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Pharm C48
Term | Definition |
---|---|
Warfarin is an... | anticoagulant |
Warfarin therapeutic actions | interfere with the normal cascade of events involved in the clotting process |
Warfarin causes decrease in... | vitamin K which causes blood to thin |
Vitamin K counteracts... | Warfarin |
Warfarin pharmacokinetics | taken orally, absorbed readily through the GI tract, metabolized in the liver and excreted in the urine and feces, onset action of 3 days and effect lasts 4-5 days |
Warfarin Contraindications and cautions | HF, thyrotoxicosis, senility, psychosis |
Warfarin adverse effects | Bleeding, alopecia and dermatitis, bone marrow depression, prolonged and painful erection, GI upset, diarrhea, hepatic dysfunction |
Warfarin Drug-drug interactions | Has documented drug-to-drug interactions with a vast number of other drugs, do not eat green leafy vegetables when on heparin |
Discharge teaching for client on anti-coagulation therapy | -brush teeth softly with soft bristle tooth brush -wear medical alert bracelet -instruct on warning signs of bleeding -instruct pt to obtain follow-up labs regularly |
Urokinase indications | lysis of PE or PE with unstable hemodynamics in adults |
Urokinase actions | Converts endogenous plasminogen to plasmin, which breaks down fibrin clots, fibrinogen, and other plasma proteins, lyses thrombi and emboli |
Urokinase adverse effects | headache, angioneurmtic edema, hypotension, skin rash, bleeding, breathing difficulties, bronchospasm, pain, fever, anaphylactic shock |
Clotting factors and liver disease | Liver disease, in which clotting factors and proteins needed for clotting are not produced |