Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
leukemia
| Question | Answer |
|---|---|
| What is leukemia | A cancer that originates in the bone marrow from a single cell and multiples affecting healthy blood cells |
| How does acute and chronic differ? | Acute are undifferentiated immature blast cells and have a short survival time and chronic mature nonfunctional cells with longer survival rate |
| What is the difference between myeloid and lymphoid cells? | Myeliod turn into functional RBCs, PLTs, WBCs and lymphoids make t-cells or b-cells |
| What genetic factors are associated w leukemia? | trisomy 21 (downs) and kliefelter's syndrome (XXY) |
| What other factors are associated w leukemia? | virus (Epstein Bar, HIV), radiation, Drugs (chemo), chemicals (solvents, benzenes) |
| What labs are associated w leukemia? | anemia (>4.5), neutropenia (>1,700), thromobocytopenia (>150,000), hyperuricemia (<6.8), increased LDH (<115) |
| How is a cytogenic analysis taken? | through bone marrow |
| What are S/S of neutropenia? | fever, abd pain, resp infection, perrectal abscess, mucositis, adenopathy |
| What are S/S of thrombocytopenia? | petchiae, purpura, bleeding, gums, epitaxis, retinal hemorrhage, intracranial bleed |
| What are S/S of anemia? | Pallor, dyspnea, fatigue, maliaise |
| What are S/S of leukemia infiltrates? | HA, splenomeagaly, hepatomeagaly, pain and swelling in joints, lyphadenopathy |
| What are the primary goals of treatment? | hematopoesis, eliminate residula dz, treat extramedullary sites, suppress resistant clones |
| What are the options for systemic treatment? | chemo, target, and immunotherpay |
| How does acute treatment start and end? | Starts with remission induction chemo and ends with post-remission consolidation |
| What leukemia uses CNS prophylaxis via intrathecal? | ALL |
| Which leukemia uses stem cell transplant? | AML, CLL |
| Which leukemmia does a watchful waiting? | CLL |
| Which leukemia uses target therapy indefinitely? | CML |
| Which leukemia has auer rods? | AML |
| What factors make a PT more at risk for a poor prognosis? | previous chemo or radiation, <70, WBC<100,000, previous blood disorder, infection, M5, or poor cytogenetics |
| What is the goal for AML? | Bone marrow supression |
| When is a bone marrow aspiration done? | day 14 |
| What determines if "remission?" | <5% |
| When is a bone marrow aspiration repeated? | 3-4 weeks post induction |
| What is used during relapse of AML? | Gemtuzumab ozogamicin (Mylotarg) |
| What is distinct of Leukemia M3? | contains promyelocytes, 40% in DIC |
| What made Leukemia M3 have a much better prognosis? | all-transretinoic acid (ATRA) |
| How many consolidation cycles does APL have to go through? | 2 |
| What are the three stages for CML? | chronic, accelerated and blast crisis |
| What are the S/S of chronic phase? | pallor, night sweats, fatigue, dyspnea, anemia, anorexia, wt loss, sternal tenderness, fullness, abd distension |
| What are the S/S of accelerated phase? | chronic S/S + fever, hepatomeagaly, hypermetabolism, splenomegaly, lymphadenopathy |
| What is the survival rate expectancy of accelerated phase? | one year |
| What are the nursing priorities for a neutropenic pt? | watch for fever, ATB, ATF, cultures, CXR |
| what nincreases the risk of leukocytosis? | WBCs <50,000 |
| What are the consequences of hyperurecimia? | gout like symptoms, renal obstruction, kidney failure |
| What are the treatments for hyperuricemia? | allopurinol, hydration, and alkalization of urine |
| Where to most lymphomas arise from? | b-cells |
| What type of cells do Hodgkins lymphoma have? | Reed-sternberg cells |
| What grade is Burkitts? | high grade, agressive |
| Which is more common? NHL or HL? | NHL |
| What are the risk factors of HL? | Epstein Bar, HIV, Mono, same sex siblings |
| What are the risk factors for NHL? | hair dying, asbestos, rubber production, radiation, EBV, H.pylori |
| Where do lymphadenopathies occur in HL? | cervical, subclavicular, and medistinal |
| Where to lymphadenopathies occur in NHL? | Extranodule |
| Watchful waiting is associated with which, NHL? or HL? | NHL |
Created by:
brebre273
Popular Nursing sets