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#5-Dobrisky-Substance Abuse

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Question
Answer
Physical dependence   a characteristic that is present when withdrawal of the drug results in physiological disruptions  
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Withdrawal symptoms   biological need that develops when body adapts to having the drug in the system; a substance specific syndrome  
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Tolerance   with continued use, more of the substance is needed to produce the same effect  
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Substance abuse   A maladaptive pattern of substance use leading to clinically significant impairment or distress  
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Substance dependence   Similar definition but involves tolerance and withdrawal  
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Polysubstance abuse   simultaneous or sequential use of more than one substance  
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Cross-tolerance   increasing need for drugs of similar composition  
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Dual diagnosis   When a person has two identified primary psychiatric diagnosis—most commonly used when one dx is drug or alcohol related  
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Gateway drugs   Substances implicated as forerunners topolysubstance use or drug dependence  
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Individual risk factors   age, ethnicity, genetic predisposition; co-morbidities; stress  
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situational risk factors   peer influence; social norms; family influences; support system  
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environmental risk factors   access to and cost of substance; severity of punishment  
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neurobiologic basis of addiction is   rapid release of neurotransmitters, followed by a reduced-from-baseline level  
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dopamine levels change how when drugs are used?   increase  
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glutamate is associated with   addiction  
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which cultures and ethnic groups is substance abuse more prevelant?   found in all cultures and ethnic groups  
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substance abuse is viewed differently depending on...   the substance being used, the person using it and the setting in which it is used  
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when people are displaced from their original cultures what happens to their risk for abuse?   it rises  
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barbiturates, benzodiazepines and alchohol are all   depressants  
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hypnotics are   cns depressants  
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all prescription sleeping medications, antianxiety medications, and barbiturates are considered to be   cns depressants: hypnotics  
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what is the major cause of overdose death?   barbiturates  
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barbiturates produce excessive drowsiness with an initial response of   euphoria  
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dependence & tolerance develop how with barbiturate use?   rapidly  
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epilepsy is often treated with what type of drug?   barbiturates  
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name six barbiturates   barbital, amobarbital, phenobarbital, pentobarbital, secobarbital, and butabarbital  
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the names of barbiturates all end in   barbital  
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what was the preferred treatment for anxiety in the 1960's?   benzodiazepines  
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which is safer: benzo's or barbiturates?   benzos  
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are benzos addictive   they can be  
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withdrawal of benzodiazepines is similar to withdrawal of   alcohol  
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rapid discontinuation of alcohol and benzos may result in   seizures  
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the symptoms of benzos are different from those of barbiturates how?   benzos are longer acting and less intense  
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which is longer acting: benzos or barbiturates?   benzos  
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which is less harmful in case of overdose? benzos or barbiturates?   benzos  
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GHB is an   illegal CNS depressant  
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GHB is used with   alcohol  
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GHB is considered to be a   designer drug  
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GHB affects are   intoxicating, sedating, euporic  
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GHB has the same effect as what and builds muscle   growth hormone  
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GHB affects heart rate and respirations by   decreasing them  
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What drug is considered to be the forget-me pill?   Rohypnol  
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this drug is a benzo, it's illegal in the US and is used as a date rape drug   Rohypnol  
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the Rohypnol pill is accelerated by   alcohol  
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Rohypnol can be ingested   without knowing  
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why is rohypnol easily given without the victim knowing?   tasteless, odorless, dissolves quickly  
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which is the most widely used and most abused substance?   alcohol  
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any amount of alcohol is considered to be harmful to   fetuses, children, adolescents, recovering alcoholics and those with poor health  
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the ability to metabolize alcohol is predetermined by   genetics  
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alcohol is known chemically as   ehtanol (ETOH)  
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alcohol produces mind and mood   altering effects  
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alcohol content is expressed as   proof  
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in the US proof is how much the ethanol concentration?   twice  
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blood alcohol level measures the degree of   ethanol intoxication  
