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Antiinfective agents
respiratory pharm drugs
Question | Answer |
---|---|
What are the antiinfective drugs? | Pentamidine isethionate (NebuPent), ribavirin (Virazole), tobramycin (TOBI) and zanamivir (Relenza) |
What is Pentamidine indicated for? | the prevention of Pnuemocystis pneumonia (PCP) in high risk HIV infected patients |
What is Ribavirin indciated for? | the treatment of hospitalizaed infants with severe lower respiratory tract infection caused by RSV |
What is Tobramycin indciated for? | the management of chronic P. aeruginosa infection in cystic fibrosis. |
Zanamivir is indciated for what? | the treatment of uncomplicated acute illness caused by the influenza virus |
Why is aerosol administration used for pentamidine? | local traget delivery, with fewer side effects |
How is pentamidine administrated? | the Respirgrad II nebulizer, 5-7 L/min |
Mode of action for Pentamidine? | blocks RNA and DNA synthesis, inhibits oxidative phosphorylation and interfers with folate transformation. (unknown) |
How can you prevent local airway reaction with pentamidine? | use a beta-adrenergic like ipratropium |
Concerns with using pentamidine are what? | risk of infection with TB and exposure to the drug itself |
What does RSV cause? | bronchiolitis and pnuemonia |
What is RSV-IGIV? | respiratory syncytial virus immune globulin intravenous, a sterile liquid formulation of IgG containing neutralizing antibody to RSV |
What is RSV-IGIV indicated for? | the preventionof serious lower respiratory tract infection with RSV |
What does RSV-IGIV offer? | a prophylactic alternative to the treatment of acute RSV infection with aerosolized ribavirin |
What is Palivizumab indciated for? | the prevention of serious lower respiratory treact disease caused by RSV |
What is Cystic Fibrosis? | an inherited disease of the exocrine glands, affecting the pancreas, respiratory system and apocrine glands. |
What is Respiratory Syncytial virus? | a virus that causes formation of syncytial masses in infected call structures |
What is PCP? | Pneumocystis pneumonia, an interstitial plasm cell pneumonia caused by the oraganism pneumocystis carinii. |