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VN140 Neuro Pharm
Question | Answer |
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ANTIMIGRAINE AGENTS | block nerve impulses at receptors of the sympathetic nervous system. It relieves pain by narrowing/constricting dialted cerebral arteries |
ANTIMIGRAINE AGENTS - adverse reaction | heart murmur, brief tachycardia, confusion, depression, dizziness, drowsiness, fixed miosis of the pupil of the eye, paresthesias in the toes, weakness, nausea and vomiting |
ANTIMIGRAINE AGENTS - drug interaction | the 5-HT agonists may not be used within 24 hrs of taking an ergotamine-containing preparation and may not be used at the same time with MAO inhibitor therapy (given for depression) |
ANTIMIGRAINE AGENTS - drugs | sumatriptan succinate (Imitrex) or DHE 45 or Migranal |
ANTIMIGRAINE AGENTS - drugs -Imitrex | do not give to pt with schemic heart disease due to constricted heart |
ANTIMIGRAINE AGENTS - drugs -Migranal | can be given to pregnant women. Does not have oxytoxic effect than other antimigraine drugs |
ANTIMIGRAINE AGENTS - Nursing interventions | histor of headaches, family history of vascular headaches or history of motion sickess as a child, series of headaches in clusters, hypertension, food allergy, HERBAL PRODUCTS or vitamins, NSAIDs |
ANTIMIGRAINE AGENTS - Family teaching | contact physician immediately if numbness on cold extremeties or pain in the legs occur. May produce stomach upset. Should lie die immediately in a quite, dark room. |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS | drugs to control seizures through depression or slowing of abnormal electrical discharges in the CNS |
seizures | sudden muscle contractions that happen without conscious control. |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS -4 classes | barbiturates, benzodiazepines, hydantoins, succinimides |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES | have long duration action, are the primary category of prescription anticonvulsants and are used for their sedative effect on the brain. Action occurs in the brainstem. |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES -uses | status epilepticus, prevent and control grand mal seizures. May treat seizures caused by tetanus, fevers or drugs |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES -drug | Phenobarbital |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES -adverse reaction | dizziness, drowsiness, hangover, headache, lethargy, pardoxical restlessness or excitement, unsteadiness, photosensitivity |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES -adverse reaction (overdosage) | exaggerated CNS depression, slow, shallow respiratory, miosis, tachycardia, arefelxia, shock or coma |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BARBITURATES -drug interraction | may be significant additive effects if used along with alcohol, antihistamines, benzodiazpines, methotrimeprazine, narcotics, and tranquilizers |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES | CNS depressants; supress electrical discharge in seizures |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES - uses | treat minor seizures, Lennox-Gestault syndrome (petit mal) |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES - adverse reaction | hypotension, shortness of breath, difficulty focusing or blurred vision, confusion |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES - adverse reaction (overdosage) | may produce marked drowsiness, weakness, impairement of stance and gait, confusion and coma |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES - drug interaction | alcohol, other sedatives and hypnotics, antidepressants, anticonvolsants and narcotics |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - BENZODIAZEPINES - drug | valium (drug of choice for status epilepticus) and klonopin (myoclonic seizure) |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS | work primarily on the motor cortex, where they stop the spread of seizure activity by increasing or decreasing NA+ ion movement across the motor cortex during the generation of nerve impulses |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS -uses | grand mal and psychomotor seizures, status epilepticus, migraines