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exam 3 patho

skin/burns, inflammation/immunity/infection; renal/bladder, neuro

QuestionAnswer
scratching, swelling, infection and self-treatment may alter appearance of skin
functions of skin temp control, barrier protection, secretion/absorption, vitamin d, immunological surveillance, mirror for internal disease processes, indicator of general health
layers of skin epidermis (outer), dermis (middle), hypodermis (inmost)
erythema reddened skin
induration hardening or thickening of skin, seen with positive tb skin tests
atrophy thinning and loss of skin layers; in all tissues of body
bulla large blister, in burns
telangiectasia fine, irregular red lines produced by dilation of capillaries, think spider veins
pustule papule filled w pus, think pimple
scale fragment of dry skin, think peeling or flaking
scar permanent replacement of normal skin w connective tissue, after cut heals
ulcer loss of epidermal and dermal tissue, can occur outside skin tissue as stasis ulcer or in stomach tissue as peptic ulcer
lichenification hardening or thickening of the skin w markings due to trauma, think little scabs from scratching too much
machule defined, flat area of altered pigmentation, think freckle
nodule solid lump greater than 0.5 cm in diameter, think knot on skin
papule raised, well-defined lesion, less than 0.5 cm in diameter; think bug bite or cystic acne which is a bump under the skin but doesnt have pustule
plaque raised, flat-topped lesion, greater than 2 cm, think eczema or psoriasis
vesicle small blister, think herpes blister
wheals (urticaria) transient pale, elevated papules w pink margins, think itchy allergic reaction
albinism genetic disorder, lack of pigmentation
vitiligo abnormalities in melanin production leading to discolored skin patches
melasma appearance of dark macules on face, more common in brown-skinned women
lentigos age spots
xerosis dry skin, more easily bruised, damaged
pruritus itching, various causes, treatment involves addressing underlying cause
telogen effluvium dec growth vs rest cycle of hair, overall thinning of hair--> due to stress, nutritional deficiencies and chemical overprocessing
alopecia areata sudden loss of hair in one area of scalp hair--> can reflect nutritional status or disease states
pitting psoriasis
clubbing chronic hypoxia
koilonychia (spooning) liver and thyroid problem
infections bacterial or fungal
paronychia pain and swelling around paronychial fold
onychomycosis fungal or yeast infection of nailfolds
onycholysis infection that causes nail plate to separate from nail bed
hyperhidrosis excessive sweat production, often palms, soles, axilla
anhidrosis diminished sweat production
hidraclenitis suppurativa clogging of apocrine glands
acne vulgaris multifactoral inflammation of these glands
comedome acne lesion, most common during puberty due to hormones, bacterial component (p. acnes)
acne rosacea middle aged adults, rosacea=inflammatory process
birthmarks present @ birth or develop during infancy
hemangiomas benign tumors of blood vessels (30% of newborns)
port wine stains permanent blood vessel abnormalities (0.5% population)
wood's light uses uv light that causes bacterial or fungi to grow
skin scrapings sample for suspected fungal lesions
patch testing identify substances to which patient has developed an allergy
skin biopsy performed to obtain tissue for microscopic examination
clinical photographs document the nature and extent of skin condition
nevi (moles) most common benign skin tumor, develop from melanocytes, irregular shape and varigated color
actinic keratosis premalignant lesion, rough, scaly, red plaques
lentigos premalignant skin lesion, brown spot (liver spots, age spots), benign but should be watched
malignant melanoma most lethal form of skin cancer, originates in melanocytes, benign on surface but penetrates and metastasizes, uv plays role; diagnosed thru biopsy
malignant melanoma predictable stages benign nevus, dysplastic nevus, radial growth phase of melanoma, vertical growth phase metastasis
most @ risk for malignant melanoma fair skin, 50-100 moles, history of sunburn or indoor tanning
ABCDE of malignant melanoma asymmetry, border, color, diameter, evolving
treatment of malignant melanoma surgical removal of melanoma, staging, sentinel lymph node biopsy, chemotherapy
basal cell carcinoma most common form of skin cancer, 90% skin cancer in US rarely metastasizes, begins as small, dome-shape bump, shiny, translucent texture, grow slowly and deeply; diagnosed thru biopsy
treatment of basal cell carcinoma cured w surgery
squamous cell carcinoma risk inc w age/uv exposure; appears red, crusted, or scaly patch, maybe non-healing ucler or firm, red nodule; may develop from actinic keratosis
diagnosis and treatment of squamous cell carcinoma biopsy, treated if caught early, can invade and destroy surrounding tissue, those on lip, or ear are particularly aggressive; if untreated, can metastasize
candida albicans yeast infections
superficial fungi dermatophytes, tinea (ringworm)--> live on keratinized tissue, pruritus, lesions, cosmetic changes to skin, hair, nails can occur
invasive fungi can cause septicemia
fungi skin infections diagnosed thru microscopic exam and wood's light
shingles painful vesicular eruption along the area of distribution of sensory nerves from one/more posterior ganglia; caused by herpes zoster and treated w antivirals
herpes simplex type 1 occurs on mouth, type 2 occurs in genital area
human pailloma virus (hpv) benign genital warts (or anywhere on body), risk of cervical, anal or rectal changes
pressure ulcers decubitis ulcers, bedsores; involve the breakdown of skin due to prolonged pressure, friction and shear, & insufficient blood supply especially over bony prominences
4 stages of pressure ulcers 1-skin red and closed/no blanching, 2-open skin (ulcer), painful, 3-extends into tissue, may see fat, not muscle, tendon or bone, 4-damage into muscle, bones, tendons
prevention of pressure ulcers repositioning patients and skin moisture
venous stasis ulcers diminished circulation in lower extremities; blood pools in veins, skin damage develops, slow healing
arterial ulcers related to insufficient blood supply to extremities, painful, pale, cool to the touch, hairless skin, deep, red, yellow or black sores
neuropathic ulcers ocur due to reduced blood supply to nerves (often related to diabetes)-loss of feeling; found on bottom of feet, reddish to brown-black, margins well-defined, punched out look, surrounding skin calloused
contact dermatitis delayed hypersensitivity, inflammatory reaction of skin to physical, chemical, or biological agents (metal, chemicals, poison ivy)
irritant type contact dermatitis response to nonallergic reaction
allergic type contact dermatitis allergic reaction resulting from exposure to contact allergens
seborrheic dermatitis inflammation due to excessive secretion of sebaceous glands, red lesions, dandruff
urticaria hives, wheals, can be accompanied by angioedema; acute treated with antihistamines; chronic has autoimmune component
angioedema swelling of eyes, face, lips, mucous membranes
inflammatory lesions histamine released by mast cells, immunological, chemical, physical stimuli
2 most common burn etiologies are flame and scald
burns thermal, chemical, electrical, radiation; all depend on temp of burning agent, duration of contact and thickness of skin
superficial damage only to epidermal layer, vasodilation causes redness to skin; no blisters, healing in less than 1 week
superficial partial-thickness injuries char epidermis and papillary dermis; edema and epidermal blisters; skin is wet, raw, pink or white; painful, will heal in 3-6 weeks, scarring may occur
deep partial-thickness injuries thru epidermis and dermis; skin may be mottled, blistering
full-thickness injuries damage to epidermis, dermis, hair follicles, and all underlying structures; nerve endings destroyed, so pain is rare; skin-white, black, brown, or red; significant edema in surrounding tissues
rule of nines rapid, used pre-hospital & in emergent phase; body divided into 11 regions that represent 9% each of BSA, w perineum @ 1%; accurate for adults
lund and browder method more precise method of estimating the extent of a burn; body is divided into smaller sections of tbsa and %
minor burn injury partial thickness less than 15% tbsa, full-thickness less than 2% tbsa (excluding eyes and hands)
moderate burn injury partial thickness 15-25% tbsa, full-thickness less than 10% (excluding special care areas)
major burn injury partial thickness greater than 25% tbsa, full-thickness in children; all full thickness burns exceed 10%; all involve eyes, ears, face, hands, feet, perineum, or joints inhalational injury, electrical injury, concurrent trauma and poor-risk patients
zone of coagulation deepest point of injury, most irreversible damage
zone of stasis dec tissue perfusion, potentially reversible damage
zone of hyperemia outer zone, reddened due to vasodilation, minimal tissue damage
normal organ function disrupted if tbsa >30%
