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Mycosis Fungoides

OMFP II

QuestionAnswer
What is an alternate name for Mycosis Fungoides? An alternate name for Mycosis Fungoides is Cutaneous T-cell Lymphoma.
Complete this sentence: Mycosis Fungoides is the most common form of ___. Mycosis Fungoides is the most common form of primary cutaneous T-cell Lymphoma.
How do skin lesions progress in Mycosis Fungoides? Skin lesions of Mycosis Fungoides progress in stages as psoriasis-like patches first, then nodular or indurated plaques to later look like tumor-like excrescences.
True or False: All three stages of Mycosis Fungoides skin lesions can be seen in one patient. This is true - All three stages of Mycosis Fungoides skin lesions can be seen in one patient.
Where are Mycosis Fungoides lesions most commonly found and where are they most uncommon? Mycosis Fungoides lesions are mostly found on the chest, breasts, limbs, and flexures while oral lesions are uncommon.
Sezary syndrome can represent a variant of Mycosis Fungoides - how is this syndrome defined? Sezary syndrome is characterized by erythroderma, generalized lymphadenopathy, and clonal neoplastic T cells containing cerebriform nuclei found in the skin, lymph nodes, and blood.
How common is Mycosis Fungoides? Mycosis Fungoides is rare with about 1,200 cases in the U.S. annually.
True or False: Mycosis Fungoides has a female predilection. This statement is false. Mycosis Fungoides has a male predilection of 2:1.
In what age range is Mycosis Fungoides most common? Mycosis Fungoides is most common in the fourth to sixth decades of life with a mean age of 55-60 years old.
True or False: African Americans are affected by Mycosis Fungoides more frequently. This is true - African Americans are affected by Mycosis Fungoides more frequently.
How is Mycosis Fungoides diagnosed? Mycosis Fungoides is diagnosed using a biopsy of lesional tissue and established through microscopic examination of the specimen.
What is Mycosis Fungoides characterized by on a microscopic level? Mycosis Fungoides is characterized by CD4+ cells that have an atypical form with cerebriform nuclei. It appears as clusters of atypical lymphocytes grouped in intraepidermal vesicles called Pautrier's microabscesses.
What do early lesions of Mycosis Fungoides appear as? Early lesions of Mycosis Fungoides show atypical lymphocytes lining up along dermal-epidermal junctions extending into the epidermis.
What is the treatment for Mycosis Fungoides? Treamtment for Mycosis Fungoides includes phototherapy or chemotherapy, topical therapy, and radiotherapy which are used to treat malignancy.
What is the prognosis for patients with Mycosis Fungoides? Mycosis Fungoides does not have a cure and progresses slowly. A small number of cases will progress to Sezary syndrome.
How can the prognosis of Mycosis Fungoides differ? Clinical staging of Mycosis Fungoides is considered the most prognostic factor as large cell transformation leads to a poor prognosis. However, the CD8 predominant form shows a better prognosis, except in HIV patients.
What can be included in a differential diagnosis list for Mycosis Fungoides? The differential diagnosis list for Mycosis Fungoides includes Psoriasis, Eczema, Pityriasis, Lichen Planus, Sarcoidosis, Leukemia cutis, B-cell Lymphoma, and Pseudo Lymphoma.
Created by: seema.prakash
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