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Pharm2 Chapter 41
Question | Answer |
---|---|
1. What is mycosis | a. An infection caused by pathologic fungus |
2. Molds are | a. Multicellular |
3. Yeasts are | a. Single celled organisms |
4. Yeasts produce how | a. By budding |
5. Molds are characterized by what | a. Long, branching filaments called hyphae |
6. The most commonly used antifungal drug is by what method | a. Topical |
7. Some examples of topical antifungal drugs are | a. Clotrimazole (lotrimin), miconazole (monistat), nystatin |
8. Fungi are difficult to treat because what reason | a. Chemicals that kill fungi are not tolerate by humans |
9. What is the oldest antifungal drug | a. Amphotericin B |
10. A major group of antifungal drug that includes: ketoconazole, miconazole, and clotrimazole | a. Imidazoles |
11. These require external carbon source | a. Fungi |
12. Another major group including: amphotericin b and nystatin is called what | a. Polyenes |
13. When giving an infusion of amp b, what s/e should you monitor for | a. Chills, fever, and malaise |
14. The drug of choice for systemic fungal infections is | a. Amp b |
15. 2 drugs that are used systemically are | a. Amp b and fluconazole (diflucan) |
16. s/e of amp b include | a. Renal toxicity, neurotoxicity- seizures and praesthesias |
17. What pretreatment may reduce the severity of infusion related reactions | a. Antipyretic antihistamine and antiemetics |
18. When using antifungals you should obtain what | a. Baseline VS, CBC, liver function studies and ECG |
19. If giving amp b IV, you should use what | a. The most distal vein possible |
20. Nystatin suspension, taken orally should be | a. Swished in the mouth thoroughly as long as possible before swallowing |
21. A problem of most concern in pts about to receive antifungal meds are | a. Those with hepatic disease |
22. A common underlying source of drug interactions with an antifungal are | a. Cytochrome P-450 enzyme system |
23. When taking griseofulvin, you should look for what potential s/e | a. Blood dyscrasis |