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the concentration of alcohol depends on what?   the rate of absorption, transportation into CNS, redistribution to other parts of the body, metabolism and elimination  
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alcohol is absorbed through   the mouth, stomach and small intestine  
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what varies depending upon the presence of food, the drinker's emotional state and the drinker's body size?   the rate of absorption  
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does alchohol cross the placenta?   yes  
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alcohol is oxidated in the   liver  
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oxidation in the liver eliminates what percent of the alcohol absorbed by the body?   90  
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does the excretion of alcohol vary or does it take place at a fixed rate?   fixed rate  
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the healthy liver can metabolize how much alcohol in an hour   one ounce  
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alcohol that is not metabolized in the liver   circulates in the blood  
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what type of dependence is developed with alcohol use?   physical and psychological  
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BAC stands for   blood alcohol concentration  
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BAL stands for   blood alcohol level  
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a BAC of 20 is equivilant to a BAL of   0.02  
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effects of a BAL of 0.02   light and moderate drinkers begin to feel some effect  
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at a BAL of 0.04 most people begin to feel   relaxed  
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at what BAL is judgment mildly impaired and the ability to make rationale decisions is declined?   0.06  
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at what BAL is driving impaired, speech slurred, and ataxia and decreased sensory function evident?   0.08  
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at a BAL of 0.10 there is a clear deterioration in   reaction time  
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at what BAL is the person considered to be legally intoxicated in most states?   0.10  
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at 0.15 the BAL there is increased impairment and the alcohol level is equivalent to   a half pint of whiskey in the bloodstream  
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at 0.30 what can happen?   potential cardiovascular and respiratory collapse and loss of consiousness  
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at what BAL is cardiovascular and respiratory collapse a potential complication?   0.30  
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at what BAL is there a potential to lose consciousness?   0.30  
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neurological sydromes resulting from etoh abuse include   wernicke-korsakoff syndrome, marchiafava bignami disease, alcoholic blackouts, mood changes, confusion, hallucinations and peripheral neuropathy  
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wernicke-korsakoff syndrome is inflammatory   degeneration of brain  
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wernicke-korsakoff syndrome effects the brain how   inflammatory degeneration  
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inflammatory degeneration of the brain, as in wernicke-korsakoff syndrome, causes   memory loss and cognitive changes  
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wernicke-korsakoff syndrome is caused by a deficit of what?   thiamine  
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marchiafava bignami disease is   brain atrophy with dysarthria and impaired consiousness  
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alcoholic blackouts cause   anterograde amnesia  
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what drugs are considered to be the foremost gateway drugs?   alcohol, cigarretes and marijuana  
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what ethnicities experience more adverse effects from alcohol use?   chinese, japanese and korean  
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addiction causes a rapid release of neurotransmitters followed by a reduced-from-baseline level that   never fully returns to pre-drug level  
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barbituates, sleeping aids and anti-anxiety medications are all   cns depressants  
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barbituates are the major cause of   overdose deaths  
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what form of alcohol is actually considered to be good for you in moderate amounts?   red wine  
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what health benefits are gained by moderate consumption of red wine?   increased HDL, decreased LDL, decreased diabetic complications and decreased blood sugar levels  
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the standard drink size for spirits is?   one ounce  
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the standard drink size for wine is   five ounces  
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the standard drink size for beer is   twelve ounces  
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breathing can potentially stop at what blood alcohol level?   0.45  
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80% proof is equal to what % alcohol?   40  
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the absorption rate of alcohol   varies  
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the metabolism rate of alcohol is   1 ounce per hour  
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the excretion rate of alcohol is   fixed  
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alcohol is metabolized by the   liver  
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the kansas legal limit for alcohol is   0.08 BAL or 80 BAC  
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alcohol affects thiamine absorption how?   inhibits absorption  
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a decreased level of thiamine may lead to what syndrome?   wernicke-korsakoff  
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wernicke-korsakoff-->brain...   inflammation  
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wernicke-korsakoff-->brain inflammation resulting in   memory loss and cognitive changes  
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if a person that abuses alcohol is suffering from memory loss and cognitive changes, what syndrome may they have?   wernicke-korsakoff  
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wernicke-korsakoff   that's a long name to REMEMBER...memory loss...  
