Cellular reaction to injury
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show | Adaptation; Cell injury- either reversible (degeneration) or irreversible (death, or necrosis)
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What are 7 major causes of cellular injury? | show 🗑
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What is the most common cause of cellular injury? | show 🗑
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What is Hypoxia? | show 🗑
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show | Trauma; Thermal Injury (extreme heat or cold); Radiation; Electric injury
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show | Therapeutic agents (aspirin); Non-therapeutic agents (alcohol or lead poisoning)
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What are infectious agents that may cause cell injury? | show 🗑
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show | Congenital malformation
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show | Deficiency (avitamoninosis, protein calorie malnutrition); Excess (obesity)
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What are Immunologic reactions that may cause cell injury? | show 🗑
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Whether cell damage is reversible or irreversible is dependent on what four factors? | show 🗑
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What 4 intracellular systems are more vulnerable to cell injury? | show 🗑
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An example of reversible changes are...? | show 🗑
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show | 1. Cloudy appearance of swollen cells due to dispersion of cytoplasmic organelles; 2. Cell membrane shows blunting of microvilli
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show | 1. swelling of endoplasmic reticulum; 2. Swelling of mitochondria 3. Swelling of lysosomes
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What happens with the swelling of endoplasmic reticulum? | show 🗑
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show | Accumulation of fat within parenchymal cells of liver (due to hypoxia, alcohol, or DM); Membrane-bound lysosomes coalesce together producing fatty cysts; Appears as vacuoles due to accumulation of fatty droplets
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What happens when there is irreversible damage of cell membranes? | show 🗑
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show | small dense nucleus
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show | fragmentation
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What is Karyolysis? | show 🗑
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show | Death of group of cells within a living body caused by injurious agent
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show | 1. Nuclear changes- Pyknosis, Karyorrhexis, Karyolysis 2. Cytoplasmic change- Swollen 3. Architectural changes- depend on whether denaturation of proteins or enzymatic digestion prevails
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show | Denaturation of proteins and Enzymatic digestion
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What is denaturation of proteins? | show 🗑
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show | Cell lysis (autolysis, or heterolysis), necrotic tissue appears without structure (liquifactive necrosis)
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What are 7 types of necrosis? | show 🗑
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What is the most common type of Necrosis? | show 🗑
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show | ischemia
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How does coagulative necrosis appear to the N.E.? | show 🗑
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How does coagulative necrosis appear under a microscope? | show 🗑
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show | Cell lysis prevails over protein denaturation; necrotic tissue: soft, liquid-like
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What are some causes of colliquative (liquefactive) necrosis? | show 🗑
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In what kind of necrosis does the necrotic tissue appear white and cheesy? | show 🗑
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What is the cause of Caseous necrosis? | show 🗑
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What are three mechanisms of Caseous necrosis? | show 🗑
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show | Release of pancreatic enzymes into surrounding tissue (ex: traumatic injury, acute pancreatitis)
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show | Fatty acids combine w/ calcium --> calcium soaps: hard chalky white patches, formed of necrotic fat cells, calcification and fibrosis
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show | Trauma (not enzymatic digestion) to fatty tissue e.g. breast, subcutaneous tissue
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show | Release of intracellular fat--> acute inflammation and fibrosis--> firm mass mistaken for breast cancer
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What is fibrinoid necrosis? | show 🗑
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show | 1. malignant HTN--> necrosis of tunica media of arterioles, leakage of plasma protein and deposition of fibrin. 2. Autoimmune diseases: synovial membranes in rheumatoid arthritis (immune complexes, breakdown products of collagen and fibrin)
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What is gangrene? | show 🗑
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What are three types of gangrene? | show 🗑
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Where does dry gangrene occur? | show 🗑
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show | Line of demarcation
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Where does wet gangrene occur? | show 🗑
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show | wet gangrene
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Which type of gangrene has both tissue necrosis and putrefaction which are caused by bacteria? | show 🗑
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show | gas gangrene
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show | gas gangrene
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What is apoptosis? | show 🗑
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What are apoptotic bodies also known as? | show 🗑
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