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Rush Nursing Pharm1
Pharm test #1 flashcards
Question | Answer |
---|---|
What happens in response to alpha1 activation? | Vasoconstriction of blood vessels, and mydriasis. (dilation of pupil). |
Where are alpha2 receptors? | Alpha2 receptors are on the presynaptic terminal of neurons that secrete NE. |
What happens in response to alpha2 activation? | Inhibits NE release. Little therapeutic significance. |
Where are beta1 receptors? | Heart, kidney. |
What happens in response to beta1 activation? | Increased rate, contraction, renin release in kidney |
Where are beta2 receptors? | Bronchi, arterioles, uterus, liver, skeletal muscle. |
What is the response to beta2 activation? | Bronchi dilate, liver increases glycogenolysis, skeletal muscle contracts, uterus relaxes, arterioles dilate. |
What happens to ACh? | It is destroyed by acetylcholinesterase, which lives on the surface of the postjunctional cell. |
What are the 2 substances that ACh-ase breaks ACh into? | Choline and acetate.Choline is taken back up for reuse. |
What happens to NE? | It is taken back up by presynaptic neuron. |
Where are alpha1 receptors? | Eyes, blood vessels, bladder, prostatic capsule. |
What would a cholinesterase inhibitor do? | Keep ACh from breaking down. |
What are some cholinesterase inhibitors? | Insectisides such as organophosphates. |
What would be symptoms of organophosphate poisoning? | Bronchoconstriction, profuse salivary and gastric secretions, laryngospasm. |