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Stack #158845
kilgore lvl1: adrenergic agonists
| Question | Answer |
|---|---|
| a1 on pupilary muscle of iris | Mydriasis (dilation of pupil) |
| a1 on blood vessels fo skin, viscera | vasoconstriction |
| a1 on GI sphincters | constriction (less GI motility) |
| a1 on bladder sphincter | constriction (less urination) |
| a2 on presynaptic nerve terminals | inhibition of neurotransmitter release (less SNS-type reactions, & more PSNS-type reactions) |
| B1 on Heart | increased rate, force of contraction & AV conduction (increased inotropic, chronotrophic and dromotrophic effects) |
| B1 on Pancreas | Decreased insulin release (causes blood sugar to rise/stay high for maximum energy supply) |
| B2 on Blood vessels of heart, lung & skeletal muscle | vasodilation |
| B2 on liver | glycogenolysis (glycogen reduced into glucose for use by muscle tissues) |
| B2 on kidney | increased renin secretion (causes rise in B/P by triggering the renin-angeiotensinII-aldosterone pathway) |
| B2 on GI muscle | Decreased motility (seriously, do you want to have to poop when fighting or fleeing for your life?) |
| B2 on Uterus | relaxation (again, you don't want to be going thru labor pains if you are fighting or fleeing) |
| B2 on Bronchial muscles | dilation (need to breathe well) |
| Dopamine on Kidney | dilation of kidney vasculature (decreased pressure on the glomerulus, so since less fluid is going thru nephron, less fluid is being excreted as urine, so B/P rises/stays higher |
| which drugs are Bronchodilators | ->Albuterol ->EP ->sammeterol (Serevent) formoterol (Foradil) isoetharine (Arm-a-med) levalbuterol (xopenex) terbutaline |
| What are B2-agonist drugs called | Bronchodilators because they are selective to the lungs |
| key facts of albuterol | Bronchodilator (specific B2-agonist) -increased glycogenolysis and renin secretion -vital signs s/b taken frequently |
| key facts on EP (epinephrine) | non-specific, but works well for bronchodilation & as a vasoactive drug -high doses causes vasoconstriction -low doses affect primarily B1 receptors and are +inotrophic and +chronotrophic |
| key facts on salmeterol | Bronchodilator specific to B2 -prevention of acute asthma, NOT for an asthma attack |
| Which drug is a mixed-adrenergic nasal decongestant? | Pseudoephedrine stimulates both a & B receptors to shrink nasal mucosa & reduce nasal secretions -> possible rebound effect when using nasal inhalants |
| What are vasoactive adrenergics | adrenergics that have primarily cardioselective effects. ->Cardioselective effects stem from mainly B1-stimulation |
| Which drugs are vasoactive adrenergics? | ->dobutamine (Dobutrex) ->dopamine (Intropin) ->EP ->NE fenoldopam (Corlopam) midodrine (ProAmatine) phenylephrine (Neo-Synephrine) |
| Key facts on dobutamine | B1-selective increase cardiac output & stroke volume via positive inotropic effect |
| key facts on dopamine | stimulates B1 and a1-receptors low doses dilate central blood vessels higher doses have +inotropic effects and increase cardiac output **DO NOT use if pheochromocytoma is diagnosed** |
| key facts on NE (norepinephrine) | primarily stimulates a1-receptors -vasoconstricts some B1 stimulation, but NO B2 stimulation -used mainly for hypertension and shock |
Created by:
gfcfnina
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