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Oncology Nursing
Question | Answer |
---|---|
A group of diseases characterized by uncontrolled or abnormal cell proliferation | Cancer defined |
Cell division in a part of a body that divides without control | Cancer defined |
What is a neoplasm? | neo=new; plasm=tumor |
Oncology | The study of Tumors |
Cancerous neoplasm | Malignant tumor |
Benign neoplasm | Does not spread to other parts of the body |
Wart | Benign neoplasm |
Hyperplasia | Growth that causes tissue to increase in size by increasing THE NUMBER OF CELLS |
Metaplasia | Transformation of cells from a normal to an abnormal state. |
Dysplasia | Dysplasia (from Greek, roughly: 'bad form') is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. |
Undifferentiated cells | Cells which are not well developed; have a tendency to multiply very quickly, and do not resemble healthy cells. |
Anaplastic | without shape or differentiation,small and round |
Aneuploid | More or less than the normal number of chromosomes |
Apoptosis | The finite life span of normal cells; "programmed cell death" |
Carcinogenesis | The transformation of a normal cell into a cancer cell |
doubling time | The amount of time it takes for a tumor to doble in size by mitotic cell divisions |
euploid | The normal chromosome number |
fibronectin | A large, extracellular, transformation-sensitive cell-surface protein present on normal cells that allows normal cells to adhere tightly together |
Gene expression | The activation, or "turning on" of a specific gene to the extent that it synthesizes a specific protein that influences the activity of a cell or group of cells. |
Gene suppression | The deactivation or "turning off" of a specific gene so that it is silent and does not synthesize a protein |
Generation time | The period of time necessary for once cell to enter and complete one round of cell division by mitosis |
initiation | the damage of a normal cell's DNA by a carcinogen |
Latency | The period of time between when a carcinogenic agent or substance damaged the DNA of a normal cell (initiated it) and when an overt cancer is present |
metastasis | Invasive growth of cancer cells from the original tumor into distant areas |
mitosis | Cell division by exact duplication |
morphology | apperance or shape |
multipotent | An undifferentiated cell that has multiple potentials for maturation and differentiation |
oncogene | A developmental gene (proto-oncogene) expressed at an inappropriate time, capable of transforming a normal cell into a cancer cell |
ploidy | The chromosome content of a cell |
Aneuploid ploidy | The chromosome content of a cell that is greater or lesser than the normal chromosome number for the species |
Diploid (euploid) ploidy | The normal chromosome content of a cell for the species (e.g., human cells have 46 chromosomes [23pairs] per cell) |
primary tumor | A tumor formed in a specific tissue as a result of a carcinogenic agent or event |
promotion | Enchancement of cell division in a cell initated by a carcinogen |
proto-oncogene | A developmental gene expressed during early embryonic development |
secondary tumor | A tumor formed as a result of breaking off from a primary tumor and spreading to distant sites (metastasis) |
suppressor gene | A gene that suppresses the expression of an oncogene |
transformation | the changing of a normal cell into a cancer cell by a carcinogenic agent or event |
Characteristics of Normal cells | *have limited cell division*undergo apoptosis*specific morphology*small nuclear-cytoplasmic ratio*Perform specific differentiated functions |
Characteristics of Normal cells | *Adhere tightly together*Nonmigratory*Grow in an orderly and well-regulated manner*Contact inhibited*Euploid |
Cell cycle: G 0 | Cell actively carries out function, but doesn't divide |
Cell cycle: G0 | Suppressor genes(proteins) control whether cells enter and complete the cell cycle |
Cell cycle: G1 | Cell gets ready for division by taking on extra nutrients, making more energy, growing extra membrane, and increasing amount of ctoplasm |
Cell cycle: S | The cell doubles its DNA content through DNA synthesis |
Cell cycle: G2 | Cell makes important proteins that will be used in cell division and normal physiologic function after cell division |
Cell cycle: M | (mitosis) The phase in which the single cell splits apart into two cells. |
Charateristic of Early Embryonic Cells | Rapid and continuous cell division |
Charateristic of Early Embryonic Cells | Do not respond to signals for apoptosis |
Characteristic of Early Embryonic Cells | Show anaplastic morphology |
Characteristic of Early Embryonic Cells | Have a large nuclear-cytoplasmic ratio |
Characteristic of Early Embryonic Cells | Perform no specific functions |
Characteristic of Early Embryonic Cells | Adhere loosely together |
Characteristic of Early Embryonic Cells | Able to migrate |
Characteristic of Early Embryonic Cells | Are not contact inhibited |
Characteristic of Early Embryonic Cells | Are Euploid |
Characteristic of Early Embryonic Cells | Commitment cells |
Characteristic of Benign Tumor Cells | have continuous or inappropriate cell growth |
Characteristic of Benign Tumor Cells | Show specific parent cell morphology |
Characteristic of Benign Tumor Cells | Have a small nuclear-cytoplasmic ratio |
Characteristic of Benign Tumor Cells | Perform specific differentiated functions (as parent cells do) |
Characteristic of Benign Tumor Cells | Adhere tightly together |
Characteristic of Benign Tumor Cells | Are nonmigratory |
Characteristic of Benign Tumor Cells | Grow in an orderly manner |
Characteristic of Benign Tumor Cells | Are euploid |