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Inflamm-AO
Patho-9/3 AO
Question | Answer |
---|---|
Example of physical barrier | epithelial cells (skin-mucous membranes) |
Example of biochemical barrier | normal bacteria flora |
Classic Symptoms of inflammation | redness, swelling, pain, heat, loss of function |
Steps of Inflammatory Response | 1. injury 2. Cells release chemical mediators (histamines, chemotactic factors, leukotrienes, prostaglandins) 3. Vasodialation-inc blood flow 4. Leukocytes move to the site of injury 5. Phagocytosis-removal of bacterial prod |
Local manifestations of acute inflammation | swelling, pain, heat, redness |
Systemic manifestations of acute inflammation | fever, inc leukocytes, inc levels in circulating plasma protien |
Consequence Macrophage infiltration | pus/granuloma |
Differentiation of macrophage into lg epithelioid cells | form center of granuloma and can become calcified |
Consequence Tissue repair | scar tissue |
What is an antigen? Where are antigens found? | initiates an immune response. B&T cells |
What role do B and T cells play? | T-kill target, reg immune response, helper to prevent cancer and infection B-produce antibodies |
IgG | most common. Production activity against infection. Crosses placenta |
IgA | secretatory cholestrum, tears, etc |
IgM | First and largest antibody produced bound to B lymphocytes. |
IgE | mediator of many common allergic reactions |
Type 1 hypersensitivity response | IgE mediate reaction ex:asthma exacerbation |
Type II hypersensitivity response | tissue specific reaction ex: blood transfusion reaction |
Type III hypersensitivity response | immune complex mediated reaction ex. systemic lupus erythematosus |
Type IV hypersensitivity response | cell-mediated reaction ex: organ tissue rejection |
Primary (congenital) immune deficiency | genetic. Ex: DiGeorge syndrome |
Secondary (acquired) immune deficency | acquired complication of physiological AIDS |
Which cell types associated with the inflammatory response participate in phagocytosis? | Neutrophils Macrophages Monocytes |