Save
Busy. Please wait.
Log in with Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Immunodeficiency

Patho

QuestionAnswer
abnormality in one or more branches of the immune system and renders the person susceptible to disease normally prevented immunodeficiency disorders
what are the 2 classifications of immunodeficiency disorders? primary: congenital or inherited (most are x-linked) and secondary: more common
what are the 4 immunodef disorders that are a result of a deficiency in humoral immunity as a result of selective loss of immunoglobulin thru the GI or GU x-linked agammaglobulinemia, common variable immunodef, selective immunoglobulin A def, immunoglobulin G subclass def
any disease that prevents the B cell maturation of stem cells in infants. this leads to recurrent respiratory and ear infections, resolves by 2-4 years of age, > r/f strep, haemophilus influenzea, staph, and pseudomonas immunodef disorders that are a result of a deficiency in humoral immunity
recessive trait affecting only males and they essentially no immunogloublins...they are susceptible to everything from staph to meningitis, but T cells are normal x-linked agammaglobulinemia
s/s of x-linked agammaglobulinemia being around months when the mother's immunity has run out
a clue of ______ is that infections do not respond well to ABT x-linked agammaglobulinemia
what is god to look at to test for x-linked agammaglobulinemia? look at immunoglobulin levels
what is the TX for x-linked agammaglobulinemia? immunoglobulin infusions and early ABT
what are some complications ofx-linked agammaglobulinemia? early pulmonary disease
differentiation of B cells in to plasma is blocked-probably in utero and usually also have problems with t cells common variable immunodef
complete absence of IgG and IgA production, an > rate of spontaneous apoptosis, impaired DNA repair, and has the presence somatic mutations affecting B cells regulation common varibale immunodef
what are the s/s of common variable immunodef disorder? similar to x-linked agamma. s/s, but appears later like 15-35 years of age....equal with genders...>r/f chronic lung dx, hepatitis, gastric carcinoma, & chronic diarrhea w/ malabsorption
what is the treatment for common variable immunodef disorder? similar to x-linked agamma (immunogloblin infusions and early ABT
most common immunoglobulin definiceny selective immunoglobulin A deficiency
reduction in levels of serum and secretory IgA r/t a block in the pathwy of B cells differenetation into IgA selective immunoglobulin A deficiency
most are usually asymptomatic r/t IgM and IgG compensate and half of the cases reslove before age 14 selective immunoglobulin A deficiency
what are the s/s for selective immunoglobulin A deficiency? repiratory and GI infections, allergies, asthma
there is no tx for ______ selective immunoglobulin A deficiency
can develop antibodies against IgA that can lead to anaphylaxis w/ the adm of blood componets that contain IgA selective immunoglobulin A deficiency
is a deficiency in any of the 4 subclasses of IgG Immunoglobulin G Subclass deficiency
B cells _____ immunity humoral
T cells ______immunity cell-mediated
what are the 4 subclasses of the immunoglobulin G deficiency? B cells, T cells, phagocytes, and complement
what is the treatment for Immunoglobulin G Subclass deficiency? ABT may be used to prevent infection, IV immunoglobulins and polysaccharide vaccines conjugated to protein carriers
rare immunodef. disorders that have a low survival rate T cell deficiency
what is the cause of the T cell def? (3) defect in the expression of t cells, cytokinin production, and t cell activation
What are 2 of the T cell def immunodef disorders? DiGeorge Syndrome and -linked immunidef with hyper IgM
Caused by a large deletion from chromosome 22, produced by an error in recombination at meiosis DiGeorge Syndrome
Defect occurring before the 12th week gestation when the thymus, parathyroid, and parts of the head, neck and heart are developing DiGeorge Syndrome
Caused by teratogens and affects both genders DiGeorge Syndrome
What are the S/S of the DiGeorge Syndrome? cleft palate, autism, learning disabilities, heart defects, recurrent infections
Commonly see hypercalcemia and tetany within 24 hours r/t an absent parathyroid and will have recurrent infections DiGeroge Syndrome
what is the TX for DiGeroge Syndrome? Tx-thymus and bone marrow transplantation
Low IgG and IgA with normal or high levels of IgM X-linked immunodef with hyper Igm
Inability of the T cells to signal B cells to switch to IgG and IgA, leaving IgM and is in MALES ONLY X-linked immunodef. with Hyper IgM
What are the S/S of X-linked immunodef. with Hyper IgM? appear 1-2 years of age including pyrogenic infections, increased r/f Pneumocystis carinii infections, hemolytic anemia, thrombocytopenia, neutropenia, and increased occurrence of other autoimmune disorders
The Combined Immunodef disorder is _______ and affects all aspects of the ______ function. life-threatening and immune
requires bone transplants and may be mild to fatal combined
Combined immunodeficiency syndromes and a variety of inherited conditions and Disruption of the T and B cell system and deregulation of the immune response combined
In a severe combined immunodef there is an absence of ALL ______ finctions and 50% of cases have _____ immune...fam history
Both autosomal and X linked andAppears like AIDS in infants w/ chronic diarrhea and opportunistic infections usually leading to death by 2 severe combined immunodef
If caught before 3 months of age, can be treated with human leukocyte antigens or T cell depleted bone marrow stem cell transplants severe combined immunodef
50% of cases have a decrease in adenosine deaminase leading to toxic metabolite accumulation severe combined immunodef
Enzyme replacement in conjunction with usually tx may help severe combined immunodef
Created by: TayBay15
Popular Nursing sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards