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322 Old Important

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Term
Definition
absoprtion   show
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show breakdown to smaller particles  
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dissolution   show
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show drug is delivered to tissues; based on blood flow, capillary permeability, protein binding and solubility  
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high distribution   show
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show large, water soluble, bound  
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show liver converts drug into a form that can be excreted; patients with hepatitis or cirrhosis can develop toxicity  
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show kidney removes drugs from the body; if kidney injury leads to drug accumulation  
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show dies out quickly, need more doses  
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first pass effect   show
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show percent of drug ready for use; IV is always 100, oral depends on GI secretion and motor function  
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show liquid since it's already broken down  
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protein binding   show
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show drug toxicity  
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safety in administration   show
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phase 1   show
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show tested in patients with the disease, determine therapeutic effects, safety and effectiveness  
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show clinical market, prescribers observe closely  
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phase 4   show
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show allow air passages to remain open; chosen if patient expericnes side effects from regular bronchodilator  
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short acting inhaler   show
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show salmeterol, prophylactically used for prevention, taken around the clock  
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steroid and bronchodilator   show
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show nervousness, restlessness, BP and HR increase  
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show happens if nasal decongestant is used longer than 3 days  
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show diphenhydramine causes sleepiness and hangover, dry mouth common  
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2nd generation antihistamine   show
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show guaf, must be taken with water  
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expectorant   show
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show hyper osmolar salts pull water into colon and increase water in feces to increase bulk; used in bowel preps; lactulose  
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stimulant laxative   show
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bulk forming laxatives   show
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show stool softener, docusate, used for cardiac patients, give with water  
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show serotonin antagonist; ondansetron for chemo, nausea; no drowsiness side effect; headache, dizziness  
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show use endoscopy tissue sample for H pylori, breath test; double antibiotic therapy and PPI  
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H2 blockers   show
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show suppress secretion of hydrochloric acid and does not allow the body to produce HCl  
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metronidazole   show
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digoxin toxicity   show
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show digoxin immune fab, digibind; excretes through the urine  
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nitroglycerin   show
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side effect nitroglycerin   show
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administration nitroglycerin   show
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show diminish SNS response which lowers BP and HR  
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show relax coronary artery spasm, relax arterioles; peripheral edema, flushing, headache, slows and controls heart rate  
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ace inhibitors - pril   show
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show do not use in renal patients, if potassium is too low, do not administer  
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loop   show
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osmotic   show
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show monitor potassium levels  
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warfarin   show
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warfarin antidote   show
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heparin   show
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show protamine sulfate  
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anticoagulant teaching   show
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adverse reaction of statins   show
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show avoid grapefruit juice, monitor BUN, Cr, liver functions test, have annual eye exams  
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show neuro and safety - side rails padded, lowest position, know timing of seizure, recovery position - side lying  
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show 10 - 20, causes gingival hyperplasia, nystagmus, purple glove syndrome  
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show 4 - 12, hematologic toxicity, GI distress, interaction with grapefruit juice  
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show 40 - 100; blood dycrasias, SJS, lupus, suicidal ideation  
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valproic acid   show
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show lack of dopamine affects the extrapyramidal tract - controls posture, balance, locomotion  
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parkinson care   show
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dopaminergic   show
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myasthenia gravis   show
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show underdosing acetylcholinesterase inhibitors causes generalized muscle weakness and intercostal muscle failure  
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show neostigmine - fast acting AChE inhibitor  
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show overdosing acetylcholinesterase inhibitors, causes respiratory paralysis and arrest within 30 minutes  
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show atropine  
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