cell damage and death release vasoactive substances inc vascular permeability, w fluid and protein shift from ICF to ECF; greatest 6-8 hrs post-injury; cell damage: leak of potassium into ecf inc risk hyperkalemia
hypotension, tachycardia, dec urine output specific hypovolemic shock:burn shock; fluid resuscitation critical
hypermetabolic state energy needs inc 50-100%, bmr 1.3x greater than normal on average; nutritional supplementation calculated as 25 kcalxbody weight (kg) + %tbsa
cardiovascular effects of burns hemodynamic instability, fluid, sodium and protein losses: fluid loss causes dec in vascular volume, cardiac output and bp lactated ringer's is administered; systemic edema, hyponatremia, hyperkalemia
pulmonary effects of burns upper airway injury; inhalation injury: related to carbon monoxide; airway edema: rapid progression, stridor (immediate intubation); patient is @ risk acute respiratory failure and distress
renal effects of burns altered function as result of dec blood volume; impairment to immune system diminishes resistance to infection; loss of skin: inability to regulate body temp; gi complications: paralytic ileuus and curling's ulcer
immune system effects of burns neg impact on immune function, reduction of complement system, Ig production, dec wbc production/function, dec t helper cells; inc infection risk; debridement=used to stimulate blood flow to area of injury, dec risk of incetion
if 35% tbsa, dec blood flow to gi tract; secondary to hypovolemia, dec motility and nutrient absorption, paralytic ileus
to protect gastric mucosa enteral feedings, proton pump inhibitors (ppis) and h2 blockers; help to prevent curling's ulcer (gastric ulcer in severely burned individuals)
priority of burn care ABCDEF- airway, breathing, circulation, disability, exposure, fluid resusitation
infection/sepsis after burns skin barrier broken, immunosuppression w suppressed t cell and macrophage function, dec circulation to injury, prolonged hospitalization staph aureus/mrsa, would infection turns into cellulitis, then necrotizing fascitis, to sepsis (blood stream)
adult respiratory distress syndrome (ards) leading cause of death in severe burn injuries; risk inc when burn >40% tbsa or full-thickness burn >20%
burns lead to ards capillary hyperpermeability causes fluid to leak into alveoli, gas exchange impaired-tachypnea, nasal flaring, accessory muscle use, cough, hypotension, tachycardia, fever; mechanical ventilation needed
eschar tough, elastic, dead, burned tissue, compromises circulation causes excessive build up, ischemic and infarction or area may occur
compartment syndrome full thickness circumferential and near-circumferential skin burns
contractures epithelial replacement not possible if skin is burned below certain level with deep dermal and full-thickness burns
hypertrophic scarring scarring after burn injury w keloids
keloids raised scar on skin
goal of inflammation keep injury contained, prevent spread of injury, bring body's defenses to needed area
3 phases of acute inflammation inc vascular permeability, cellular chemotaxis, systemic response
vascular permeability rubor (redness), tumor (swelling), calor (heat), dolor (pain), loss of function (function laesa); fluid, wbcs, platelets travel to injury
histamine and bradykinin dilate vessels
cellular chemotaxis chemotaxis, leukocytosis, leukemoid reaction, margination
chemotaxis chemical signals attract wbcs and platelets
leukocytosis inc # of leukocytes (>10,000)
leukemoid reaction severe elevation in leukocytes (>50,000)
margination wbcs line up along endothelium, release inflammatory mediators
granulocytes neutrophils, eosinophils, basophils
neutrophils 6-24 hrs, prep for repair of tissue damage
basophils when organism enters body, cytokine and protease production
eosinophils when immune system is activated, inflammatory mediators
agranuloyctes monocytes and lymphocytes
monocytes 24-48 hrs, boost immune response
lymphocytes viral infections, inc blood flow
phagocytosis respiratory burst releases free radicals that destroys microbes
mature neutrophils segmented nuclei
immature neutrophils known as bands
cytokines released by wbcs, stimulate the liver to release acute phase proteins which facilitate wbc phagocytosis
chemokines proteins that attract leukocytes to endothelium
systemic response fever, lympphoadenopathy, anorexia, sleepiness, lethargy, anemia, weight loss
fever >100.2 F
pyrogens substances that cause fever; activate PGs to reset the hypothalamic temperature (regulating center)
higher temps inc wbc efficiency
fever onset shivering to inc temp
fever break sweating to reduce temp
histamine produced by basophils, platelets and mast cells; arteriolar vasodilation, large artery vasoconstriction, inc permeability of venules
prostaglandins released from wbcs and cell membranes
TNF-alpha and interleukins inflammatory signals produced by macrophages; induce fever, loss of appetite, and lethargy; promote weight loss and cachexia
outcomes of acute inflammation complete resolution, healing by connective tissue (regernation of normal cells do not occur, excessive proliferation of connective tissue, fibrous scar tissue formed), chronic, persistetn inflammation (resolution does not occur, extensive tissue damage)
chronic inflammation inflammation for weeks or months w no resolution or healing
persistent infection tuberculosis, syphilis, viruses
hypersensitivity disorders rheumatoid arthritis, systemic lupus erythematosus (sle)
exposure toxic agents coal dust-anthracosis (black lung)
atherosclerosis chronic inflammatory disease
granuloma formation macrophages aggregate and are transformed into epithelial-like cells
differences bw chronic and acute inflammation predominance of monocytes, lymphocytes, and macrophages; continual secretion of cytokines damages healthy tissues stimulating further info
host human or animal colonized by pathogen
pathogen microorganisms capable of causing infectious diseases
colonization pathogen living in host
infection invasion, colonization, and multiplication of pathogens
virulence ability to produce disease
reservoir pathogen source (person or inanimate object (fomite))
vector living being that can carry pathogen from reservoir to host (mosquito, tick, and flea)
epidemiology study of disease distributions
incidence number of new infection cases
prevalence number of active ongoing infections
endemic incidence and prevalence are stable
epidemic abrupt inc in incidence in location
pandemic global spread of disease
microbial flora organisms that live in or on the human body that secrete nutrients and competitively inhibit harmful pathogens
microbial flora do not cause infection/disease w/in normal area
opportunistic infection infection caused by microorganisms that flourish bc host's immune system is weakened
skin natural barrier due to thickness and low pH; harbors normal flora (staphylococcus, streptococcus, and candida)
respiratory tract possible entry point for thousands of microorganisms; cilia, mucous secretions, specialized immune cell help reduce infections
gastrointestinal tract contaminated food and drink, fecal-oral transmission; stomach pH, mucus, normal flora prevent infections
blood-blood transmission blood transfusions, sharing of needles; also enter thru mucous membranes, eyes and skin (hence universal precautions)
maternal-fetal transmission some pathogens can cross placental barrier; some thru childbirth; congenital infection passed from mother to child
incubation microorganisms begin replication w/o identifiable symptoms; short as 24 hrs or 2-3 months
prodromal initial symptoms appear, often vague and general
acute full infectious disease sign and symptoms are present and immune system is fully engaged
convalescent body containing the infection and progressively eliminating the pathogen; days, weeks, or months
resolution pathogen eliminated from the body
stages of infection incubation, prodromal, acute, convalescent, resolution
gram stain most common clinical microbiology stain, results based on cell wall of bacteria
gram pos thick peptidoglycan cell wall; purple
gram neg thin cell wall; red
best prevention for infection hand washing
disinfecting equipment bw patients stethoscopes
vaccines are most efficient method of controlling contagious diseases
treatment of infectious diseases antimicrobial agents, immunological boosting agents, surgical removal of infected tissues
staphylococcal gram-pos, part of normal flora
s. aureus colonizes skin, vagina, nares and oropharynx; most virulent staph infection bc of toxins and proteases, leading cause of health-care associated infections; antibiotic resistance mrsa and vrsa
streptococcal gram pos, strains cause infections in humans
s. pyogenes gabhs (group a beta hemolytic streptococcus)
pseudomonas aeruginosa gram neg, most common pathogen isolated from patients hospitalized for 1 week +; can infect many systems, may be life threatening
bacterial meningitis fatal, more severe than viral; fever, nuchal rigidity, headache, and photophobia common signs
kernigs sign extending leg up in laying down position; associated with bacterial meningitis
