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Which ratio of anticoagulant to blood is acceptable for coagulation procedures
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Platelet aggregation is dependent on the presence of
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Coagulation final
| Question | Answer |
|---|---|
| Which ratio of anticoagulant to blood is acceptable for coagulation procedures | 9:1 |
| Platelet aggregation is dependent on the presence of | EPI (epinephrine, collagen, and calcium) |
| The vasoconstrictor substance released from the platelets at the site of injury is | thromboxane A2 |
| Which organ is responsible for sheltering 20% of the platelet volume in the circulation? | spleen |
| The main substrate of the coagulation system is | fibrinogen |
| A decreased platelet count is most often anticipated when a patient demonstrates | bleeding mucous membranes, gingival bleeding, existaxis purpura, and petechiae |
| which of the following is a component of the fibrinolytic system | plasminogen, plasminogen activators, plasmin, fibrin, fibrin degradation products and inhibotors of plasminogen and plasmin, urokinase |
| which of the following is NOT a component of the fibrinolytic system | thrombin |
| The prothrombin group consists of factors | II, VII, IX, X |
| Anticoagulant, monitored by activated partial thrombin time (aPTT) or anti-factor Xa assay and inactivates thrombin | Heparin |
| Which factor is involved in contact activation | fitzgerald factor also known as High-Molecular-weight-kininogen (HMWK) |
| Which factor is measured by both PT and aPTT | factor I, II, V, X |
| Which protein is not made in the liver | Von Willebrand |
| In the prothrombin test, the patient's citrated plasma is combined with | thromboplastin and CaCl (calcium chloride) |
| Which of the following causes irreversible inactivation of platelets | asprin |
| The autoantibody generated in ITP (idiopatic thrombotic purpura) is directed against | sites on a glycoprotein GPIIb-IIIa or GPIb-IX |
| Which of the following are platelet adhesion disorders | VonWillebrands(vWD), Benard-Soulier, Glanzman's Thrombasthenia |
| Decompression acetate (DDAVP) is an effective treatment for vWD because | the release of endothelial vWF and may be given and injectable agent or nasal spray, portable and convenient |
| In thrombotic thrombocytopenia purpura, which of the following statements are most accurate | deficiency of ADAMTS-13, a large metalloprotease responsible for cleaving large von willebrand factor into small proteins |
| The presence of thrombocytopenia and giant platelets in a patient's plasma is characteristic of | Bernard-Soulier Syndrome |
| Which of the following conditions may result in thrombocytosis | Primarily seen in Myeloproliferative disorders (Platelets are increased with impaired function |
| In hemolyic uremic syndrome(HUS), which of the following statements is the most accurate | the toxin responsible Eschericha Coli 0157:H7 or shiga; mimics TTP |
| Platelet aggregation cannot occur if ______ is absent | GPIIb/IIIa, fibrinogen, or calcium |
| The anticoagulant of choice for routine coagulation procedure is | sodium citrate |
| The process of fibrin degradation is called ____ and is controlled by the enzyme _____. | Fibrinolysis, plasmin |
| A prolonged thrombin and a normal repilase time is indicative of | heparin therapy |
| All of the following are functions of thrombin except | activating thromboplasmin |
| D-dimers may be elevated in which of the following | Deep vein thrombosis (DVT) |
| A primary inhibitor of the fibrinolytic system is | alpha-2 antiplasmin |
| Normal results of a thrombin time is | 10-15 sec |
| Which are the byproducts of fibrinolysis | FDPs (Fibrin degradation products) and D-dimers |
| Which of the following hematology disorders will likely trigger an episode of DIC | APL, AML, microangiopathic orders, thrombotic thrombocytopenia Purpura (TTP) |
| The D-dimer test measures | breakdown of fibrin |
| Obstetrical complications like retained placenta or abruption placenta are a leading cause of | DIC (desseminated Intravascular Coagulation) |
| The international normalized ratio (INR) is useful in | Warfin (coumadin) monitoring |
| All of the following statements are true of coumadin | inhibits vitamin K; vitamin K dependent factors II, VII, IX, X; 36 hr half-life |
| The lupus anticoagulant is directed against | phospholipid binding proteins |
| Heparin induced thrombocytopenia (HIT) usually occurs | 5-14 days after heparin therapy |
| Factor 8 inhibitors | Thrombin - platelet phospholipid, develops in 15-20% of all individuals with hemophilia, autoantibodies against factor VIII - TIME AND TEMP DEPENDENT,capable of neutralizing the coagulant portion of factor VIII |
| What therapy may be used for a hemophiliac who is bleeding but has a low titter factor VIII inhibitor | high dose of factor 8 consintrait |
| Which of the following is the most prevalent inherited bleeding disorder | von Willebrand |
| A prolonged aPTT is corrected with factor VIII-deficient plasma but not with factor IX deficient plasma. What factor is deficient? | IX |
| Factor assays measure percent activity of a given factor mixing the patients plasma with | factor deficient plasma |
| Which platelet responses are most likely associated with hemophilla A | platelets work fine, decrease clotting factors VIII and IX |
| Long term antibiotic therapy is a cause for bleeding because it disrupts | disrupts intestinal flora which disrupts vitamin K synthysis |
| Which of the following is the most useful in differentiation hemophillia A and Hemophillia B | factor assays VIII (A) and IX (B) |
| The treatment of choice for hemophillia A individual is | recombinant factor products - factor VIII consintrait |
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