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brain atrophy is associated with   marchiafava bignami  
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brain atrophy...   big nami  
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marchiafava bignami is indicated when the brain is affected how?   brain atrophy  
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what clinical manifestations may result from brain atrophy related to marchiafava bignami   impaired speech and LOC  
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a common clinical manifestation of "march-i-a-fava big-nami" is   impaired speech  
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BP, LDL and Triglycerides are all affected how by etoh abuse?   all increased  
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the risk for what complications r/t bleeding increase with etoh abuse   hemorrhagic stroke  
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alcohol abuse affects Ca & Mag in what way?   decrease  
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the cardiovascular systemic effects of alcohol abuse are   elevates bp, triglycerides, ldl and increases the risk for hemorrhagic stroke, cardiomyopathy  
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what effect does alcohol abuse have on the immune system?   decreased WBC production, increased size of RBC, impaired production of clotting factors and platelets  
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what happens to WBC when alcohol is abused   production is decreased  
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what happens to platelets when alcohol is abused   decreased production  
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what happens to the RBCs when alcohol is abused?   increase in size  
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when RBCs are increased in size what else is changed?   MCV  
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the systemic effects on the liver from etoh abuse include   fatty liver, cirrhosis, varices & ascites  
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accumulation of fats in liver cells leads to   fatty liver  
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chronic hepatic inflammations lead to   cirrhosis  
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what develops as a result of impaired liver circulation   varices & ascites; hepatic encephalopathy  
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alcohol abuse damages the GI tract because of   increased gastric secretions that promote bacterial growth  
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ulcers, gastritis, pancreatitis, esophageal varices are all GI tract disorders potentially caused by   alcohol abuse  
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alcohol abuse impairs the function of the pancrease to   respond to insulin  
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the sleep cycle disturbance caused by etoh abuse is also referred to as   sleep fragmentation  
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how does alcohol decrease calcium & magnesium in the blood?   by reducing parathyroid hormone release  
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the leading cause of birth defects is   etoh consumption during pregnancy  
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hormonal changes due to etoh abuse include changes in prolactin, growth hormone, cortisol and   ACTH  
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what elevated liver enzyme indicates alcohol has been consumed recently?   GGT  
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what is the normal range for GGT   2-30  
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GGT...gin gin tequila   liver enzyme that shows recent etoh use  
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is a ggt level accurate in the 15-30yo age range?   no  
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Large RBCs indicate   anemia  
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what are some lab tests used to determine etoh abuse?   GGT, RBC size, MCV, uric acid, triglycerides, AST, Urea and carbohydrate deficient transferring  
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how long will etoh be present in the urine?   12-24 hours from last drink  
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what is AWS?   alcohol withdrawal syndrome  
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how common is AWS   40% of hospitalized pt have potential to experience it  
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early symptoms of AWS can start within   6-12 hrs after BAC drops  
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symptoms of AWS will peak in   24-48 hours  
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when will AWS symptoms decrease   4-5 days  
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what time frame is a seizure more likely to occur with AWS   7-48 hours after last drink  
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what changes in the HR are seen in AWS?   above 100, tachy  
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seizures can occur within   7-48hrs after last drink  
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AWS peaks   24-48hrs after last drink  
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AWS symptoms decrease   4-5days after last drink  
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is AWS the same as the DTs?   no  
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early etoh w/drawal symptoms include   n/v, anxiety, tremor  
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what type of psychosis do AWS patients experience   visual, auditory or tactile hallucinations  
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what is different about the hallucinations in AWS patients?   the patient knows they aren't real when they are having them  
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alcohol withdrawal delirium is also referred to as   DTs (delirium Tremens)  
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which is the most serious form of alcohol withdrawal?   DTs  
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how common is DT?   occurs in less than 10% of those with AWS  
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what clinical manifestation may characterize impending DT?   disorientation  
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the DTs are often accompanied by   liver failure, pneumonia, and head trauma  
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disorientation is often the first sign of what type of etoh withdrawal?   DTs  
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what assessment tools are used to determine if a patient may have an substance abuse problem?   the CAGE questionnaire, DAST and AUDIT  
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CAGE stands for   Cut down, Annoyed, Guilty and Eye-opener  
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what score on the CAGE questionnaire indicates potential etoh abuse?   2 answers of yes out of the 4 questions  
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the CAGE assessment refers to what type of abuse?   alcohol  
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The DAST is   a brief drug abuse screening tool  
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what DAST score suggests a significant drug abuse problem?   score greater than 6/28  
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what is an AUDIT   alcohol use disorders identification test  
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an AUDIT identifies what type of substance abuse?   drug and etoh  
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if screening tests shows that problems might exist what type of questions with the nurse follow up with?   withdrawal symptoms, tolerance, work history, legal/social complications  
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when eliciting history of substance abuse how should questioning start?   from etoh, nicotine, mj, and then on to cocaine etc  
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along with assessing for a substance abuse problem what else should be assessed?   readiness to change  
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key assessment items include   age of first use, heaviest lifetime use, patterns of use, binges &/or blackouts, last use and family hx, abuse hx and risk for suicide  