brudzinskis sign moving knees and neck up, associated with bacterial meningitis
lumbar puncture is needed for diagnosis of bacterial meningitis
eschericia coli (e coli) lives in intestines of healthy cattle, undercooked meat means of transmission; common cause of utis in women
hemolytic uremic syndrome small blood vessels in kidneys become damages and inflamed, from diarrheal illness w e coli
clostridium difficile prolonged antibiotic use that distorts normal flora of gi tract enables overgrowth
lyme disease bariela burgorferi, deer tick transmits, erythemia migrens may be present, arthritis and nerve involvement may develop, difficult to diagnose
viruses are acellular, use host cell's metabolic processes; have either dna or rna surrounded by protein coat; can cause acute/chronic/latent infections or cancer cell growth
common cold adults 3-4 colds per year, rhinovirus, adenovirus, coronavirus; direct contact or droplet
influenza virus a, b, or c types; annual outbreaks, high mutation rate leads to seasonal vaccine, abrupt onset of symptoms may last 2+ weeks
epstein barr virus (ebv) cause of mononucleosis; more than 90% of population infeted, may not develop into mono; pharyngitis, severe fatigue, lymphadenopathy, and splenomegaly present; spread thru saliva
herpes simplex virus (hsv) 2 forms HSV-1 (cold sores) and HSV-2 (genital infection)
acute herpes vesicular lesions w active viral particles
latent herpes reactivations often occurs during times of stress
varicella zoster causes chickenpox (vaccine available); rash first appears on scalp and progresses over body
shingles reactivation of varicella zoster; remains dormant along nerves (vaccine available)
poliomyelitis fecal-oral route transmission; virus damages motor neurons; abortive, aseptic meningitis, and paralytic; vaccines available; symptoms: muscle loss, fatigue, slow progression
fungi mold-like organisms; mycoses=fungal infections
dermatophytes tinea (ringworm), superficial infections involving the skin, hair, or nails
candida part of normal flora, pathogenic when it overgrows
thrush oropharyngeal candidiasis
vulvovaginal candidiasis yeast infection
candida albicans can cause fatal disseminated infection, especially in immunocompromised
protists protozoa, giardiasis and malaria
helminths worms that cause infection; eneteroblasis (pinworms), ascariasis (roundworm), hookworm, tapeworm; more prevalent in tropical areas
insects directly cause disease or severe as vector
malaria plasmodium protozoan, transmitted by anopheles mosquito; destroys rbcs, affects liver and spleen; malaria prophylaxis; jaundice, chills, hemolytic anemia, hepatomegaly, splenomegaly
toxoplasmosis toxoplasma gondii protozoan, cysts present in cat feces, pregnant women and immunocompromised @ risk; can be transmitted to fetus and cause encephalitis
prions crutzfeldt-jaokb disease (cjd); fatal degenerative neurological disease, spongiform appearance of brain; bovine spongiform encephalopathy: mad cow disease, spread via meat and bone meal fed to cattle
antigens non-self substances, target of immune response
immunodeficiency weakened immune system
autoimmunity attack self cells
hypersensitivity overreactive immune system
immunocompetence ability to protect oneself due to strong immune system
innate immunity nonspecific, 1st level of defense; physical and chemical barriers (skin, pH of gi tract, enzymes in tears)
monocyte macrophage arise from monocytes; migrate to tissues, phagocytize, release cytokines, present antigens; secretory products like hydrolytic enzymes, tnf-alpha, interleukins
cytokines chemical signals produced by wbc; regulate, coordinate immune system; inflammation regulation
natural killer cells granular lymphocytes, destroy tumor cells and virus-infected cells
adaptive immunity 2nd line of defense; slower to respond and dependent on innate immune system
toll-like receptors help activate immune response
acquired immunity specific/memory response
major histocompatibility complex (mhc) aka (hla) human leukocyte antigen
t cells cell-mediated immunity
b cells antibody-mediated immunity (humoral immunity)
cd4 cells helper t cells; damaged by hiv
cd8 cells cytotoxic t cell
antigen presenting cells (apc) macrophages and dendritic cells; present antigens to lymphocytes to activate t cells; derived from bone marrow precursors
plasma cells antigens activate a specific b cell; activated b cell becomes plasma cell that produces antibodies (immunoglobulins) (antibody-mediated or humoral immunity)
activated b cells also form memory cell; that has quicker and stronger response
immunoglobulins produced by b cells; bind to specific antigens
primary response first exposure to antigen, lag time before Ig levels inc, IgM first antibody
secondary response any exposure after first, amnetic response, IgG levels inc rapidly (memory cell response), antigen neutralized before disease signs and symptoms
IgD hypersensitivity reactions; attached to surface of b cells and in skin, gi, respiratory tract; bind to basophils and mast cells
IgM macroglobulin-largest Ig; found throughout bloodstream, present in early infection
IgG long-term immunity; most abundant Ig in bloodstream, present late in disease/recovery and long after, moves across maternal-fetal barrier
IgA protects mucous membranes of gi, gu, and pulmonary systems; found in saliva, secretions, breast milk, gi, tears
IgE produced in response to allergies and parasitic infections; found on mast cells in pulmonary and gi tracts, skin and mucous membranes
active acquired exposure to antigen thru illness or vaccination; immune system activated and memory cells produced
passive acquired individual receives premade antibodies; immediate immunity, but short-term; antibodies transferred in breast milk
vaccines specific formulation that contains a weakened, nondisease-producing pathogen; exposes body to antigen
vaccines stimulate immune response and produce memory cells w/o disease contraction
booster additional dose of vaccine to stimulate the immune system's antigenic memory
toxoid vaccine produced against toxin-producing bacteria (tetanus toxoid)
anergy panel test of immunocompetence where inject common antigens (mumps, candida) intradermally; patient should have positive skin reaction, lacks response may indicate immune deficiency
antibody titers antibody screening tests indicating presence and level of antibodies; can indicate immunity
allergy test skin test to measure reaction to allergen by scratching or injecting small amount of antigen into skin (IgE)
serology testing measures IgE levels in response to antigens
overreaction hypersensitivity and 4 types
underreaction immunodeficiency
primary immunodeficiency (congenital) present @ birth
secondary immunodeficiency (acquired) develops due to infection, chemotherapy, immunosuppressive drugs
type 1 hypersensitivity (immediate) allergy, atopic disorder; process: antigen (allergen) interacts with apc, b cells are activated and produce IgEs, IgEs bind to mast cells, cause degranulation, histamine induce allergy symptoms
degranulation release of histamine from mast cells
allergic rhinitis allergen causes release of histamines, prostaglandins, leukotrienes; mucous hypersecretion, bronchiole constriction, pale nasal mucosa, watery eyes, sneezing, rhinorrhea, cough, bronchospasm
most common food allergies milk, eggs, peanuts, wheat, barley, rye, oats, tree nuts, walnuts, almonds, pecans, fish, soy, shellfish
anaphylaxis severe, overwhelming allergic response (urticaria, bronchoconstriction, laryngeal edema, angioedema); death can occur, medical emergency
angioedema swelling of facial area
epipen (epinephrine) used to counteract response until medical help can be obtained
type 2 hypersensitivity (cytotoxic) Igs attack antigens on cell surface, antibody-mediated cell lysis results; blood transfusion reaction-hemolytic transfusion reaction
type 3 hypersensitivity (immune complex) antigen-antibody complex deposited in tissues; tissue damage results, may be systemic (lupus) or localized (rheumatoid arthritis)
type 4 hypersensitivity (delayed) t cell mediated, previous exposure to antigen primes t cells; t cell attack does not occur until days after initial exposure (delayed); mantoux test for tb; poison ivy or transplant rejection
autoimmune disorder attacks self cells, t cell or Ig-mediated (autoantibodies), organ-specific or systemic
molecular mimicry body's antigens resemble infectious agent, immune system mistakenly attacks body's cells (rheumatic fever)
systemic lupus erythematosus (sle) mulisystem disease; antinuclear antibodies present, antibody complexes deposited in tissues, chronic disease w remission and exacerbations
systemic lupus erythematosus shows skin rash (butterfly rash across cheeks), joint inflammation, kidney damage, vasculitis, raynaud's phenomenon
systemic lupus erythematosus people are genetically predisposed, environmental factors (ebv infection), hormonal component; diagnosis on history, physical exam, and lab results
ana elevated in 95% of lupus cases ana elevation not specific to lupus
rheumatoid arthritis (ra) chronic joint inflammation (affect multiple tissues)
