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Pharm def ch 19
HCC Pharm def ch 19 - Cholinergic Drugs
Question | Answer |
---|---|
Acetylcholine | (ACh) Neurotransmitter responsible for transmission of nerve impulses to effector cells in the parasympathetic nervous system (PSNS). (p. 297 |
Acetylcholinesterase (AChE) | Enzyme responsible for the breakdown of ACh (also referred to simply as cholinesterase). (p. 298) |
Alzheimer's disease | A disease that is characterized by progressive mental deterioration manifested by loss of memory, ability to calculate, and visual-spatial orientation, as well as by confusion and disorientation, (p. 298) |
Cholinergic drugs | Drugs that stimulate the PSNS by mimicking ACh. (p. 298) |
Direct-acting cholinergic agonists | Cholinergic drugs that bind directly to cholinergic receptors to activate them, (p. 298) |
Indirect-acting cholinergic agonists | Cholinergic drugs that work indirectly by making more ACh available at the receptor site. (p. 298) |
Irreversible cholinesterase inhibitors | Drugs that form a permanent covalent bond with cholinesterase. (p. 298) |
Miosis | Contraction of the pupil, (p. 298) |
Muscarinic receptors | Effector-organ cholinergic receptors located postsynaptically in the smooth muscle, cardiac muscle, and glands supplied by parasympathetic fibers; so named because they can be stimulated by the alkaloid muscarine, (p. 297) |
Nicotinic receptors | Cholinergic receptors located in the ganglia (where presynaptic and postsynaptic nerve fibers meet) of both the PSNS and the sympathetic nervous system; so named because they can be stimulated by the alkaloid nicotine, (p. 297 |
Parasympathomimetics | Another name for cholinergic drugs that mimic the effects of ACh. (p. 298) |
Reversible cholinesterase inhibitors | Drugs that bind to cholinesterase for minutes to hours but do not form a permanent bond. (p. 298) |