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UE9 Med - BDR

Organogenèse - Exemples

QuestionAnswer
Cardiogenèse Endoderme viscéral contact aire cardiogène
Cardiogenèse Inhibiteur de Wnts
Cardiogenèse BMP2 (action activatrice combinée)
Cardiogenèse FGFs (action activatrice combinée)
Segmentation coeur TGFβ
Mise en place tube digestif BMPs 2
Mise en place tube digestif BMPs 4
Mise en place tube digestif BMPs 5
Mise en place tube digestif BMPs 7
Spécialisation cellules tube dig FGF
Spécialisation cellules tube dig Hox
Spécialisation cellules tube dig Shh
Activation gènes homéotiques Acide rétinoïque
Activation gènes homéotiques Fonction gradient concentratin
Activation gènes homéotiques Complexe Hox D
Complexe Hox D Partie proximale vers partie distale
Complexe Hox D Gène s'activent succéssivement
Complexe Hox D 5 gènes
Complexe Hox D D9 à D13
Anti-acnéique Acide rétinoïque (attention si enceinte)
Excès acide rétinoïque Activation D12
Excès acide rétinoïque Développement anormal tissu
Excès acide rétinoïque Polydactylie
Excès acide rétinoïque Synpolydactylie
Polyactylie 6 doigts
Synpolydactylie Fusion doigts (absence de sillon)
Synpolydactylie Mutation homozygote hox 13
1ère étape diff membres Niveau appareil extérieur
1ère étape diff membres Epaississement épiblaste (formation membre)
Zone mésodermique Détermine axe antéro-postérieur
Zone mésodermique ZPA (zone of polarizing activity)
Zone mésodermique Sécrète acide rétinoïque
Acide rétinoïque Substance morphogénique
Acide rétinoïque Diffuse vers extrémité antérieure membre
Created by: Flavien
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