rheumatoid arthritis risks genetic factors, environmental factors (infections), hormonal influence (women more likely to develop ra)
symptoms of ra symmetrical, tender, swollen joints in fingers, wrists, knees, and hips; painful stiff joints for 30+ mins
diagnosis of ra set of specific criteria (acr), rheumatoid fever, esr, c-rp elevation, swan neck, and boutonniere derformities
sarcoidosis chronic, multi-system disorder; accumulation of t cells, macrophages in organs; chronic inflammaation causes granulomas, in lung, skin, eyes; erythema nodosum: tender, erythematous nodules on anterior legs
diagnosis of sarcoidosis chest xray reveals bilateral hilar lymphadenopathy, no diagnostic blood tests; biopsy of sarcoid lesion
human immunodeficiency virus (hiv) virus that infects cd4 cells (t helper); 3 stages-->acute, chronic, aids
routes of hiv transmission sexual activity, semen and vaginal secretions, blood, transplacental, breast milk, organ transplants, saliva (in open mouth wounds)
high risk individuals for hiv participate in unsafe sex, gay sex, iv drug abusers
hiv-1 more common in us hiv-2 more common in w africa
retrovirus rna virus, reverse transcriptase: enzyme converts hiv rna into dina; virus gives genetic instruction to the host and host uses dna to make more viruses in body
hiv targets cells that express cd4 receptors and chemokine receptors, ccrs or cxcr4
ccrs receptor on surface of t cells, needed for hiv attachment to t cell
infected cd4 cells unable to carry out normal functions (adaptive immunity compromised)
acute retroviral syndrome of hiv occurs in first 28 days, flu like symptoms: fever, headache, fatigue, pharyngitis, gi symptoms, lymphadenopathy, arthralgias, and myalgias; asymptomatic early on
late-stage symptoms of hiv fever, night sweats, weight loss, opportunistic infections; high levels of antibodies
normal cd4 range 800-1200 cell/ml
<500 cd4 cells inc opportunistic infection risk
<200 cd4 cells lead to aids classification
diagnosis of hiv hiv rna assay (earliest detection): measures # viruses in bloodstream; inversion of cd4:cd8 ratio (1:2 in hiv);
seroconversion antibody negative to antibody positive; detectable antibodies (2 weeks-6 months); ELISA must be confirmed
most accurate measurement of immune system impairment cd4 levels when fall below 200 (aids)
complications of hiv opportunistic infections: pneumocystic pneumonia, tb; malignancies: kaposi sarcoma, non-hodgkins lymphoma; aids
kaposi sarcoma cancer lesion in soft tissues (bump)
kidney functions filtration, secretion, acid/base balance, blood pressure regulation, rbc formation, drug metabolism, hormone metabolism, vitamin d synthesis, and glucose homeostasis
kidneys receive 1/3 of cardiac output
glomerular filtration rate (gfr) renal blood filtered per unit of time, 90-120 ml/min; directly related to renal perfusion, dec renal perfusion=dec gfr
gfr peak @ 30 dec to 70ml/min @ 70
nephron functional unity of kidney
nephron functions filtration, reabsorption, and secretion
end product of nephrons urine
bowman's capsule and glomerulus form renal corpuscle
endothelium of glomerulus and capsule membrane contain filtration slits allow water and substrate to filter out water and substances from blood
glomerular capillaries specialized capillaries, blood enters thru afferent arteriole, leaves thru efferent arteriole; high hydrostatic pressure causes filtration of blood
proximal tubule segment following bowmans capsule, reabsorbs majority of filtrate
loop of henle begins to concentrate filtered fluid, urea
urea waste product enters loop of henle
distal tubule under influence of aldosterone, absorbs water and sodium
collecting ducts under influence of adh, additional water reabsorbed
glomerulus releases renin and erythropoietin
acid-base balance excrete/reabsorb H+ ion and bicarbonate as needed
waste elimination urea, uric acid, creatinine (Cr), drug metabolites
secretory function erythropoietin (epo) and renin
erythropoietin increases rbcs in response to hypoxia
renin released in response to low bp or perfusion; activate raas (renin-angiotensin-aldosterone)
vitamin d synthesis and calcium balance kidney activates vitamin d, important in calcium absorption
glucose homeostasis renal threshold to reabsorb glucose (bg of 180 mg/dl), kidneys degrade insulin, gluconeogenesis; can lead to glucose being pushed into urine (diuresis)
polydyspia very thirsty
polyphasia cannot stop eating
polyurea constant peeing
kindey dysfunction consequences insufficient filtration and waste buildup, unconcentrated urine, toxin build up:destruction of blood cells, confusion, excess renin secreted raising bp, dec erythropoietin (dec rbc), a/b unbalanced, excess K+ not secreted, dec vitamin d, dec ca absorption
kidneys are susceptible to ischemic injury
high pressure is required to push fluid thru kidneys and urinary system
nephrons are harmed by toxins
uropathy obstruction of urine flow; can cause fluid backup which damages renal pelvis
symptoms w kidney damage cva tenderness, hematura, proteinuria, tea-colored urine
costovertebral angle (cva) tenderness pain where kidneys are, hit on back causes lots of pain
ensephylopoly toxin build up
abdominal tenderness pressure; red/swollen/heat/pain/not functional
hematuria blood in urine, not filtering correctly; urine is pink or red, sign of renal calculi or infection
proteinuria microalbuminuria, protein in urine; looks foamy
tea-colored urine bilirubin (built up rbc) in urine; brown color
kidney stones from too much calcium in kidneys
oliguria low urine output <400ml per day
anuria no urine output (kidney failure)
diagnosis of urinalysis pH 4.6-8, specific gravity, uncontrolled diabetes, ketones, leukocyte esterase, nitrite, protein, bilirubin, urobilinogen, crystals (urolithiasis), casts
specific gravity measures particles in urine-electrolyes and osmolarity (1.005-1.030)
ketones fasting starvation or uncontrolled diabetes
leukocyte esterase (wbcs) and nitrite uti or asymptomatic bacteriuria
protein pos can indicate inflammation, htn, glomerular injury
bilirubin liver disorders, excess hemolysis
urobilinogen liver disease-none indicates liver not working
other diagnostics of urinalysis nephrotic syndrome, dehydration, vigorous exercise, diuretics, tubular necrosis, autoimmune disorders, pyelonephritis, other kidney diseases
urine culture reveals presence or absence of bacteria
clean-catch samples cultures w >100,000 cfu of one type of bacteria usually indicative of infection
samples collected w minimal contamination (catheter) 1,000-100,000 cfu; can be considered significant
urea composite of nitrogenous waste that needs to be excreted; waste product
azotemia increase BUN in blood
blood urea nitrogen (BUN) 6-24 mg/dl increased when dec gfr, dehydration, extremely muscular persons, high protein diet
uremia extremely high levels of urea and other nitrogenous wastes; worsening of chronic failure
creatinine product of muscle breakdown that is excreted completely; measures kidney filtration
high serum creatinine kidney dysfunction
creatine clearance used to assess gfr, collected by blood sample and 24 hr urine
decreased creatinine clearance decreased gfr and impaired renal function
serum creatinine is better measure of kidney function than bun
BUN good measure of dehydration, high protein intake, and high muscle breakdown
diagnosis of kidney dysfunction renal ultrasound, iv pyelography, ct scan, mri
urosepsis complication of uti w bacteremia
diuresis large unconcentrated urine outflow
neurogenic bladder spinal cord disorders
hydronephrosis urine back up into kidney
acute kidney injury (aki) or acute renal failure abrupt insult to the kidney: rapid dec kidney function (w intervention, normal function restored)
signs of aki azotemia, elevated cr, fluid retention
classifications of aki prerenal, intrarenal, postrenal
prerenal (most common) decreased blood flow and perfusion to kidney
intrarenal injury to kidney from medications or infections
postrenal obstruction of urine outflow from kidneys
prerenal dysfunction reduced cardiac output or severe hypovolemia (low blood vol), shock, large blood loss from body (hemorrhage from ischemia)
prolonged renal hypoperfusion acute tubular necrosis-damage to nephron tubule epithelial cells
atn cell slough off tubules-block lumen and urine formation; worsens injury (intrarenal); if not revered renal failure
intrarenal dysfunction trauma to kidney (pyelonephritis, autoimmune (lupus); infection of kidney (post-streptococcal glomerulonephritis); nephrotoxic drugs (nsaids, ace inhibitors, angiotensin-receptor blockers, statins, antibiotics)
postrenal dysfunction hydronephrosis (urine backup into kidney); example: kidney stone, prostate gland hyperplasia, neurogenic bladder
aki phases initial insult, oliguria, diuresis, recovery
initial insult prerenal, intrarenal, or postrenal condition that disrupts kidney function
oliguria low gfr, lack of urine output, fluid overload
diuresis large unconcentrated urine outflow; kidney is not concentrating urine properly
recovery healthy nephrons take over function of damaged nephrons; kidney function resumes
