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Three phases of drug action for PO Drugs
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Pharmaceutic Phase
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Pharmacy
A Nursing Process Approach Chapter 1
| Term | Definition |
|---|---|
| Three phases of drug action for PO Drugs | Pharmaceutic (dissolution), Pharmacokinetic, and Pharmacodynamic |
| Pharmaceutic Phase | (Dissolution) is the first phase of drug action, has two phases known as disintegration and dissolution. |
| Disintegration | the break down of a tablet into smaller particles |
| Dissolution | the dissolving of the smaller particles in the GI Fluid before absorption. |
| Rate Limiting | is the time it takes a particular drug to disintegrate and dissolve to become available for the body to absorb it. |
| Excipients | Fillers used in tablets to allow for stability of drug or shaping of tablets. |
| Pharmacokinetics Phase | is the process of drug movement to achieve drug action. Consists of 4 processes; absorption, distribution, metabolism, and excretion. This is the second phase in PO medications and the initial phase in parenteral drugs. |
| Absorption | is the movement of drug particles from the GI tract to body fluids by passive absorption, active absorption, or pinocytosis. |
| First-Pass Effect | Hepatic First Pass: metabolism by the liver from the hepatic portal vein after absorption from the lumen of the intestines. |
| Bioavailability | is a subcategory of absorption. It is the percentage of the administered drug dose that reaches the systemic circulation. |
Created by:
aaron.streeter2
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