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CNS Drugs B&S

QuestionAnswer
Phenobarbitol (Luminol) Tx: Partial seizures,Generalized tonic-clonic seizures Adverse: Sedation, cognitive dysfunction Teratogenic: Preganacy category “D”
Phenytoin (Dilantin) Tx:All seizure except absence IV: status epilepticus Don’t give with food Adjust 4 hypoalbuminemia Gingival hypertrophy, ataxia, nystagmus, confusion, slurred speech, drowsiness, hypoglycemia, hirsutism, calcium/Vitamin D deficiencies
Diazepam (Valium) Lorazepam (Ativan) Adverse effects Respiratory depression, anterograde amnesia FLUMAZENIL (Romazicon) is the reversal agent used for over sedation with benzo’s.
Carbamazepine (Tegretol) Tx:Partial seizures Generalized tonic-clonic seizures Bipolar disorders *Bone marrow suppression Adverse:Dizziness, somnolence, ataxia, N/V, rash
Ethosuximide (Zarontin) Tx: Absence seizures only Nausea (GI effects), hiccups, drowsiness (CNS effects), headache, rash
Valproate (Depakote, Depakene) Partial generalized and, absence Tx:seizures Bipolar disorder Migraine headaches Nausea/GI upset, weight gain, alopecia, drowsiness, ataxia, tremor, thrombocytopenia, elevation of LFTs Hepatic failure resulting in death **Don't mix with carb drinks
Gabapentin (Neurontin) Tx:Monotherapy or adjunct for partial seizures Migraine headaches Neuropathic pain (most common use) Adverse effects Common: drowsiness, dizziness, ataxia, weight gain, nystagmus
Pregnancy Category D Barbiturates Phenytoin Carbamazepine Valproic acid
Carbamazepine Contraindicated in patients with bone marrow suppression, bleeding disorders
Phenytoin Contraindicated in sinus bradycardia, sinoatrial blocks, 2nd/3rd degree AV block, Stokes-Adams syndrome
Valproic acid Contraindicated in patients with liver disorders
Created by: prort
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