acute tubular necrosis (atn) ischemia and hypoxia damage to nephron, common cause of aki, can lead to renal failure
acute glomerulonephritis (agn) or nephritic syndrome triggers inflammation that damages the membranes of the glomerulus; autoimmune or post-streptococcal disorder; can progress to esrd; antigen-antibody reaction damages glomeruli leading to hyperpermeability
damaged glomeruli leads to protein loss, edema (periorbital), oliguria, hypervolemia, psgn: 7-21 days post strep; dark urine: rbcs
diagnosis of nephritic syndrome elevated serum Cr and BUN; low serum albuminia; urinalysis: protein, wbcs, blood; antibodies to streptococcal bacteria present
treatment of nephritic syndrome antibiotics, dietary modifications, diuretics
nephrotic syndrome glomerular damage resulting in proteinuria and edema; commonly caused by diabetes mellitus, amyloidosis, and lupus
nephrotic syndrome is massive albuminuria (facial edema), hematuria, htn, oliguria; hyperlipidemia=lipid synthesis by liver inc as liver inc albumin synthesis to compensate for urinary loss
treatment of nephrotic syndrome adequate liquid, dietary modification, may become renal failure
renal calculi stones (calculi) in kidneys; presentation depends on location; kidneys secrete stone-inhibitors
urolithiasis stone travels to ureter
cystolithiasis vesical calculi in bladder
risks for renal calculi genetics, diet, metabolic abnormalities, dehydration, excess ca intake, hyperparathyroidism, gout, hyperuricemia, immobility, uti, urinary stasis
calcium renal calculi most common kind; hypercalcemia
struvite renal calculi magnesium and ammonium phosphate; occurs in proteus uti; patients with spinal cord injuries more @ risk
uric acid renal calculi foods high in purines; gout
cystine renal calculi rare, disorder of cystine metabolism
symptoms of urolithiasis cva pain, abdominal pain, spasms of ureter; pain in waves lasting 20-60 mins; nausea, vomiting, fever, hematuria, pyuria, crystalluria, painful urination, writing to control pain, hydronephrosis
diagnosis of calculi hematuria and crystalluria, ultrasound, ct scan, collection of stone and stone analysis
treatment of calculi hydration greater than 3L/day, pain meds, diuretic, lithotripsy
pyelonephritis infection of renal pelvis; ascends into uti; stasis of urine plays role
factors affecting pyelonephritis obstructive uropathy, vesicoureteral reflux (anatomical abnormality), neurogenic bladder, urological instrumentation, pregnancy
symptoms of pyelonephritis fever, abdominal or cva tenderness, flank pain, nausea, vomiting, chills, dysuria, urinary frequency, microscopic hematuria, pyuria, leukocyte esterase test of urine
pyuria wbcs in urine
diagnosis of pyelonephritis urine cultures (e coli, s saprophyticus, p mirabilis); dipstick urinalysis (pyuria, + leukocyte esterase); contrast-enhanced helical/spiral computed tomography, ct scan (kidney, ureters, bladder), ultrasound
polycystic kidney disease (pkd) genetic disorder; kindey and other organs affected; cysts formation impair renal function; 6-8% of patients on dialysis in us
most common form of pkd autosomal dominant pkd (recessive exists)
pkd symptoms fluid-filled cysts in kidneys; pain, renal calculi, cva, inc bp (if cysts place pressure on kidney blood vessels, activating raas)
diagnosis of pkd ultrasound and ct scan
chronic renal failure (crf) irreversible and progressive w gradual onset; 90-95% of nephrons affected; progresses to esrd; hemodialysis or kidney transplant needed; dm, htn, glomerulonephritis, and pkd are leading causes
stage 1 of crf kidney damage w normal or inc gfr (>90ml/min)
stage 2 of crf mild reduction in gfr (60-89ml/min)
stage 3 of crf moderate reduction in grf (30-59ml/min); symptoms become apparent; serum cr and bun inc
stage 4 of crf severe reduction in gfr (15-29 ml/min)
stage 5 of crf kidney failure (grf <15ml/min); transplant or dialysis needed
complications of crf uremic encephalopathy, proteinuria, hypoalbuminemia, edema, fluid overload, oliguria, electrolyte imbalances, hemolysis, thrombocytopenia, anemia, dec vitamin d, htn, metabolic acidosis, hyperkalemia, hypocalcemia, hyperphosphatemia, hyperparathyroidism
crf diagnosis cbc, bun, cr serum levels, urinalysis, albumin levels; renal imaging studies
crf treatment fluid and electrolyte management, along w bp management; gfr <10-20ml/min- dialysis, kidney transplant
urological disorders affect ureter, bladder, urethra, and prostate
obstructive uropathy (blockage) leads to hydronephrosis fluid buildup in kidneys
lower utis more common in women
urolithiasis stones
adequate urine volume and unimpeded urine flow essential for kidney health
detrusor major muscle in bladder
bladder is innervated by sympathetic-relax detrusor, tighten internal sphincter; parasympathetic-contract detrusor, relax internal sphincter
bladder hold 300-400ml urine
micturition reflux (urination) stretch of bladder walls send signals to spinal cord, activation of parasympathetic system, cerebral cortex: voluntary control of voiding
prolonged obstruction results in inc hydrostatic pressure in nephrons dec gfr
hydronephrosis dilation of renal calyces and pelvis due to obstruction; acute is reversible
hydroureter dilation of ureter due to obstruction
in children dilation of structures can be from anatomic abnormalities like vesicoureteral reflux, urethral stricture, stenosis
lower utis most commonly caused by e coli, originating from bowel; proteus, pseudomonas, and klebsiella; proteus more common w catheterization or urinary instrumentation
healthy urinary tract only has bacteria in urethral opening
stagnant urine inc infection risk for lower utis
female risks for lower utis improper perineal hygiene, tight/restrictive clothing, chronic dehydration, diabetes, use of irritating bath products, sex, urinary catheterization, use of contraceptive diaphragms and spermicides, pregnancy
male risks for lower utis chronic dehydration, diabetes, bph which obstructs free flow of urine, bladder cancer, urinary catheterization
hospital-acquired uti catheterization, multi-drug resistant pathogens, polymicrobial infection
symptoms of lower utis inc frequency, dysuria, and urgency, hematuria, fever not present
diagnosis of lower utis urinalysis-rbcs, +leukocyte esterase (wbcs), nitrates (bacteria); urine culture->100,000 cfu
urosepsis serious complication of uti, bacteremia with bacterial endotoxins; acute, severe illness (fever, chills, confusion, disorientation, hypotension); elder, catheterized, immunocompromised @ risk
asymptomatic bacteriuria (asb) 2 consecutive urine cultures >100,000 cfu bacteria; patient lacks uti symptoms; treatment w antibiotics doesnt help outcomes
stress incontinence most common, women more @ risk due to loss of muscle support in pelvic floor; childbirth, abdominopelvic surgery, low estrogen (menopause) contributes to weakness of pelvic floor
overactive bladdre (oab) detrusor muscle overactivity
overflow incontinence chronic overdistention and urinary retention in bladder, detrusor muscle loses strength and elasticity, bph most frequent cause in men
functional incontinence inability to hold urine (stroke, delirium)
risk factors urinary incontinence inc age, pregnancy, childbirth, obesity, diabetes, stroke, neurological impairment, prostate disease and its treatments
diagnosis of urinary incontinence x ray of kidney, ureter, bladder; ultrasound, ct scan, ivp, urodynamic testing, cystoscopy may be necessary, measurement of postvoid residual volume in bladder, simple urinary cough test, cotton swab test
simple urinary cough test patient asked to forcefully cough with a full bladder in standing position
cotton swab test assesses mobility and strength of bladder sphincter, sterile cotton swab lubricated with lidocaine and inserted transurethrally into bladder, patient asked to cough, angle of cotton swab can indicate stress incontinence
cystitis bladder inflammation
stroke 5th leading cause of death in us; results in paralysis on one side of body; risk for afr amer is greater
central nervous system brain and spinal cord
peripheral nervous system cranial and spinal nerves
spinal cord motor neurons descend/sensory neurons ascend
upper neurons within brain
lower neurons spinal cord
corticospinal tract upper neurons that descend into spinal cord
contralateral cross over (80%)
ipsilateral remain on same side (20%)
decussation brainstem area of crossover
cerebral injury presentation often on opposite side of body
cerebrum upper most region of brain, right and left hemisphere, corpus callosum (connection)
diencephalon thalamus and hypothalamus, relays sensory info and controls many autonomic functions
categorical hemisphere language, sequential-analytic; L hemisphere in most
representational hemisphere face recognition, music, visual-spatial; R hemisphere in most
aphasia difficult to speak or understand language
broca's area speak language; expressive aphasia
wernicke's area comprehend language; receptive aphasia
frontal lobe reasoning (judgement), behavior (emotions), thinking initiation, movement, speaking, memory
parietal lobe understanding spatial relationships, knowing right from left, sensation, reading
