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Unit 2 2514

IBD Medications

QuestionAnswer
The drug therapy of IBD includes which 5 types of drugs? 5-aminosalicylates (sulfasalazine), glucocorticoids (Hydrocortisone), immunosuppressants ( cyclosporine), immunomodulators (Infliximab) and antibiotics (Metronidazole)
Which drug is used to treat mild or moderate UC and Crohn's disease and to maintain remission after symptoms subside. Sulfasalazine (5-aminosalicylates)
What is the MOA of a 5-aminosalicylates such as Sulfasalazine? Suppresses prostaglandin synthesis and migration of inflammatory cells into the affected areas. This reduces inflammation.
Side effects including adrenal suppression, osteoporosis, increased susceptibility to infection and Cushing's syndrome are common for which class of drug? Glucocorticoids
What is the MOA of Infliximab Inhibits the Tumour Necrosis Factor (TNF) which is a key immunoinflammatory modulator.
The patient with Crohn's Disease flare up develops a fever, chills, chest pain, hypotension and urticaria after IV infusion. What medication could have provided these adverse effects? Infliximab (Immuno-modulator)
When administering this drug you tell the patient who has been admitted for acute UC not to have any grapefruit juice since it can increased the effect of the drug upto 200%. Which drug is this? Cyclosporine (immunosuppressant). A compound in grapefruit juice inhibits CYP3A4 slowing the metabolism of cyclosporine and raising the serum levels by 50 % to 200% increasing the risk for toxicity.
What is the MOA for the immunosuppressant Cyclosporine? The drug acts on B cells and cytotoxic T cells to suppress the immune system and by this reduce inflammation in patients with IBD.
The adverse effect for the patient taking the immunomodulator Infliximab would include? high risk for TB infection and other opportunistic infections, since the body's immune system is suppressed.
Created by: Shamilla
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