and trigeminal neuralgia |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS -adverse reaction | NYSTAGMUS (rhythmic movement of the eyes |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS - kids implications | give kids higher dosage due to higher metabolism |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS - nursing implications | ask doctor to monitor every 6 months for therapeutic effects; ORAL HYGIENE |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - HYDANTOINS - drug | dilantin (dosage 300 - 400 mg/day) |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - SUCCINIMIDES | elevation of the seizure threshold n the cortex and basal ganglia and reduced synpatic response to low-frequency repetitive stimulation; controls petit mal seizures |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - SUCCINIMIDES -drug | ZARONTIN |
ANTICONVULSANTS/ANTIEPILEPTIC DRUGS - SUCCINIMIDES-drug interaction | if used with other anticonvulsants, then can result in increased sex drive or increased frequency of grand mal seizures. It can also bone marrow depressing drug |
ANTIEMETIC-ANTIVERTIGO AGENTS | factors that may provoke nausea and vomiting: some drugs, metabolic disorders, radiation, motion, gastric irritation, vestibular neuritis, or increases in central trigger zone dopamine levels or vomiting center acetylcholine levels |
ANTIEMETIC-ANTIVERTIGO AGENTS | agents act to redirect stimulation by stopping or reducing stimulation of the vomiting center |
ANTIEMETIC-ANTIVERTIGO AGENTS-uses | prevent and treat motion sickness or the nausea and vomiting that occur with surgery, anesthesia, and cancer treatment. SHOULD BE GIVEN 30 TO 60 MINS prior to travel |
ANTIEMETIC-ANTIVERTIGO AGENTS-adverse reaction | drowsiness is most common and drug tolerance with long term therapy. It has anticholigernic effects |
ANTIEMETIC-ANTIVERTIGO AGENTS-nursing implicaiton | avoid alcohol and keep hydrated |
ANTIEMETIC-ANTIVERTIGO AGENTS-drugs | Compazine, Dramamine, Benadryl, antivert |
ANTIPARKINSONIAN AGENTS | also called paralysis agitans. Change in neurotransmitters produced in the brain; excessive acetylcholine, deficient dopamine. It blocks the uptake of acetylcholine and elevate the functional levels of dopamine in the motor regulator centers |
tardive dyskinesia | difficulty in performing voluntary movements |
ANTIPARKINSONIAN AGENTS-adverse reactions | may produce dysrhythmias. Anticholigernic agents may cause postural hypotension. Early signs of toxicity in pt include muscle twitching and blepharospasm (eyelid spasm) |
ANTIPARKINSONIAN AGENTS-drugs (anticholigernic) | Cogentin, Benadryl |
ANTIPARKINSONIAN AGENTS-drugs (Dopaminergic) | amantedine (Symmetrel) and carbidopa-levodopa (Sinemet) |
ANTIPARKINSONIAN AGENTS-adverse reactions | long term use may lead to akinesia(loss of movement), tardive dyskinesia and dystonia (impairment of muscle tone) |
ANTIPARKINSONIAN AGENTS-Pt teaching | clinical improvements may take up to 2 to 3 wks. Should be taken after meals to avoid stomach upset, should be taking vitamin prep with vit B. should avoid overexertion during hot weather |
PSYCHOTHERAPEUTIC AGENTS | antianxiety meds, antidepressants, antipsychotic, antimanic and sedation-hypnotic meds |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS | anxiety is common. It is problematic when it interferes with a person's abilit to perform activities of daily living |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS -action | produce a calming effect. BENZODIAZEPINES depress the CNS |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS -uses | relieve anxiety, tension and fear. May be used to manage alcohol withdrawal symptoms; used preoperatively; used to relieve muscle spasm |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS - herbal | chamomile, kava kava, st john's wort and valerian |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS -overdosage | may produce sleepiness, confusion, coma, dimished reflexes and hypotension |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS -drug interaction | may increase either agent's effect: alcohol, anesthetics, MAO inhibitors or CNS depressants. Caffeineted products and excessive cigarrette smoking can antagonize the anxiolytic effect of these drugs. |