temporal lobe understanding language, behavior, memory, hearing
occipital lobe vision, color blindness
brainstem breathing, blood pressure, heartbeat, alertness/sleep
cerebellum balance, coordination, fine muscle control
brainstem cranial nerves originate
midbrain vision, hearing, movement
pons consciousness and sleep
medulla oblongata vital body functions
cerebellum coordinated movement and equilibrium
ataxic gait uncoordinated walking
internal carotid serves brain's anterior and middle cerebral arteries
anterior cerebral artery frontal lobe
middle cerebral artery lateral cortex, 80% of brain's tissue; most strokes involve branch of this artery
R/L vertebral arteries feed posterior brain
circle of willis base of brain, provides collateral circulation, formed by posterior cerebral artery and internal carotid; common site for aneurysms (weakness in arterial wall)
cranial nerves 12 pairs, 1-12; either motor, sensory or both; brain injury, tumor, or stroke can disrupt cranial nerve functioning; cranial nerve abnormalities may be a sign of inc intracranial pressure
brain most energy-consuming organism, 20% of oxygen, brain cells not capable of anaerobic metabolism, brain cells die 5-6 mins, irreversible damage may occur
there must be a continuous supply of oxygen and glucose for cell metabolism
hypoglycemia and hypoxia affect brain functioning
2 types of stroke ischemic or hemorrhagic
ischemic stroke (85%) thrombus or embolus, leads to cerebral artery; most common in internal carotid and middle cerebral artery
hemorrhagic stroke (15%) rupture of cerebral artery; caused by htn, aneurysm rupture (most common in circle of willis), subarachnoid hemorrhage (arterial branch in subarachnoid space ruptures)
transient ischemic attack (tia) ischemic injury "mini stroke"; disruption of cerebral circulation lasting less than 24 hrs; no permanent injury but can warn of future attacks
causes of ischemic stroke cerebral arteriosclerosis, carotid stenosis, atrial fibrillation
atrial fibrillation stasis of blood leads to clot formation
cerebral ischemia develops gradually if completely occluded: neurons in core area of ischemia suffer irreversible infarction within minutes
ischemic penumbra perimeter of ischemic zone; less perfusion but not irreversible damage; rapid reperfusion is critical to recover cells
cerebral edema may develop in area causing further damage
glutamate toxicity excritatory neurotransmitter; occurs from failure of cellular ion pumps; inc in glutamate extracellularly, Ca influx intracellularly (cell death)
transient ischemic attacks are temporary and resolve 20-25% of tias progress to stroke; neurological changes may go unnoticed by patient (observable by bystanders, resolved by time medical staff comes, interview and observation key)
lacunar infarct small infarcts in brain due to occlusion of tiny blood vessels
tia cause needs to be identified and corrected usually blocked carotid arteries and cerebral artieries from atherosclerotic plaques
hemorrhagic stroke pathophysiology blood flows into brain, compresses and displaces brain tissue, blood causes vasospasm of adjacent blood vessels, blood released is toxic to surrounding cells, anoxic encephalopathy, cerebral edema, cushing's triad, hematoma and clot form
anoxic encephalopathy lack of oxygen delivery causes decreased level of consciousness
cerebral edema may occur w hemorrhagic stroke, putting pressure on brain tissues pressure on brainstem causes alteration in HR, breathing, pupil dilation
cushing's triad: pressure on brainstem bradypnea (irregular respirations), bradycardia, hypertension
if hemorrhage is large, hematoma and clot form; may expand in 24 hrs w worsening symptoms immune response and scar tissue form
risks for stroke htn, hyperlipidemia, diabetes, smoking, obesity, lack of exercise, atrial fibrillation, oral contraceptives, excess alcohol, fam history, age 65+, male, afr amer, sickle cell disease, tia, avm
signs of stroke middle cerebral artery most common stroke location: speech, motor, sensory deficits; neurological deficits on one side of body: slurred speech, loss of gag reflex, facial droop, hempiaresis, hemiplegia, loss of sensation/vision, disorientation, confusion
FAST facial droop, arm weakness, speech difficulty, time to call 911
subarachnoid hemorrhage (SAH) presents differently than most hemorrhagic strokes; sudden onset (worst headache ever), vomiting, photophobia, seizures, dec LOC, neuro deficits, poor prognosis
vertebrobasilar insufficiency (vbi) ischemia of vertebrobasilar circulation from compression of vertebral or basilar arteries (space bw C1 and occiput); dizziness, vertigo, headache; cracking neck
any sudden changes in neurological function should be assessed no reliable clinical presentation to distinguish bw ischemic or hemorrhagic stroke
1 sided symptoms and signs slurring speech, facial droop, hemiparalysis
diagnosis of strokes ct scans w/o contrast for acute phase (identify or exclude hemorrhagic stroke); ct scan w dye may allow better visualization for ischemia; magnetic resonance angiography (mra); transcranial doppler; national institutes of health stroke scale (nihss)
magnetic resonance angiography can distinguish bw ischemic and hemorrhagic stroke
national institutes of health stroke scale (nihss) neurological exam w 11 categories, quantity deficits attributed to stroke (>25 severe impairment), monitor progress
treatment for ischemic strokes iv thrombolyis, Rt-PA: recomibinant tissue-type plasminogen activator (clot buster); surgical thrombectomy for eligible candidates, rehabilitation (1st 4 weeks post-stroke especially important to regain function)
treatment of hemorrhagic strokes hemodynamic stabilization, intubation and bp reduction, manage cerebral edema, surgical treatment
peripheral nervous system nerves somatic nerves (motor/sensory) & autonomic nervous system
neurons conduct electrical signals
glial cells support cells
neurotransmitters released into synapses of nerves causing next neuron to fire or be stimulated; can activate or inhibit functions
examples of neurotransmitters GABA, epinephrine, norepinephrine, acetylcholine, dopamine, endorphins, serotonin
nerve conduction movement of ions
depolarization sodium influx-generates action potential
repolarization potassium efflux-return to rest phase
resting membrane potential polarization of cell
refractory period rest period where cell cannot repeat action potential
myelin productive sheath around axon of some neruons
insulator myelin sheath contains lipids, "white matter", helps conduct electrical signal more quickly
some disorders cause degeneration of myelin multiple sclerosis, amyotrophic lateral sclerosis
myelin regrowth may be possible for some time
assessment of neurological system may be difficult to diagnose initially, degenerative disorders progress and be apparent later; speech, demeanor, emotional state; cognitive function; head trauma; upper/lower motor strength; reflexes, sensation, examine gait, cranial nerve assessment
reflexes babinski-negative-toes flex inward; positive toes flare out (upper motor neuron disorder)
hemiparesis half of body is weak/partial paralysis
hemiplegia half body paralyzed
upper motor neuron (UMN) problem in brain's area of motor control, responsible for voluntary movement and modulating involuntary movement, damage causes spasticity
lower motor neuron (LMN) problem at the region where motor nerves exit the spinal cord, prevent excessive muscle movement, damage causes flaccidity
epilepsy chronic neurological disorder with recurrent seizures; manifestations depend on area affected
seizure sudden, abnormal, disorderly discharge of neurons within the brain
diagnosis of epilepsy 2 unprovoked seizures at least 24 hrs apart
epileptogenesis transformation of normal neuronal region into hyperexcitable area
focal seizures localized within 1 cerebral hemisphere
initiation phase of seizure high frequency action potentials and hyper synchronization (spike on eeg)
generalized seizure involve both cerebral hemispheres
3 types of seizures focal, generalized, unknown
seizures cause motor, nonmotor, or both symptoms
clonic sustained rhythmical jerking
atonic weak or limp muscles
tonic rigid or tense muscles
myoclonus muscle twitching
epileptic spasms repeated flexion and extension of the whole body
nonmotor symptom absence seizures, staring spells w no movement
aura sensation before a seizure
ictal period time of seizure
postictal after seizure complete, person may be tired, confused, nauseated, may have amnesia
interictal if multiple seizures occur in short time, the time bw seizures
seizure etiology head trauma (most common), stroke (elderly), brain neoplasmss, congenital malformation, degenerative brain disorders (alzheimers), environmental stimuli (blinking lights), genetic predisposition, infections, hypoglycemia, hyponatremia, respiratoryalkalosi
seizure etiology 2 perinatal injury (hypoxia), withdrawal from alcohol or sedative-hypnotic drugs
diagnosis of seizures cbc, serum chemistry, brain imaging studies (mri, ct), and eeg (sleep deprivation inc sensitivity)
