322 Old Important
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absoprtion | show 🗑
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show | breakdown to smaller particles
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dissolution | show 🗑
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show | drug is delivered to tissues; based on blood flow, capillary permeability, protein binding and solubility
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high distribution | show 🗑
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show | large, water soluble, bound
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show | liver converts drug into a form that can be excreted; patients with hepatitis or cirrhosis can develop toxicity
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show | kidney removes drugs from the body; if kidney injury leads to drug accumulation
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show | dies out quickly, need more doses
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first pass effect | show 🗑
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show | percent of drug ready for use; IV is always 100, oral depends on GI secretion and motor function
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show | liquid since it's already broken down
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protein binding | show 🗑
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show | drug toxicity
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safety in administration | show 🗑
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phase 1 | show 🗑
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show | tested in patients with the disease, determine therapeutic effects, safety and effectiveness
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show | clinical market, prescribers observe closely
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phase 4 | show 🗑
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show | allow air passages to remain open; chosen if patient expericnes side effects from regular bronchodilator
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short acting inhaler | show 🗑
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show | salmeterol, prophylactically used for prevention, taken around the clock
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steroid and bronchodilator | show 🗑
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show | nervousness, restlessness, BP and HR increase
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show | happens if nasal decongestant is used longer than 3 days
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show | diphenhydramine causes sleepiness and hangover, dry mouth common
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2nd generation antihistamine | show 🗑
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show | guaf, must be taken with water
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expectorant | show 🗑
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show | hyper osmolar salts pull water into colon and increase water in feces to increase bulk; used in bowel preps; lactulose
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stimulant laxative | show 🗑
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bulk forming laxatives | show 🗑
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show | stool softener, docusate, used for cardiac patients, give with water
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show | serotonin antagonist; ondansetron for chemo, nausea; no drowsiness side effect; headache, dizziness
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show | use endoscopy tissue sample for H pylori, breath test; double antibiotic therapy and PPI
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H2 blockers | show 🗑
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show | suppress secretion of hydrochloric acid and does not allow the body to produce HCl
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metronidazole | show 🗑
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digoxin toxicity | show 🗑
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show | digoxin immune fab, digibind; excretes through the urine
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nitroglycerin | show 🗑
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side effect nitroglycerin | show 🗑
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administration nitroglycerin | show 🗑
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show | diminish SNS response which lowers BP and HR
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show | relax coronary artery spasm, relax arterioles; peripheral edema, flushing, headache, slows and controls heart rate
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ace inhibitors - pril | show 🗑
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show | do not use in renal patients, if potassium is too low, do not administer
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loop | show 🗑
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osmotic | show 🗑
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show | monitor potassium levels
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warfarin | show 🗑
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warfarin antidote | show 🗑
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heparin | show 🗑
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show | protamine sulfate
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anticoagulant teaching | show 🗑
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adverse reaction of statins | show 🗑
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show | avoid grapefruit juice, monitor BUN, Cr, liver functions test, have annual eye exams
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show | neuro and safety - side rails padded, lowest position, know timing of seizure, recovery position - side lying
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show | 10 - 20, causes gingival hyperplasia, nystagmus, purple glove syndrome
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show | 4 - 12, hematologic toxicity, GI distress, interaction with grapefruit juice
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show | 40 - 100; blood dycrasias, SJS, lupus, suicidal ideation
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valproic acid | show 🗑
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show | lack of dopamine affects the extrapyramidal tract - controls posture, balance, locomotion
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parkinson care | show 🗑
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dopaminergic | show 🗑
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myasthenia gravis | show 🗑
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show | underdosing acetylcholinesterase inhibitors causes generalized muscle weakness and intercostal muscle failure
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show | neostigmine - fast acting AChE inhibitor
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show | overdosing acetylcholinesterase inhibitors, causes respiratory paralysis and arrest within 30 minutes
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show | atropine
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