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Pharm Test 3
Term | Definition |
---|---|
Enalapril | Vasotec Ace Inhibitor |
Enalapril Indications | HTN HF |
Enalapril Interactions | Other HTN meds = additive Thiazide = increase K loss Increase lithium toxicity NSAIDs= decrease effects = Increase BP |
Enalapril CI | Hypersensitivity Pregnancy/Lactation BBW= Fetal injury/death |
Enalapril SE | OTH 1st dose syncope HA/Dizziness LIFETHREATENING: angioedema, neutropenia, agranulocytosis |
Nifedipine | Procardia CCB |
Nifedipine Indications | HTN Angina |
Nifedipine Interactions | Other HTN meds= additive BB= increase risk of HF Increase Dig toxocity Alcohol=syncope Grapefruit juice=enhance absorption= additive Melatonin=counter effects = increase BP/HR |
Nifedipine CI | Hypersensitivity |
Nifedipine SE | HA Dizziness Peripheral Edema Flushing *Immediate action forms= reflex tachycardia DC gradually=rebound hypotension |
Doxazosin | Cardura A Blocker |
Doxazosin Indications | Urinary Retention--> BPH & HTN |
Doxazosin Interactions | Other HTN meds= additive Climetidine=increase half life Viagra (phosphodiesterase inhib) = additive |
Doxazosin CI | Hypersensitivity Hypotensive |
Doxazosin SE | Dizziness Dyspnea Athenia HA Hypotension Somnolence OTH 1st does phenomenon |
Metoprolol | Lopressor BB |
Metoprolol Indications | HTN HF |
Metoprolol Interactions | Diuretics + antiHTN= mask hypoglycemia NSAID=decrease effect Digoxin= increase risk of bradycardia Oral contraceptives = increase effects |
Metoprolol CI | Hypersensitivity MI= serious sinus bradycardia HR <45/ SBP <100 Mod-Severe HF Asthma Cardiogenic shock |
Metoprolol SE | Diminished sexual function Insomnia Unusual weakness/fatigue |
Losartan | Cozaar ARB |
Losartan Indication | HTN |
Losartan Interactions | NSAIDs= decrease K diuretics = increase K Diuretics/ antiHTN= additive Herbal: ephedra, licorice, ginseng= additive |
Losartan CI | Hypersensitivity Renal/Hepatic impairment K supplements- hyperkalemia Hx of angioedema |
Losartan SE | HA Dizziness OTH Rash Diarrhea AE= angioedema, acute renal failure, 1st dose phenomenon, fetal toxicity, neonatal mortality |
Hydralazine | Apresoline Vasodilator |
Hydralazine Indication | HTN HF |
Hydralazine Interactions | Other HTN meds= additive NSAID= decrease False coombs test Hawthorn= decrease |
Hydralazine CI | Angina Rheumatic Heart Dz MI Tachycardia Lupus= worsens Abrupt wd= rebound HTN |
Hydralazine SE | HA Tachycardia Palpitations Flushing Nausea Diarrhea BB=counteract reflex tachycardia *Na/fluid retenion= serious AE |
Furosemide | Lasix Loop diuretic |
Furosemide Indications | HTN HF (if fluid retention present) |
Furosemide Interactions | Cardiac glycosides (dig)= hypokalemia Corticosteroids, amp B, K depleting drugs = hypokalemia |
Furosemide CI | Hypersensitivty Anuria Hepatic Coma Severe fluid/electrolyte depletion |
Furosemide SE | Hypokalemia Dehydration Hypotension OTH *Ototoxicity |
Spironolactone | Aldactone K sparing diuretic, Aldosterone antagonist |
Spironolactone Indications | HTN Edema- HF |
Spironolactone Interactions | Ammonium chloride= acidosis ASA, NSAIDs= decrease Digoxin= decrease effects of dig K supplements, ACE inhibitors, ARBS= hyperkalemia |
Spironolactone CI | Anuria Renal impairment Hyperkalemia Pregnancy/Lactation |
Spironolactone SE | Hyperkalemia Women: menstrual irregularities, hirsutism, breast tenderness |
Hydrochlorothiazide | Microzide Thiazide diuretic |
Hydrochlorothiazide Indication | HTN Edema-HF |
Hydrochlorothiazide Interactions | Other HTN med= additive Decrease effectivess of anticoag, sulfonylureas, antidiabetic drugs Cholestryamine and Colestipol= decrease absorption NSAIDS= renal toxicity Corticosteroids, amp B = increase K loss= hypokalemia |
Hydrochlorothiazide CI | Anuria Hypersensitivity Pre-eclampsia Eclampsia Pregnancy induced HTN |
Hydrochlorothiazide SE | Na/K imbalances Teach increase K in diet Gout attacks= due to hyperuricemia |
Digoxin | Lanoxin Cardiac Glycoside |
Digoxin Indication | HF |
Digoxin Interactions | Diuretics=hypokalemia= dysrhythmias Ace inhib, spironolactone, ARB= hyperkalemia Positive inotropic drug= additive BB= additive bradycardia Antacids, cholesterol lowering drugs= decrease absorption Ginseng= increase risk of dig tox Ma huang, ephedra |
Lisinopril | Prinivil Ace Inhib |
Lisinopril Indications | HTN HF |
Lisinopril Interactions | NSAIDS= decrease Diuretic= additive K diuretic= hyperkalemia Increase lithium levels= toxicity |
Lisinopril CI | Hyperkalemia Angioedema Pregnancy |
Lisinopril SE | Cough HA Dizziness OTH Rash Hyperkalemia Taste disturbances Chest pain N/V/D Angioedema= SERIOUS |