emergency seizure care during-protect patient from injury, move objects out of way, do not physically restrain, do not put anything in his/her mouth; after-place patient on left side and turn head, any emesis or oral secretions will drain out of mouth and will not be inhaled
primary headaches arise independently of any other medical illness or traumatic cause, tension-type, migraine, and tri-geminal autonomic cephalgia
secondary headaches caused by another primary condition, head injury, vascular problems, medication side effects, sinus disease, and tumors
tension type headache (tth) most common primary headache (infrequent, frequent, chronic), bilateral pain with mild to moderate pressure, doesnt worsen w physical activity, no vomiting/nausea, iinc cervical and pericranial muscle activity; diagnosis: clinical finding
migraine headache periodic, throbbing headaches, altered perceptions, nausea, severe pain, photophobia, phonophobia, worsens w movements, aura may precede headache, 75% migraine sufferers are women
migraine headache phases prodrome (neural hyperexcitability), aura (cortical spreading depression occurs), pain (trigeminovascular complex activation), postdrome (sensitization of trigeminovascular complex persists)
migraine pathophysiology serotonin dec and calcitonin gene-related peptide (crgp) inc thought to play a role (crgp=vasodilator)
migraine triggers stress, hormone shifts, excessive exercise, lack of sleep, fatigue, hypoglycemia, certain foods
sinus headache caused by sinus infection, fever and rhinorrhea present, pain worsens when patient leans over (facial areas over frontal and maxillary sinuses may be tender), transilumination of sinuses may show nontransparency, treatment-antibiotics/nasal decongestants
brain tumor headaches 50% of those w brain tumor will experience headache
headache is dull and constant, may throb usually bifrontal, with worse pain on same side as tumor, generalized head pain may occur w inc intracranial pressure
papilledema and cranial nerve may be present in brain tumor headache
worsening of headache with change in body position any maneuver that raises intrathoracic pressure or intracranial pressure
parkinsons disease men and women equally affected, progressive loss of dopamine-producing cells in substantia nigra; movements such as posure, standing, walking and writing affected
acetylcholine stimulates muscle movement, while dopamine has an inhibitory effect dopamine depletion imbalance causes unopposed acetylcholine (tremors, uncoordinated movements)
accumulation of alpha-synucle abnormal protein found in structures called lewy bodies in brainstem, spinal cord, and regions of cortex
parkinsons can affect ans causing nonmotor symptoms
symptoms of parkinsons begin unilaterally, progressively to both sides, classic triad, postural instability, nonmotor, neuropsychiatric
classic triad of parkinsons bradykinesia (slow movement), resting tremor (pill-rolling), muscle rigidity (cogwheel, ratchet movement)
diagnosis of parkinsons TRAP (tremor at rest, rigidity, akinesia (bradykinesia), postural/gait instability)
amyotrophic lateral sclerosis (als) lou gehrigs disease, progressive loss umn and lmn: painless muscle weakness and atrophy, sensory neurons and cognitive function, eventually respiratory failure (mechanical ventilation needed)
als signs/symptoms muscle weakness, speech changes, dysphagia, muscle spasticity, positive babinski reflex, diaphragm affected
multiple sclerosis chronic demyelinating disorder, affects brain, spinal cord, and optic nerves; remissions and exacerbations (damage heals during remission)
multiple sclerosis risks genetic predisposition, viral process, trauma, female, northern european descent, living in cooler climates
both sensory and motor neurons affected t cell mediated attack of myelin
relapse and remission in most forms multiple sclerosis
symptoms of multiple sclerosis weakness, numbness, balance problems, blurred vision; dysphagia, hemiparesis, paraparesis
cognitive functioning recent memory, abstract reasoning, attention can be affected
multiple sclerosis affective symptoms depression
multiple sclerosis diagnosis lesions of demyelination, mcdonald criteria (mri evidence and patient symptoms), blood work to rule out other conditions w neurological presentation (lyme disease, syphilis), csf analysis
guillain-barré syndrome (gbs) postinfections disease, acute inflammatory demyelination, weakness varies from mild weakness to complete paralysis, including respiratory muscles (recovery is steady over weeks and months)
myasthenia gravis (mg) autoimmune disease (attack of ach receptors), diagnosis (ach receptor antibodies), muscle weakness and fatigue, extraocular muscles often affected first ptosis; b and t cell mediated, thymus involved, 70% of patients with mg have thymus gland hyperplasia
myasthenia gravis presents in 2 ways ocular form: often patients first present with ocular changes; vs general form
flunctuating skeletal muscle weakness is cardinal feature true muscle fatigue, not a sense of tiredness, dec contractile force w repetitive motions, blinking, walking, talking, chewing, swallowing and respiratory function may be affected
myasthenia gravis extras rest improves muscle function, weakness severe enough to cause respiratory failure leading to mechanical ventilation, aspiration and respiratory failure cause death in severe mg
diagnosis of myasthenia gravis edrophonium testing (acetylcholinesterone inhibitor), allows more ach to remain in the synapses for a longer period of time, 30-45 secs after administration, improved muscle contraction
traumatic brain injury (tbi) sudden, physical damage to brain, closed or penetrating injury, concussion (ex), falls most common cause, males affected more than females
spinal cord injury (sci) damage results in loss of mobility or sensation, even if cord remains intact there is a loss of nerve injury below the injury
intracranial pressure (icp) pressure inside the skull, brain tissue and csf; normal (5-15 mm Hg (supine), icp inc w changes in volume to any one of the components; compensation (dec vol of other components, monroe-kellie hypothesis), inc icp after tbi related to inc mortality
supine laying down
level of consciousness (loc) self-awareness and reaction to environment, content of consciousness (cognitive function-cerebral cortex), consciousness not located in one region of brain (upper brainstem, reticular activating system, cerebral hemisphere)
alertness highest loc
lethargy individual sleepy but can be aroused easily
obtunded or stuporous difficult to arouse state, with little or no interaction with the environment
coma lowest loc, individual has no interaction with the environment
signs of inc intracranial pressure dec level of consciousness, pupillary dilation, headache, vomiting, papilledema, inc bp; crushing's triad-late signs (htn (widened pulse pressure), bradycardia, abnormal respiratory pattern)
tbi mechanisms of injury blunt trauma, acceleration-deceleration (head stops moving, but brain continues to move forward (stretching and shearing of neurons), coup-ccontrecoup injury (brain strikes one side of skull, rebounds, and strikes other side)
penetrating injury skull is fractured; blast injury
cerebral perfusion pressure (cpp) depends on mean arterial pressure and icp; cpp=map-icp
pressure autoregulation brain maintains normal cerebral blood flow w cpp ranging 50-150 mm Hg; vasodilatory cascade (dec cpp causes vasodilation to maintain flow); if pressure autoregulation disrupted, cerebral blood flow and icp altered;<50 cpp=loss of perfusion to brain tissue
mechanisms that inc icp vasogenic cerebral edema (shearing stress), cytotoxic cerebral edema (reduced oxygen), compression of jugular vein w tracheostomy ties or tight cervical collars may reduce venous flow from brain, inc icp
dec icp external drainage of csf via catheter, lower bp, hypertonic iv, low co2 (vasoconstrict cerebral arteries), removing brain tissue (lobectomy), decompressive craniectomy
brain death irreversible end of brain activity, coma, absence of brainstem reflexes, apnea (vital centers of brainstem disrupted) (brainstem reflexes compromised)
brain death may result from inc icp causing brain herniation transtentorial (uncal) herniation=temporal lobe (uncus) focused thru the tentorial notch compressing brain tissue
assessment of tbi examine for head trauma,neurological exam:loc, mental status, cranial nerve status, motor/sensory status, deep tendon reflex; duration of unconsciousness, post-traumatic amnesia (pta); consciousness/unconsciousness (eye opening to stimulation, not in coma
glasgow coma scale (gcs) assess the severity of brain injury, rating 3 areas (eye opening, verbal response, motor response); lowest gcs 3, highest 15, single gcs score cannot determine severity (use as series of scores, compare over time)
coma and posturing 1/2 rigid positions: decorticate or decerebrate
decorticate flexed arms, clenched fists, rigid legs; corticospinal tract damage
decerebrate arms held straight outward with toes pointed downward; upper brainstem damage
