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SLE
Question | Answer |
---|---|
What are the different forms of lupus? | SLE, Discoid lupus erythematosus, and drug induced lupus |
What genetically triggers lupus? | TREX1 gene mutation |
Who is most effected by Lupus? | non-white women during childbearing years |
What is the most common infection in lupus pts? | pneumonia |
How is the disease spectrum of lupus? | mild-rashes,arthritis, fatigue moderate-pericarditis, low blood count, severe-renal failure, seizures |
What are the disease specific tests for lupus? | positive anti-Smith, positive anti-double strand, positive anti-phospolipid antibody, false-positive syphilis, RPR, ENA IgG Beadchip test (can detect 6 autoantibodies), Anit RO, Anti LA |
Why is it important to know if the pt is anti-phospolipid antibody positive? | cause these pts are more likely to form clots and need to be on anticoagulant therapy |
What is the mnemonic associated w lupus? | SOAP BRAIN MD Serositis, Oral ulcers, Arthritis, Photo-sensitivity, Blood disorder, Renal disorder, Antinuclar antibodies, Immunological disorder, Neurological disorder, Malar rash, Discoid rash |
What is the med used for advanced kidney damage in lupus patients? | cellcept |
What is prasterone? | it is a male hormone used to counteract the amount of estrogen |
What type of meds are paquenil and aralen? | anti-malarial drugs, used after cortecosteriods are no longer working |
What does Belimumab do? | decrease b cell production |
How does Rituximab work? | kills B cells |
How does infliximab work? | binds inflammation signals |
What other diseases does lupus put you at risk for? | leukemia, lymphoma, breast CA, heart dz |