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Bleeding Disorders
Patho
| Question | Answer |
|---|---|
| PLT<100,000 | Thrombocytopenia |
| what are the causes of Thrombocytopenia? | Causes-decreased production, increased plt pooling in spleen, or deceased plt survival |
| autoimmune; Plt antibodies form increasing destruction | Idiopathic Thrombocytopenia Purpura (ITP) |
| Which type of Idiopathic Thrombocytopenia Purpura (ITP) is more common in children and is r/t a viral infection with NO TX? | Acute |
| Idiopathic Thrombocytopenia Purpura (ITP) that is more common in adults and women and is associated with AIDS and SLE | Chronic |
| What are the TX for Idiopathic Thrombocytopenia Purpura (ITP)? | TX-corticosteriods, splenectomy, and immunosuppressants |
| What are the S/S of Thrombotic Thrombocytopenic Purpura (TTP)? | S/S-purpura, petechiae, HA, seizures, and altered consciousness |
| What is the TX forThrombotic Thrombocytopenic Purpura (TTP)? | TX-plasmapheresis |
| What is the common trigger ofThrombotic Thrombocytopenic Purpura (TTP)? | E. coli |
| Combination of thrombocytopenia, hemolytic anemia, vascular occlusion (capillary thrombi of organs), fever, and neurological abnormalities | Thrombotic Thrombocytopenic Purpura (TTP) |
| What are some causes of coagualtion defects? (5) | liver disease, Vit k def, Hemophilia A and B, and Von Wilebrand disease |
| deficiency of factor VIII; X-linked | Hemophilia A |
| What are S/S of Hemophilia A? | S/S-bleeding of soft tissue, GI tract, and hip, knee, elbow, and ankle, jt bleeding that leads to inflammation |
| What is the TX for hemophilia A? | TX-Factor VIII replacement, recombinant factor VIII, and desmopression acetate |
| most common hereditary bleeding disorder | Von Willebrand Disease |
| < PLT adhesion and reduction of factor VIII; autosomal | Von Willebrand Disease |
| What are the S/S of Von Willebrand Disease? | S/S-bleeding form nose, mouth, & GI tract |
| What is the TX for Von Willebrand Disease? | Severe case tx-replacement of clotting factors, desmopressin acetate, but most are mild and untreated |
| paradox in hemostatic sequnece | Disseminated Intravascular Coagulation (DIC) |
| Widespread intravascular coagulation followed by massive bleeding d/t the depletion of clotting factors | Disseminated Intravascular Coagulation (DIC) |
| bleeding from small vessels d/t structurally weak walls, damage d/t inflammation or immune response | vascular disorders |
| What are the S/S of Disseminated Intravascular Coagulation (DIC)? | TX-tx cause, replacing clotting components, and preventing activation of clotting mechanisms; fresh-frozen plasma, plts, cryoprecipitate, and Heparin |
| What are some EX of vascular disorders? | Ex-hemorrhagic telangiectasia, Vit C deficiency, Cushing’s disease, and senile purpura |
| What are the S/S of vascular disorders? | S/S-easy bruising, spontaneous petechiae and purpura, but PLT counts and bleeding studies will be normal |
| Why does chronic stress lead to heart attacks? | b/c of hte chronic inflammation that damages the lining of the vessels |
Created by:
TayBay15
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