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arcus senilis is   an opage grayish ring around the eyes  
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what causes arcus senilis?   alcohol abuse  
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how might the hands be affected by alcohol abuse?   red palms, shaky, cigarette burns, decreased sensation  
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in addition to red palms what else may be red?   face  
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facial redness is known as   acne rosacea  
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an enlarged liver may cause what clinical manifestation?   upper abdominal pain  
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a positive stool _______ may indicate gi bleed   guaiac  
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the hr and bp of an alocholic will be   increased  
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is arcus senilis or cardiac arrhythmia a clinical manifestation of drug abuse?   cardiac arrhythmia  
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a patient presents with conjuctivitis, you suspect what type of substance abuse?   drug abuse  
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how are the eyes affected by drug abuse?   the pupil size changes  
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cardiac arrhythmias, needle tracks, cellulites, conjunctivitis, poor dentition, rapid weight loss and changes in pupil size are indicative of   drug abuse  
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jaundice, arcus senilis, acne rosacea, palmar erthema, upper abdominal pain, cigarett burns on fingers/clothing, decreased sensation in feet hands, positive stool guaiac, HTN & tachycardia and tremor are all indicative of   alcohol abuse  
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what is the most effective pharmaceutical for treating withdrawal and detoxification?   benzos  
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benzo dosing should be   tapered down  
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patients in withdrawal that have liver failure or impaired cognition should be given what type of benzos?   short-acting: Ativan  
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the pt with severe withdrawal will more than likely be taking which type of benzo?   librium, long-acting  
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Ativan is a   short acting benzo  
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ativan is used when   the w/drawal pt has liver or cognition issues  
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librium is   a long acting benzo  
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when is librium prescribed for withdrawal?   when it is severe  
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which is preferred, symptoms-triggered dosing or fixed schedule?   symptoms-triggered dosing  
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what is the concern with fixed schedule dosing?   may over medicate patient  
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what tool is used to assist in symptom triggered dosing?   CIWA scale  
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what is the antidote for benzos?   romazicon (benZo-->romaZicon)  
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what is the antidote for opiates?   narcan  
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if symptoms of withdrawal do not progress in a predictable manner what tool is then used?   CIWA-R  
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the accuracy of the CIWA-R is decreased when the pt has   co-morbidities and psychiatric illnesses  
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how often should CIWA-R be repeated if the patient is actively detoxing   every 1-2 hours  
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if the CIWA-R score is <5   discontinue the CIWA  
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if the CIWA-R scoring is 9 or less what does that indicate?   the absent or mild withdrawal  
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what dosing changes are made if there is a CIWA-R score of 9 or less?   discontinue medications for withdrawal  
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a CIWA score of 10-19 indicates   moderate withdrawal  
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a CIWA score of greater than 20 indicates   severe withdrawal  
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it is important to maintain fluid & electrolyte balance during   withdrawal with delirium  
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history or presence of seizures is vital to asses so that the patient can be   treated with anti-seizure medication  
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what Vitamins are often needed during withdrawal?   B  
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what are the B vitamins needed during withdrawal?   Thiamine, Folic Acid and Vitamin B12  
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besides thiamine, folic acid and vitamin b12 what is also needed   slow mag  
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what treatment is used as an alcohol teterrent by interupting the metabolism of ETOH   antabuse  
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what common ADL items should be avoided when taking antabuse?   aftershave lotion and mouthwashes  
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what common food or bakery ingredients should be avoided in the patient taking antabuse   vanilla extract & vinegar  
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what over the counter medications should be avoided in the pt taking antabuse?   cough-medicines  
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what reaction will a patient have if they drink etoh while taking antabuse   they will become violently ill  
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campral is used to treat what in early sobriety   cravings  
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to prevent relapse for alcoholics that have a "slip"   Revia  
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high-dose withdrawal of cns depressants substitutes medication   from the same drug class for gradual tapering  
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low dose withdrawal depends on   symptoms  
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insomnia, anxiety, elevated temp, pulse and respiratory rate, fine tremors, GI upset, muscle aches, diaphoresis and a labile BP indicate withdrawal from   cns depressants  
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what are the nursing priorities in acute situations of withdrawal?   maintain patent airway, monitor VS, intervene with hemorrhage, seizure and respiratory/cardiac arrest and maintain safety for client and others  
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support during withdrawal process includes   observation, meds, emotional & nutritional  
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the drug abuser still needs pain relief, it is best to   avoid drug of abuse when treating pain  
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in order to avoid relapse we should assist the patient to avoid   being hungry, angry, lonely or tired  
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motivational interviewing focuses on listening rather than   telling  
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gently persuade the patient, understand that   changes is up to the patient  
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fatigue, workaholism, cover-ups, exaggerations, rationalizations, self-pity, victim role, frustration vs appropriate anger, impatience and negativism are all signs of   relapse  
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primary prevention is aimed at   preventing abuse  
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secondary prevention is aimed at   client with mild to moderate problems  
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tertiary prevention is aimed at   decreasing complications of addiction  
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the most important sign of a healthy recovery is when the patient   lets go of toxic people and substances  
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Created by: Lori Dobrisky
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