In each blank, try to type in the
word that is missing. If you've
typed in the correct word, the
blank will turn green.
If your not sure what answer should be entered, press the space bar and the next missing letter will be displayed. When you are all done, you should look back over all your answers and review the ones in red. These ones in red are the ones which you needed help on. Question: Enzymes, are proteins, are usually responsible for?Answer: The biotransformation of Question: does the vast majority of drug metabolism take place?Answer: in the Question: What is the most important group of enzymes for drug ?Answer: cytochrome P450 Question: Biotransformation metabolizes active drug to one of things. What are the three things the drug could be metabolized to?Answer: Less compound, Inactive compound, or Another active compound. Question: What is a ?Answer: a medication that is inactive when administered, but is quickly metabolized to an active form. Question: What are two of prodrugs?Answer: Cortisone and Question: What is the -pass effect?Answer: a phenomenon of drug whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation. Question: Clearance of a medication to?Answer: the volume of blood that is completely cleared of the drug per unit Question: Renal elimination/excretion one or more of three processes....what are they?Answer: , Active secretion, and reabsorption Question: The passage of active, unchanged drug from the blood stream through the glomerulus into the urine is ?Answer: Question: The secretion of active, unchanged drug into the (and eventually into the urine) is called?Answer: secretion Question: The of the drug returning to the blood stream before reaching the urine is known as what?Answer: Question: What is Half-life?Answer: the amount of time it takes for the plasma concentration or the amount of a drug in the body (after and distribution) to be reduced by 50 percent. Question: What is half-life upon?Answer: clearance Question: How would a decrease in clearance affect the half-life of a drug, and how will that the drug concentration in the blood?Answer: It will the half-life, drug concentration will be increased as well. Question: A decrease in clearance and an in half-life could lead to what?Answer: toxicity (in some ) Question: When does a drug steady state?Answer: when the of drug being administered equals the amount being eliminated. Question: In general how many half lives does it take for a drug to reach state?Answer: Question: In general, medications with a long half-life will have a interval of what?Answer: once per Question: In general, medications with a shorter half-life will have a interval of what?Answer: twice per day or to four times per day Question: What is the of pharmakokinetics?Answer: the effects of the body on Question: What are the four of pharmakokinetics?Answer: , distribution, metabolism, and excretion Question: What is ?Answer: the amount - stated as a - of a drug that reaches the systemic circulation after extra-vascular administration. Question: What the bioavailability of an IV drug be?Answer: 100% (all of the drug reaches circulation) Question: Which will have an on the bioavailability of a drug, reduced rate of absorption or reduced extent of absorption?Answer: reduced of absorption Question: Drugs "exist" in one of two "forms" they are in the body....what are they?Answer: free(unbound,not protein bound) or protein Question: Drugs must be in which form to be active and have a effect?Answer: free(unbound) Question: What is the protein that drugs may bind to and where is it made?Answer: albumin, in the |
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txst spr 2009
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