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Ch.30 Migraine Drugs
Pharmacology for Nurses
Question | Answer |
---|---|
Drugs for Migraines | Migraines are though to be caused by intracranial blood vessel dilation and inflammation and is associated with nausea, vomiting, photophobia, and phonophobia |
Drugs for Migraines | Triggers for migraines: emotions, food, caffeine, weather |
Ergotamine (Ergostat) | drug commonly coupled with caffeine to enhance vasoconstriction and absorption |
Ergotamine (Ergostat): Drug Interactions | Should not be used to triptans (sumatriptan, zolmitriptain) due to prolonged vessel effects |
Ergotamine (Ergostat): Drug Interactions | Watch for interaction with other CYP450 inhibitors because it can cause toxic dose of ergotamine |
Serotonin Receptor Agonists: Saumatriptan (Imitrex) | Is considered the BEST drug for migraine attacks |
Serotonin Receptor Agonists: Saumatriptan (Imitrex): Drug interactions | Avoid use with ergotamine and MAOIs in the last 224 hours |
Migraine Preventive Therapy: Beta Blockers: Propranolol (Inderal) | Used most often to prevent migraines |
Migraine Preventive Therapy: Beta Blockers: Propranolol (Inderal) | Used to decrease number and intensity of migraines |