tbi diagnosis severity-mild/minor gcs 13-15, moderate gcs 9-12, severe gcs <9; ct scans-test of choice, demonstrates acute bleeding & pressure on vital structures; ct angiography-uses dye to observe vessels; mri-deeper brain structures: eeg
diffuse axonal injury (dai) common tbi, widespread damage to brain tissue, immediate loss of consciousness, most remain in coma; difficult to detect on imaging studies, mri may be used
major cause of unconsciousness and persistent coma after head trauma with dai w coup-contrecoup injury, diffuse swelling on neuronal axons, hemorrhage, or laceration corpus callosum, Ca entry into damaged axons activates proteases
concussion mild traumatic brain injury (mtbi), traumatic force causes disruption in brain function (may/not involve loss of consciousness); cease sporting activity until evaluation and assessment
types of concussion simple, complex
simple concussion resolve wo complication, may take up to 10 days
complex concussion symptoms may persist for longer, longer loss of consciousness (>1 min)
pathology of concussion direct blow to head, face, neck, or traumatic force transmitted to the head; multiple concussions have cumulative effect; glutamate released from cells, toxic to neurons; overstimulation of neurons and neuronal swelling
hort-term neurological dysfunction that resolves spontaneously neuropathological functional changes, but no structural changes, may or may not involve loss of consciousness, grossly normal structural neuroimaging studies
during concussion patient may state seeing stars, dazed, confused, headache, dizzy
concussions may have retrograde and antegrade amnesia, post concussion syndrome (pcs): symptoms longer than 3 weeks may be present
concussion diagnosis rule out cervical spine injury, epidural hematoma, subdural hematoma, subarachnoid hemorrhage; neurological examination; american association of neurology (concussion: grade 1, grade 2, grade 3); signs and symptoms evolve over time, ct scan
red flags of concussions anticoagulation use, alcohol/drug intoxication, neurological deficits, unequal pupils, persistent vomiting, seizure, droway w difficult arousal, headache that worsens, slurred speech, neck pain, weak/numb in legs/arms, change in loc, inc confusion
cerebral contusion bruise of brain tissue, scattered areas of bleeding on brain surface, undersurface frontal and temporal lobes, result from coup-contrecoup injury or penetrating wound; cerebral edema around contusion 48-72 hrs (inc icp/inc risk brain herniation)
signs/symptoms cerebral contusion severe headache, dizziness, vomiting, inc size of one pupil, sudden weakness in arm/leg, agitated/restless, memory loss, medical emergency (dec hr, dec respirations, htn, cannot be awakened)
cerebral contusion diagnosis ct scan, mri (greater sensitivity for cerebral edema), skull xray, delayed enlargement of brain contusion most common cause of clinical deterioration, periodic neurological assessment
head trauma/intracranial bleeds can cause 3 types of intracranial bleeds: epidural hematoma (edh), subdural hematoma (sdh), subarachnoid hemorrhage (sah); present differently, treated differently
epidural hematoma most serious complication of head injury, bleed in space below skull (caused by skull bone fracture lacerating middle meningeal artery; voluminous arterial bleeding); midline shift of brain can be viewed on imaging studies w/in hour of injury
epidural hematoma 2 injury leads to dec loc, followed by lucid period, and rapid deterioration, recognition of edh, presents w severe headache, vomiting, seizure, pupil distortion, cushing's triad; ct scan, skull xray, neurosurgical emergency: surgical evacuation of hematoma
subdural hematoma (sdh) bleeding in space below the dura mater; usually due to tearing of bridging veins in subdural space, most common type of traumatic intracranial hematoma, slow bleeding, but blood can accumulate over time
acute sdh within 72 hrs after head injury
subacute sdh take up to 7 days
neurological deficits do not usually occur until substantial bleeding repeat follow-up neurological exams needed
coagulation profiles anticoagulants, alcohol abuse
sdh ct scan and skull xray, large acute sdh require craniotomy to evacuate blood; small sdh may be slowly reabsorbed by brain
traumatic subarachnoid hemorrhage one of most common head injuries, tearing of cerebral and meningeal vessels w/in subarachnoid space, post-traumatic cerebral vasospasm in response to blood
aneurysmal subarachnoid hemorrhage weakened area of vessel, may rupture; berry aneurysm, in 50% of cases, symptoms precede rupture, thunderclap headache (rapid decline)
subarachnoid hemorrhage rupture of artery causes blood to fill subarachnoid space, blood irritates tissues and puts pressure on brain, sah can cause obstructive hydrocephalus, pressure may cause brain hernation; rule
subarachnoid hemorrhage assessment ottawa subarachnoid hemorrhage
subarachnoid hemorrhage diagnosis ct scan wo contrast
skull fracture common sites temporal bone-most common, orbital fossa, base of skull, foramen magnum
3 types of skull fractures may or may not involve injury to brain linear: most common, does not affect brain tissues; depressed: often open fracture; basilar: base of skull
basilar skull fractures occur along middle fossa, may involve brain injury; battle's sign: brusing on mastoid process behind the ear on affected side; csf lek from ear (csf ororrhea) or nose (csf rhinorrhea); loss of csf: ha, n/v, and dizziness
frontal fossa fractures can result in periorbital ecchymosis, reffered to as racoon eyes, edema, and csf rhinorrhea
diagnosis of skull fractures x ray of head, ct scan, neurological examination
csf skull fracture rhinorrhea or otorrhea, test for beta-2-transferrin and glucose-diagnostic for csf
spinal cord injury (sci) compression, stretching, or laceration of spinal cord following trauma
quadriplegia (tetraplegia) most common, paralysis of all 4 extremities
paraplegia 2nd most common, paralysis of lower extremities
mortality rates highest first year post sci
spinal cord injury surrounded by meninges and csf; conus medullaris (distal end), cauda equina syndrome (spinal nerves at end of spinal cord); ascending (sensory tracts); descending (motor) tracts
primary injury sci can led to hemorrhage and neuronal cell death
secondary injury sci due to ischemia form primary injury
sci worsen damage over hours to weeks, inflammation and scarring; fluid-filled cysts form
sci types of injury hyperflexion, rotational (unstable), hyperextension, axial loading (vertebral compression) and penetrating injuries
diagnosis of sci xray of spinal column, ct scan, mri, neurological assessment, abcs take precedence, stabilize spine and immobilization
areflexia results from primary injury, flaccid muscles, paralysis, lack of sensation below injury, bowel and bladder dysfunction; loss of anal reflex or bulbocavernosus reflex; autonomic function disrupted
spinal shock cannot assess extent of injury until spinal shock resolves, may take days to weeks (indicated by return of anal reflex and bulbocavernosus relex)
bulbocavernosus reflex contraction of anal sphincter w squeexing of glans penis or tugging on a foley catheter; indicates intact s1, s2, s3 nerves; in spinal shock, reflex absent
neurogenic shock occurs in patients w injuries at t6 and above; abnormal sns signaling; lack of bp, hr, vasoconstriction regulation
neurogenic sci about t6, disrupts sns, different from spinal shock; loss of ability to secrete norepinephrine when needed
neurogenic shock is unable to compensate for any decrease in bp blood pools in extremities from los of venules return and decreased co and bp
clinician should be aware that tachycardia may not be present w falling bp different from hypovolemic shock
stabilize pt. hemodynamically and monitor bp and ecg continuously
complete sci loss of all voluntary motor and sensory function below the level of injury
incomplete sci some motor or sensory function below the injury can remain intact; central cord syndrome, anterior spinal artery syndrome, brown-sequard syndrome, horner's syndrome, cous medullaris syndrome, cauda equina syndrome
c1-c3 unable to breath without respirator, loss of bowel and bladder control, unable to move arms and legs
c4-c7 severe weakness in arms w no motor function or sensation in legs, loss of bowel and bladder control truncal instability
thoracic spine paralysis in legs but arms can still function, truncal instability, loss of bowel and bladder control
lumbar sacral loss of bowel and bladder control, upper body strength and sensation normal, motor weakness or paralysis and sensory loss in hips and legs
complication of sci syringomyelia (fluid-filled cysts), neuropathic joint anthropathy (slow destruction of joints that occur over years), spasticity, cardiovascular and respiratory complications, anatomic dysreflexia, secondary immunodeficiency, bladder/bowel dysfunction
complications of sci 2 pressure injury, neurogenic heterotopic ossification, neuropathic pain (hyperalgesia, allodynnia, paresthesia)
Created by: cat9210
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