perform minor surgical procedures | ketamin, xylazine, opiods, etc
🗑
|
||||
| This drug is water soluble and not painful given IV | Midazolam
🗑
|
||||
| Midazolam is metabolized by | the liver
🗑
|
||||
| what is the half life of Midazolam | shorter than Diazepam
🗑
|
||||
| Midazolam effects on repiratory and cardivascular are | minimal like others in the group
🗑
|
||||
| Midazolam are used widely with combinations of | opioids
🗑
|
||||
| Does Midazolam readily cross the blood-brain barrier | yes
🗑
|
||||
| which is more potent Midazolam or Diazepam | Midazolam
🗑
|
||||
| Midazolam clinical uses include | anticonvulsant, muscle relaxant, appetite stimulant
🗑
|
||||
| what is the acronym for Midazolam clinical uses | the AMA
🗑
|
||||
| Midazolam is combined with | ketamine and other anesthetics
🗑
|
||||
| Diazepam and Midazolam can cause what type of changes in dogs and cats | behavior
🗑
|
||||
| Midazolam can cause these animals restless, to pace, vocalize, and difficult to approach | cats
🗑
|
||||
| can midazolam cause an increase or decrease in food consumption | increase
🗑
|
||||
| what drug antagonizes the effects of all benzodiazepines | flumazenil
🗑
|
||||
| what is another name for flumazenil | romazicon
🗑
|
||||
| what action speed of flumazenil | rapid 2 to 4 minutes
🗑
|
||||
| Reversal by flumazenil is or is not accompanied by anxiety and cardiovascular effects | is not
🗑
|
||||
| how long does the antagonistic effects of flumazenil effects last | about 60 minutes
🗑
|
||||
| should you ever redose flumazenil | yes it may be required
🗑
|
||||
| Zolazepam is sold in combination with | tiletamine
🗑
|
||||
| in what ration is zolazepam and tiletamine sold in | 1 : 1
🗑
|
||||
| what is the combination of zolazepam and tiletamine called? | telazol.
🗑
|
||||
| Telazole contains what | 250mg of zolazepam and 250mg of tiletamine
🗑
|
||||
| tiletamine is a dissociative agent similar to | ketamine
🗑
|
||||
| Telazole is widely used in | ruminants
🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
alljacks
Popular Veterinary sets