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Pharm1 Chapter21
Question | Answer |
---|---|
Atrial fibrillation | A common cardiac dysrythmia involving atrial contractions that are so rapid that they prevent full repolarization of myocardial fibers between heartbeats |
Automaticity | A property of specialized excitable tissue that allows self activation through the spontaneous development of an action potential, as in the pacemaker cells of the heart |
Cardiac Glycosides | Glycosides (carbohydrates that yeilds a sugar and non-sugar upon hydrolysis) that are derived from the plant species Digitalis purpurea and are used in the treatment of heart disease |
Chronotropic Drugs | Drugs that influence the rate of the heartbeat. Positive increase and negative decrease |
Dromotropic Drugs | Drugs that influence the conduction of electrical impulses of the heart. Positive increase and negative decrease |
Ejection Fraction | The proportion of blood that is ejected during each ventricular contraction compared to the total ventricular volume. It is an index of left ventricular function; normal is around 65% |
Heart Failure | An abnormal condition in which cardiac pumping is impaired as a result of myocardial infarction, ischemic heart disease, or cardiomyopathy. |
Inotropic Drugs | Drugs that influence the force of contraction of the muscle, especially the muscles of the heart. Positive increase and negative decrease |
Left Ventricular end-Diastolic Volume | The total amount of blood in the ventricle before it contracts, or preload. Ventricular diastole begins with the onset of the second heart sound and ends with the onset of the first heart sound. |
Refractory Period | The period during which a pulse generatoe (ex. The SA node of the heart) is unresopnsive to an input signal, and during which it is impossible for the myocardium to respond. The cardiac cell is readjusting its sodium and potassium levels |
Therapeutic index | The range of drug levels in the blood that is considered beneficial as opposed to toxic or ineffective. |
Normal therapeutic levels of Digoxin in the body should be between? | 0.5 and 2ng/mL |
Digoxin is indicated for? | both heart failure (<60BPM) and atrial fibrillation and flutter |
What routes are used to administer Digoxin/ | Oral (PO) and Injection (IV) |
What is a "Digitalizing Dose" | An initial dose "loading dose" that is given to bring serum levels of the drug up to therapeutic levels |
Two cammon PDI's (Phosphodiesterase Inhibitors) | inamrinone and milrinone |
What is a supraventricular dysrythmia | A atrial dysrythmia (ex. Atrial fibrilation or atrial flutter) |
What is the most common cardiac glycoside drug | Digitalis |
A patient is experiencing digitalis toxicity. The drug that is indicated for reversal would be? | Digoxin immune Fab |
Before giving oral digoxin, the nurse discovers that the patients radial pulse is 55BPM. The nurses next action would be to? | Check Apical pulse for one minute |
Wht is true reguarding digoxin and potassium levels? | Low potassium levels increase the chances of digoxin toxicity |
What is the true color of intraveneous amrinone? | clear yellow |
What are the signs and symptoms of Digoxin toxicity? | Anorexia, Visual Changes, Nausea and Vomiting, and bradycardia |
What are the two main Mechanisms of Action in PDI's? | Vasodialation and positive inotropic effect |