PSYCHOTHERAPEUTIC AGENTS -ANTIANXIETY AGENTS -drugs | xanax, valium, ativan, serax, |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS | Tricyclics, MAOIs, SSRIs, Misc |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -TRICYCLIC ANTIDEPRESSANTS | believe to inhibit the reuptake of norepinephrine and or serotonin. To treat endogenous (chemical) depression; mild depression due to exogenous (outside) causes |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -TRICYCLIC ANTIDEPRESSANTS-nursing implicaiton | desired effect of the drug will usually occur within 1 to 4 wks after therapy is initiated. Usually stopped several days before pt has any surgery that requires anesthesia |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -MONOAMINE OXIDASE INHIBITORS (MAOI) | naturally occuring enzyme found in the mitochondria of cells; located in nerve endings, kidneys, liver and intestines; normally acts as catalyst to inactivate dopamine, norepinephrine, epinephrine, and seratonin. |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -MONOAMINE OXIDASE INHIBITORS (MAOI) | it blocks the inactivation of these bigenic amines, resulting in increased concentrations at neuronal synapses and antidepressant effects. |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -MONOAMINE OXIDASE INHIBITORS (MAOI) -nursing implication | avoid grapefruit. Sudden or severe hypertension if taken with certain foods or bev. Ie chees, yogurt, sour cream, raisin, banana, avocado, etc |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -SELECTIVE SERATONIN REUPTAKE INHIBITORS | act by inhibiting CNS neuronal uptake of serotonin, used short term for treatment of outpatients w diagnosis listed as a category of major depressive disorders in the DSM-IV |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -SELECTIVE SERATONIN REUPTAKE INHIBITORS | used for long term for dysthymic and minor depressive disorders |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -SELECTIVE SERATONIN REUPTAKE INHIBITORS -drug interactin | fluoxetine increases the half life of some drugs and may displace drugs bound to protein, such as warfarin and digitoxin or be displaced by them |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -SELECTIVE SERATONIN REUPTAKE INHIBITORS -drugs -Tetracyclic compounds | mirtazapine (Remeron) and trazodone (Desyrel) |
PSYCHOTHERAPEUTIC AGENTS -ANTIDEPRESSANTS -SELECTIVE SERATONIN REUPTAKE INHIBITORS -drugs -Unrelated | Welbutrin |
ANTIPSYCHOTIC DRUGS | all antipsychotic agents act by blocking the action of dopamine in the brain. Used in the treatment of severe mental illness. May be used in combination w major tranquilizers |
ANTIPSYCHOTIC DRUGS -PHENOTHIAZINES AND THIOXANTHENES | block dopamine at the postsynaptic receptor to increase the metabolism of dopamine, reduce sensory stimulation and produce a sedating effect. Act as intiemetic by inhibiting action in the chemoreceptor center |
ANTIPSYCHOTIC DRUGS -PHENOTHIAZINES AND THIOXANTHENES | reducing and relieving acute and chronic pschosis of schzophrenia, schizoaffective disorders, and involutional psychosis |
ANTIPSYCHOTIC DRUGS -NONPHENOTHIAZINES | mechanism of action for these products is often not precisely understood when used to treat psychotic patients |
ANTIPSYCHOTIC DRUGS -ANTIMANICS | exact mechanism of lithium's action is unknown; alters sodium transport at nerve endings and enhances uptake of seratonin and norepinephrine by the cells (inactivates neurotransmiters) |
ANTIPSYCHOTIC DRUGS -ANTIMANICS | mood stabilizing drug; used to treat pts with bipolar disorder who are in acute manic phase; prevents recurrent manic episodes |
ANTIPSYCHOTIC DRUGS -ANTIMANICS -drug interraction | use of lithium together with diuretics can lead to lithium toxicity |
ANTIPSYCHOTIC DRUGS -ANTIMANICS -nursing implication | make sure pt is hydrated, must be monitored on a regular basis. Blood should be drawn 12 hrs after does. The therapeutic serum lithium level is 1 to 1.5 mEq/L |
ANTIPSYCHOTIC DRUGS -SEDATIVE HYPNOTIC MEDICATIONS | used to relax pts and induce sleep before medical testing and surgical procedures; used to treat insomnia caused by mental and physical stres |
sedative agent | relaxes the pt and allows him or her to sleep |
hypnotic agent | produces sleep in the pt |