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OMFP 2 CUS
Chronic Ulcerative Stomatitis
Chronic Ulcerative Stomatitis | an immune-mediated disorder that affects the oral mucosa, probable cause is autoantibodies against a nuclear protein similar to p63 which involves epithelial growth and differentiation. |
Clinical features of Chronic Ulcerative Stomatitis | has a similar look to lichen plantus or desquamative gingivitis on the buccal mucosa with ulcers surrounded with white patchy zones of erythema and streaky keratosis. |
Demographics and diagnosis of Chronic Ulcerative Stomatitis | White women over 60 years old are most susceptible. Diagnosis needs a biopsy and tissue can be assessed by direct immunoflourescence that identifies the protein p63. |
Microscopic features of Chronic Ulcerative Stomatitis | Atrophic epithelium, large number of plasma cells and lymphocytes in inflammatory infiltrate. |
Treatment and prognosis of Chronic Ulcerative Stomatitis | Can treat with corticosteroids but it is not always effective. for patients with recalcitrant cases hydrochloroquine may be given which is an antimalarial agent. |
Differential Diagnosis of Chronic Ulcerative Stomatitis | Lichenoid mucositis, Lichen Plantus, Erythema Multiform, Lupus Erythematosus, Vesiculo-Bullous Disorder |