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Ch.80 Other GI Drugs
Pharmacology for Nurses
Question | Answer |
---|---|
Antiemetic: Emetic response is caused by activation of the ___center in the ___ oblongata. | vomiting; medulla |
Antiemetic: drugs act on ___ to produce the anti-emetic effect | receptor |
Serotonin Receptor Anatagonist: | Ondansetron (Zofran) |
Ondansetron (Zofran): highly effective in treating-chemo-induced nausea ____; ____ and vomiting caused by radiation and anethesia | vomiting; nausea |
Ondansetron (Zofran): more effective when combined with _____ | dexamethasone |
Ondansetron (Zofran): side effects include _____, diarrhea, and ____ | headache; dizziness |
Ondansetron (Zofran): can be given ___ or IV | PO |
Dopamine Antagonists: | Prochlorperazine (Compazine) |
Dopamine Antagonists: Prochlorperazine (Compazine): used for emesis induced by surgery, chemo, and ____ | toxins |
Dopamine Antagonists: Prochlorperazine (Compazine): side effects include anticholinergic effect, hypertension, and ____ | sedation |
Dopamine Antagonists: Methoclopramide (Reglan): used for ____ nausea and vomiting; nausea and vomiting caused by chemo, opioids, toxins, and radiations | postop |
Cannabinoids: Dronabinol (Marinol) {last resort drug} | Dronabinol (Marinol) {last resort drug} |
Cannabinoids: Dronabinol (Marinol): used to suppress CINV and for stimulating appetite in patients with ____ | AIDS |
Cannabinoids: Dronabinol (Marinol): watch for dysphoria, CNS effects, tachycardia, hypotension, and _____ | drowiness |
Cannabinoids: Dronabinol (Marinol): Do not combine with other ___ depressants | CNS |
Other anti-emetic considerations: Glucocorticoids, benesodiazepines, and neurokinin antagonists are also use to treat ____ | Nausea and vomiting |
Motion Sickness: Scopolamine (Transderm Scop-patch): muscarinic antagonist and treats/ prevents motion sickness by acting on vestibular apparatus of ______; side effects include dry mouth, blurred vision , drowiness | inner ear |
Motion Sickness: Dimenhydrinate (Dramamine)& meclizine (Antivert): antihistamines that affect the _______ pathway to the vomiting center; side effects are ____, dry mouth, blurred vision, urinary retention, and _____ | inner ear; sedation; constipation |
Anti-diarrheal agents: watch for ___ and ___ depletion in these patients; identify the underlying ___ of the diarrhea and treat that first | dehydration; electrolytes; disease |
Non-Specific Anti-Diarrheal Agents: Opioid-> Diphenoxylate(lomotil): Activates ___receptors in GI tract and ____intestinal transit; causes increased absorption of ___ and ___; is given with ___ to discourage abuse, yet euphoria can occur at high doses | opioids; slows; fluid; nutrients; atropine |
Opioids-> Loperamide (Imodium): used to ____ discharge in ileostomies; given in capsule form and does not cross the BBB | reduce |