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Pharm Unit 17
SPC Pharmacology Unit 17 Exam 6
Question | Answer |
---|---|
Somatic Nervous System deals with what? | Skeletal System |
What receptors deals with the Somatic Nervous System? | Nicotinic II Receptors |
How many receptors are in the Somatic Nervous System? | 1 Nicotinic II Receptor |
What is the single neurotransmitter with Somatic Nervous System? | Acetylcholine (Ach) |
What does Acetylcholinesterase do? | Terminates Neurotransmitter (Ach) and allows repolarization |
What terminates Acetylcholine? | Acetylcholinesterase |
Peripheral Acting Drugs are administered through.... | IV (Intravenous) |
T/F Peripheral Acting Drugs are Dose Dependent? | True |
Peripheral Acting Drugs does what? | Interferes with N2 receptors at the muscle |
What are the two types of Neuromuscular Blockers? | Non-depolarizing & Depolarizing |
Which type of Neuromuscular Blocker can be reversed with an antidote? | Non-depolarizing Blocker |
Which type of Neuromuscular Blocker can NOT be reversed with an antidote? | Depolarizing Blocker |
How is both Depolarizing and Non-Depolarizing administered? | Injection or IV |
Onset of Non-depolarizing N/M Blocker? | 3-5min |
Duration of Non-Depolarizing N/M Blocker? | 20-30min |
T/F Non-depolarization is an antagonist? | True |
What does Depolarizing Neuromuscular Blockers do? | Stimulates N2 receptor then blocks it |
Non-Depolarizing Neuromuscular Blockers can cause..... | Malignant hyperthermia/Spike Potassium levels/Fasciculations |
T/F Depolarizing is fast acting? | True |
T/F Non-Depolarizing is fast acting? | False |
Depolarizing Neuromuscular Blockers can cause..... | Contractions then N2 receptor is blocked |
ALWAYS give what with paralytics? | Analgesics (pain meds) & Sedatives |
T/F Analgesics and Sedations should be given with paralytics? | True |
"ALWAYS REMEMBER" Patients with paralytics can still what? | Hear, Feel, & Smell when paralyzed |
What CANT patients do when paralyzed? | Move or Speak |
Without Analgesics.... | Pain is present |
Without Sedations.... | Stress & Fear is present |
T/F Keep eyes moist under a paralytic? | True |
What is the antidote for Non-depolarizing Neuromuscular Blockers? | Prostigmine (Neostigmine) |
Train of Four is used.... | To asses the degree of paralysis |
What is the process of Train of Four? (2 Step Process) | (Step 1) A small electrical device gives a micro-electrical shock to the hand. (Step 2) Count the # of twitches EX. 4 twitches= <75% block & 3 twitches= 90% block & 2 twitches= 95% block & 1 twitch= 98% block |
What is significant to remember with use of Train of Four. | The patient should be reversed to have some movement every 24hrs to reduce possible long term complications. |
What does anticholinesterase promote? | Skeletal Muscle Contractions |
Anticholinesterase medications potentiates what? | Ach at N2 receptor by inhibition of acetylcholinesterase |
What medication is used to diagnose (Dx) Myasthenia Gravis? | Tensilon |
If a patient has Myasthenia Gravis how would you know? | Quick onset and ultra short acting but the patient will get stronger. |
What are the 2 medications for maintenance of Myasthenia Gravis? | Eserine (Physostigmine) & Mestinon (Pyridostigmine) |
Eserine and Mestinon are both what type of medications? | Maintenance drugs for MG (Myasthenia Gravis) |
Incorrect Dosing drugs for Myasthenia Gravis causes what? | Under dose is "Myasthenia Crisis & Overdose is "Cholinergic Crisis both of which the patient becomes weaker. |
What are two types of Non-Depolarizing Medications? | Norcuron & Zemuron |
What are the anitdotes for Norcuron and Zemuron? | Edrophonium, & Prostigmine (Neostigmine) |
Norcuron is also known as what? | Vercuronium |
Zemuron is also known as what? | Rocuronium |
What is best known for Norcuron and Zemuron as Non-Depolarizing NM Blockers? | They are known to have few or low incidence of adverse cardiovascular effects |