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Antiemetic drugs

Antiemetic Agents

TermDefinition
Phenothiazines Drugs Prochlorperazine (generic) Chlorpromazine (generic) Perphenazine (generic)
Phenothiazines Actions Actions Depresses various areas of the central nervous system (CNS)
Phenothiazines Indications Indications Treatment of nausea and vomiting
Phenothiazines Contraindications Contraindications Coma, severe CNS depression, brain damage or injury Severe hypotension or hypertension Severe liver dysfunction
Phenothiazines Caution Caution Renal dysfunction Moderate liver impairment Active peptic ulcer Pregnancy and lactation
Phenothiazines Adverse Effects Adverse Effects Drowsiness, dizziness, weakness, tremor, headache Hypotension, hypertension, cardiac arrhythmias
Phenothiazines Adverse Effects continued Dry mouth, nasal congestion, anorexia, pallor, sweating, urinary retention Menstrual disorders, galactorrhea, and gynecomastia Photosensitivity
Phenothiazines Drug-Drug Interactions Drug-Drug Interactions Other CNS depressants, including alcohol
Nonphenothiazines Drugs Metoclopramide (Reglan)
Nonphenothiazines Actions Actions Acts to reduce the responsiveness of the nerve cells in the CTZ to circulating chemicals that induce vomiting
Nonphenothiazines Indications Indications Prevention of nausea and vomiting
Nonphenothiazines Adverse Effects Adverse Effects Drowsiness Fatigue Restlessness Extrapyramidal symptoms
Substance P/Neurokinin 1 Receptor Antagonists Drugs Aprepitant (Emend) Rolapitant (Varubi)
Substance P/Neurokinin 1 Receptor Antagonists Actions Actions Act directly in the CNS to block receptors associated with nausea and vomiting
Substance P/Neurokinin 1 Receptor Antagonists Indications Indications In combination with other agents to prevent nausea and vomiting
Substance P/Neurokinin 1 Receptor Antagonists Pharmacokinetics Pharmacokinetics Given orally, metabolized in the liver, and excreted in urine and feces
Substance P/Neurokinin 1 Receptor Antagonists Contraindication Contraindication Allergy
Substance P/Neurokinin 1 Receptor Antagonists Caution Caution Pregnancy and lactation
Substance P/Neurokinin 1 Receptor Antagonists Adverse Effects Adverse Effects Anorexia, fatigue, constipation, diarrhea, liver enzyme elevation, dehydration
Substance P/Neurokinin 1 Receptor Antagonists Drug-Drug Interactions Drug-Drug Interactions Pimozide, warfarin, hormonal contraceptives
Miscellaneous Agents Drugs Dronabinol (Marinol) and nabilone (Cesamet) Contain the active ingredient of cannabis Hydroxyzine (Vistaril) May suppress cortical areas of the CNS Trimethobenzamide (Tigan) Not associated with as much sedation and CNS suppression as other agents
Created by: garmijos
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