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Pharmacology 3041
Representative Drugs
Term | Definition |
---|---|
Bethanechol | Cholinergic: increases detrusor muscle tone and GI motility. Adverse Reactions: bronchospasm, hypotension, tachycardia, seizures |
Atropine | Anticholinergic: preanesthetic; treatment of bradycardia, biliary colic, intestinal hypertonicity & muscarinic agonist poisoning. Adverse Reactions: glaucoma, tachycardia, severe bradycardia, gastric outlet obstruction, urinary retention, heat stroke. |
Neostigmine | Cholinesterase Inhibitor: used in treatment of neuromuscular disorders such as Myasthenia Gravis Adverse Reactions: arrhythmias, bradycardia, AV block, cardiac arrest, syncope, severe hypotension, respiratory arrest/depression, bronchospasm, seizures. |
Physostigmine | Cholinesterase Inhibitor: Adverse Reactions: cholinergic crisis, bradycardia, AV block, arrhythmias, severe hypotension, syncope, cardiac arrest, bronchospasm, respiratory depression/arrest, pulmonary edema, paralysis, seizures, hallucinations |
Echothiophate | Cholinesterase Inhibitor: binds irreversibly to acetylcholine binding site on pseudocholinesterase; treatment of glaucoma and incr. IOP. |
Pralidoxime | Antidote to inhibition of cholinesterase in organophosphate toxicity (reactivates cholinesterase). Adverse Reactions: cholinergic sx exacerbation |
Edrophonium | Reversible cholinesterase inhibitor: anesthesia adjunct; neuromuscular disorders; given as challenge dose to differential diagnosis of myasthenic crisis vs. cholinergic crisis. Adverse Reactions: cholinergic rxn, arrhythmias, bradycardia, hypotension, |
Atracurium | Neuromuscular Blocker: competitive, non-depolarizing nm blocker. Antagonizes ACh receptors on motor endplate. Adverse Reactions: Respiratory depression, apnea, malignant hyperthermia, seizures, bronchospasm, hypotension, cardiac arrest, arrhythmias |
Pancuronium | |
Succinylcholine | |
Dantrolene | |
Epinephrine | |
Albuterol | |
Prazosin | |
Propanolol | |
Baclofen | |
Diazepam | |
Clonidine | |
Methyldopa | |
Resperine | |
Levodopa/Carbidopa | |
Amantadine | |
Pramipexole | |
Bromocriptine | |
Entacapone | |
Selegiline | |
Donepezil | |
Memantine | |
Interferon Beta | |
Dimethyl Fumarate | |
Mitoxantrone | |
Phenytoin | |
Carbamazepine | |
Valproic Acid | |
Phenobarbital | |
Morphine | |
Pentazocine | |
Naloxone |