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LSC PD Drugs

LSC Nursing

QuestionAnswer
Dopamine Agonists mimic dopamine, most effective in 1st 3-5yrs, include apomorphine (Apokyn), pramipexole (Mirapex), ropinirole (Requip) & rotigotine (Neupro) transdermal patch, to maintain consistent level of dopamine
Dopamine Agonist SE Orthostatic Hypotension, Hallucinations, sleppiness & drowsiness, avoid operating heavy machinery & driving, not for elderly
Sinemet combo Levodopa-carbidopa almost all pts are on this at some time, take before meals, LT use leads to dyskinesia
COMT's inactivate dopamine & prolong action of levodopa. entacapone (Comtan) used in combo w/levodopa, Stalevo is a combo of levodopa, carbidopa, and entacapone
MAO-B Inhibitors Entacapone (Comtan) & Selegiline (Deprenyl, Eldepryl) given w/levodopa early mild disease. New drug rasagiline mesylate (Azilect)
MAO-B Inhibitor SE Avoid foods, beverages, and drugs that contain tyramine including aged smoked or cured foods & sausage. Avoid red wine & beer
Dopamine Recepter Antagonist bromocriptine mesylate (Parlodel) used when other drugs are no longer effective
Antiviral Drug Amantadine (Symmetrel) give early in disease tx and with Sinemet
Cholinesterase Inhibitor Rivastigmine (Exelon) Pused for pts that have PD w/dementia.
Anticholinergic Drugs benztropine (cogentin) & procyclidine (Kemadrin) given for severe tremors & rigidity. NOT for older adults- causes confusion, urinary retention, constipation, dry mouth, & blurred vision
Created by: ginabeana
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